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Proteintech
RHBDD1 Polyclonal Antibody
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Product Details
20869-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RHBDD1 Fusion Protein Ag14932 (13-106 aa encoded by BC027900)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SSSVGYPGR QYYFNSSGSS GYQDYYPHGR PDHYEEAPRN YDTYTAGLSE EEQLERALQA SLWDRGNTRN SPPPYGFHLS PEEMRRQRLH RFDSQ (13-106 aa encoded by B C027900)
Target Information
The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD1 is highly expressed in the testis and is involved in the cleavage of BIK, a proapoptotic member of the Bcl-2 family. Overexpression or suppression by RNAi of RHBDD1 in 293 cells will reduce or enhance BIK-mediated apoptosis, respectively, demonstrating that RHBDD1 modulates BIK-mediated apoptotic activity. In GC-1 cells, a spermatogonia cell line that can differentiate into spermatids within the seminiferous tubules, suppression of RHBDD1 expression by RNAi caused the cells to lose the ability to survive and differentiate in mouse seminiferous tubules, suggesting that RHBDD1 may be associated with mammalian spermatogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: mRHBDD1; Rhomboid domain-containing protein 1; Rhomboid-like protein 4; Rhomboid-related protein 4; rRHBDD1; RRP4
Gene Aliases: 4930418P06Rik; HSD-50; HSD50; mRHBDD1; MSD-50; MSD50; RGD1306477; RHBDD1; RHBDL4; rRHBDD1; RRP4
UniProt ID: (Human) Q8TEB9, (Rat) Q4V8F3, (Mouse) Q8BHC7
Entrez Gene ID: (Human) 84236, (Rat) 316557, (Mouse) 76867
apoptotic process
positive regulation of protein processing
ER-associated ubiquitin-dependent protein catabolic process
membrane protein intracellular domain proteolysis
membrane protein proteolysis
cellular response to unfolded protein
cellular response to UV
negative regulation of apoptotic process
post-translational protein modification
positive regulation of protein catabolic process
spermatid differentiation
positive regulation of secretion
regulation of male germ cell proliferation
proteolysis
spermatogenesis
cell differentiation
ERAD pathway
membrane protein proteolysis involved in retrograde protein transport, ER to cytosol
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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