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Proteintech
RGS9 Polyclonal Antibody
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Product Details
17970-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RGS9 Fusion Protein Ag11976 (273-622 aa encoded by BC022504)
Conjugate
Form
Liquid
Concentration
0.37 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody got about 58kD in the mouse eye and 70kD in the mouse brain in western blotting, both in line with their expected masses. Defects in RGS9 are a cause of prolonged electroretinal response suppression (PERRS).
Immunogen sequence: SGENLGFWE ACEDLKYGDQ SKVKEKAEEI YKLFLAPGAR RWINIDGKTM DITVKGLKHP HRYVLDAAQT HIYMLMKKDS YARYLKSPIY KDMLAKAIEP QETTKKSSTL PFMRRHLRSS PSPVILRQLE EEAKAREAAN TVDITQPGQH MAPSPHLTVY TGTCMPPSPS SPFSSSCRSP RKPFASPSRF IRRPSTTICP SPIRVALESS SGLEQKGECS GSMAPRGPSV TESSEASLDT SWPRSRPRAP PKARMALSFS RFLRRGCLAS PVFARLSPKC PAVSHGRVQP LGDVGQQLPR LKSKRVANFF QIKMDVPTGS GTCLMDSEDA GTGESGDRAT EKEVICPWES L (273-622 aa encoded by BC022504)
Target Information
The cascade of biochemical reactions within the vision system is complex and contains numerous steps taking place in nanoseconds. RGS is a family of GTPase accelerating proteins (GAPs). RGS9 is a member of this family and is the predominant source of GAP activity in rod outer segments. RGS9-1, found predominately in vertebrate cone and rod photoreceptors, is a useful model for understanding how rapid recovery kinetics of the light responses in retinal photoreceptors take place.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MGC111763; MGC26458; Regulator of G-protein signaling 9; regulator of G-protein signalling 9; RGS9; ROS GAP
Gene Aliases: PERRS; RGS9; RGS9-1; Rgs9-2; RGS9L
UniProt ID: (Human) O75916, (Rat) P49805, (Mouse) O54828
Entrez Gene ID: (Human) 8787, (Rat) 29481, (Mouse) 19739
protein folding
dopamine receptor signaling pathway
nervous system development
visual perception
regulation of G-protein coupled receptor protein signaling pathway
negative regulation of signal transduction
intracellular signal transduction
positive regulation of GTPase activity
response to estrogen
termination of G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway
response to stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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