Proteintech

RGS5 Polyclonal Antibody

RGS5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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RGS5 Antibody (11590-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using (Product # 11590-1-AP) (RGS5 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

11590-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 6 publications 6 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RGS5 Fusion Protein Ag2196 (1-181 aa encoded by BC030059)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The 42 kDa band recognized by this antibody is a RGS5-RGS5 dimer.

Immunogen sequence: MCKGLAALP HSCLERAKEI KIKLGILLQK PDSVGDLVIP YNEKPEKPAK TQKTSLDEAL QWRDSLDKLL QNNYGLASFK SFLKSEFSEE NLEFWIACED YKKIKSPAKM AEKAKQIYEE FIQTEAPKEV NIDHFTKDIT MKNLVEPSLS SFDMAQKRIH ALMEKDSLPR FVRSEFYQEL IK (1-181 aa encoded by BC030059)

Target Information

The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. The mRNA of the human gene is abundantly expressed in heart, lung, skeletal muscle, and small intestine, and at low levels in brain, placenta, liver, colon, and leukocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Resmetirom Ameliorates NASH-Model Mice by Suppressing STAT3 and NF-κB Signaling Pathways in an RGS5-Dependent Manner.

International journal of molecular sciences

Wang X,Wang L,Geng L,Tanaka N,Ye B

Sun Mar 19 00:00:00 UTC 2023

Single-cell RNA sequencing analysis revealed cellular and molecular immune profiles in lung squamous cell carcinoma.

Translational oncology

Hao B,Zhang Z,Lu Z,Xiong J,Fan T,Song C,He R,Zhang L,Pan S,Li D,Meng H,Lin W,Luo B,Yang J,Li N,Geng Q

Sun Jan 01 00:00:00 UTC 2023

Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Esophageal Squamous Cell Carcinoma.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Jia Y,Zhang B,Zhang C,Kwong DL,Chang Z,Li S,Wang Z,Han H,Li J,Zhong Y,Sui X,Fu L,Guan X,Qin Y

Wed Mar 01 00:00:00 UTC 2023

RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes.

Biology open

Enström A,Carlsson R,Özen I,Paul G

Sat Oct 15 00:00:00 UTC 2022

An integrated map of fibroblastic populations in human colon mucosa and cancer tissues.

Communications biology

Li S,Lu R,Shu L,Chen Y,Zhao J,Dai J,Huang Q,Li X,Meng W,Long F,Li Y,Fan C,Zhou Z,Mo X

Sat Dec 03 00:00:00 UTC 2022

A regulator of G protein signaling 5 marked subpopulation of vascular smooth muscle cells is lost during vascular disease.

PloS one

Gao YK,Guo RJ,Xu X,Huang XF,Song Y,Zhang DD,Chen N,Wang XW,Liang CX,Kong P,Han M

Tue May 03 00:00:00 UTC 2022

A regulator of G protein signaling 5 marked subpopulation of vascular smooth muscle cells is lost during vascular disease.

PloS one

Gao YK,Guo RJ,Xu X,Huang XF,Song Y,Zhang DD,Chen N,Wang XW,Liang CX,Kong P,Han M

Tue May 03 00:00:00 UTC 2022

HuR (Human Antigen R) Regulates the Contraction of Vascular Smooth Muscle and Maintains Blood Pressure.

Arteriosclerosis, thrombosis, and vascular biology

Liu S,Jiang X,Lu H,Xing M,Qiao Y,Zhang C,Zhang W

Wed Apr 01 00:00:00 UTC 2020

Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma.

Nature communications

Chen Z,Zhou L,Liu L,Hou Y,Xiong M,Yang Y,Hu J,Chen K

Thu Oct 08 00:00:00 UTC 2020

Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds.

Nature communications

Guerrero-Juarez CF,Dedhia PH,Jin S,Ruiz-Vega R,Ma D,Liu Y,Yamaga K,Shestova O,Gay DL,Yang Z,Kessenbrock K,Nie Q,Pear WS,Cotsarelis G,Plikus MV

Fri Feb 08 00:00:00 UTC 2019

Beta-Arrestin1 Prevents Preeclampsia by Downregulation of Mechanosensitive AT1-B2 Receptor Heteromers.

Cell

Quitterer U,Fu X,Pohl A,Bayoumy KM,Langer A,AbdAlla S

Thu Jan 10 00:00:00 UTC 2019

Beta-Arrestin1 Prevents Preeclampsia by Downregulation of Mechanosensitive AT1-B2 Receptor Heteromers.

Cell

Quitterer U,Fu X,Pohl A,Bayoumy KM,Langer A,AbdAlla S

Thu Jan 10 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: regulator of G protein signaling 5; Regulator of G-protein signaling 5; RGS-5; RGS5; RP11-430G6.2

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Gene Aliases: 1110070A02Rik; MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129; RGS5

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UniProt ID: (Human) O15539, (Mouse) O08850, (Rat) P49800

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Entrez Gene ID: (Human) 8490, (Mouse) 19737, (Rat) 54294

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Function(s)

GTPase activator activity

Process(es)

signal transduction G-protein coupled receptor signaling pathway negative regulation of signal transduction termination of G-protein coupled receptor signaling pathway positive regulation of GTPase activity negative regulation of G-protein coupled receptor protein signaling pathway regulation of G-protein coupled receptor protein signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RGS5 Polyclonal Antibody

RGS5 Antibody (11590-1-AP) in IHC (P)

Product Details

11590-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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