Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 3
RGS1 Antibody (PA5-86730) in IHC (P)
Immunohistochemical analysis of RGS1 in paraffin-embedded human colon carcinoma tissue showing cytoplasmic/nucleus staining and negative control (right). Sample was incubated with polyclonal RGS1 antibody (Product # PA5-86730) using a 1:50 dilution, and followed by goat anti-rabbit IgG-biotin and avidin-peroxidase secondary antibodies.
Product Details
PA5-86730
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, corresponding to amino acids 161-206 of Human RGS1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2803490
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
This gene encodes a member of the regulator of G-protein signaling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: B-cell activation protein BL34; Early response protein 1R20; epididymis secretory protein Li 87; immediate-early response 1, B-cell specific; Regulator of G-protein signaling 1; regulator of G-protein signalling 1; RGS1
Gene Aliases: 1R20; BL34; HEL-S-87; IER1; IR20; RGS1
UniProt ID: (Human) Q08116, (Mouse) Q9JL25, (Rat) P97844
Entrez Gene ID: (Human) 5996, (Mouse) 50778, (Rat) 54289
immune response
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
negative regulation of signal transduction
positive regulation of GTPase activity
leukotriene signaling pathway
termination of G-protein coupled receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support