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Invitrogen
RGS14 Polyclonal Antibody
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Product Details
PA5-87075
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein of human RGS14.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2803828
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
RGS14 is a member of the regulator of G-protein signaling family which contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. RGS14 attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. The resulting hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of RGS14 have been observed but have not been thoroughly characterized. Further, RGS14 acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism; plays a role in cell division; is required for the nerve growth factor (NGF)-mediated neurite outgrowth, and is involved in stress resistance. RGS14 protein may also be involved in visual memory processing capacity and hippocampal-based learning and memory.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: rap1/rap2 interacting protein; RAP1/RAP2-interacting protein; Regulator of G-protein signaling 14; regulator of G-protein signalling 14; RGS14; RGSE; RPIP1
Gene Aliases: RGS14; RPIP1
UniProt ID: (Human) O43566, (Mouse) P97492, (Rat) O08773
Entrez Gene ID: (Human) 10636, (Mouse) 51791, (Rat) 114705
nucleocytoplasmic transport
response to oxidative stress
cell cycle
spindle organization
chromosome segregation
mitotic nuclear division
signal transduction
G-protein coupled receptor signaling pathway
multicellular organism development
learning
long-term memory
regulation of G-protein coupled receptor protein signaling pathway
visual learning
negative regulation of signal transduction
zygote asymmetric cell division
negative regulation of synaptic plasticity
intracellular signal transduction
termination of G-protein coupled receptor signaling pathway
negative regulation of MAP kinase activity
positive regulation of GTPase activity
regulation of DNA-templated transcription in response to stress
platelet-derived growth factor receptor signaling pathway
positive regulation of neurogenesis
cell division
long-term synaptic potentiation
negative regulation of ERK1 and ERK2 cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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