Proteintech

RHBDL2 Polyclonal Antibody

View all (7) RHBDL2 antibodies

Questions & Answers

Questions & Answers

Antibody Testing Data (1)

RHBDL2 Antibody in Western Blot (WB)

RHBDL2 Antibody in Western Blot (WB)

FIGURE: 1 / 1

RHBDL2 Antibody (12467-1-AP) in WB

HeLa cells were subjected to SDS PAGE followed by western blot with 12467-1-AP (RHBDL2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

RHBDL2 Antibody in Western Blot (WB)

Product Image Gallery

RHBDL2 Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 12467-1-AP (RHBDL2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

Product Details

12467-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

-

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RHBDL2 Fusion Protein Ag3142 (1-132 aa encoded by BC013103)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAAVHDLEM ESMNLNMGRE MKEELEEEEK MREDGGGKDR AKSKKVHRIV SKWMLPEKSR GTYLERANCF PPPVFIISIS LAELAVFIYY AVWKPQKQWI TLDTGILESP FIYSPEKREE AWRFISYMLV HAG (1-132 aa encoded by BC013103)

Target Information

RHBDL2 is a member of the rhomboid family of integral membrane proteins. This family contains proteins that are related to Drosophila rhomboid protein. Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases. RHBDL2 is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

RHBDL2 promotes the proliferation, migration, and invasion of pancreatic cancer by stabilizing the N1ICD via the OTUD7B and activating the Notch signaling pathway.

Cell death & disease

Chen S,Cai K,Zheng D,Liu Y,Li L,He Z,Sun C,Yu C

Wed Nov 09 00:00:00 UTC 2022

RHBDL2 promotes the proliferation, migration, and invasion of pancreatic cancer by stabilizing the N1ICD via the OTUD7B and activating the Notch signaling pathway.

Cell death & disease

Chen S,Cai K,Zheng D,Liu Y,Li L,He Z,Sun C,Yu C

Wed Nov 09 00:00:00 UTC 2022

RHBDL2 promotes the proliferation, migration, and invasion of pancreatic cancer by stabilizing the N1ICD via the OTUD7B and activating the Notch signaling pathway.

Cell death & disease

Chen S,Cai K,Zheng D,Liu Y,Li L,He Z,Sun C,Yu C

Wed Nov 09 00:00:00 UTC 2022

RHBDL2 promotes the proliferation, migration, and invasion of pancreatic cancer by stabilizing the N1ICD via the OTUD7B and activating the Notch signaling pathway.

Cell death & disease

Chen S,Cai K,Zheng D,Liu Y,Li L,He Z,Sun C,Yu C

Wed Nov 09 00:00:00 UTC 2022

RHBDL2 promotes the proliferation, migration, and invasion of pancreatic cancer by stabilizing the N1ICD via the OTUD7B and activating the Notch signaling pathway.

Cell death & disease

Chen S,Cai K,Zheng D,Liu Y,Li L,He Z,Sun C,Yu C

Wed Nov 09 00:00:00 UTC 2022

RHBDL2 promotes the proliferation, migration, and invasion of pancreatic cancer by stabilizing the N1ICD via the OTUD7B and activating the Notch signaling pathway.

Cell death & disease

Chen S,Cai K,Zheng D,Liu Y,Li L,He Z,Sun C,Yu C

Wed Nov 09 00:00:00 UTC 2022

Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation.

Molecular cell

Grieve AG,Yeh YC,Chang YF,Huang HY,Zarcone L,Breuning J,Johnson N,Stříšovský K,Brown MH,Parekh AB,Freeman M

Thu Dec 02 00:00:00 UTC 2021

Membrane Protein Dimerization in Cell-Derived Lipid Membranes Measured by FRET with MC Simulations.

Biophysical journal

Škerle J,Humpolíčková J,Johnson N,Rampírová P,Poláchová E,Fliegl M,Dohnálek J,Suchánková A,Jakubec D,Strisovsky K

Tue Apr 21 00:00:00 UTC 2020

Rhomboid-Like-2 Intramembrane Protease Mediates Metalloprotease-Independent Regulation of Cadherins.

International journal of molecular sciences

Battistini C,Rehman M,Avolio M,Arduin A,Valdembri D,Serini G,Tamagnone L

Wed Nov 27 00:00:00 UTC 2019

Rhomboid-Like-2 Intramembrane Protease Mediates Metalloprotease-Independent Regulation of Cadherins.

International journal of molecular sciences

Battistini C,Rehman M,Avolio M,Arduin A,Valdembri D,Serini G,Tamagnone L

Wed Nov 27 00:00:00 UTC 2019

Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis.

Scientific reports

Johnson N,Březinová J,Stephens E,Burbridge E,Freeman M,Adrain C,Strisovsky K

Fri Aug 04 00:00:00 UTC 2017

Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis.

Scientific reports

Johnson N,Březinová J,Stephens E,Burbridge E,Freeman M,Adrain C,Strisovsky K

Fri Aug 04 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: rhomboid (veinlet, Drosophila)-like 2; rhomboid protease 2; rhomboid, veinlet-like 2; Rhomboid-like protein 2; Rhomboid-related protein 2; RRP2

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Gene Aliases: RHBDL2; RRP2

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UniProt ID: (Human) Q9NX52

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Entrez Gene ID: (Human) 54933

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serine-type endopeptidase activity

protein processing

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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