Proteintech

RIM1 Polyclonal Antibody

RIM1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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RIM1 Antibody (24576-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse brain tissue slide using 24576-1-AP (RIM1 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

RIM1 Antibody in Immunoprecipitation (IP)

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Product Details

24576-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RIM1 Fusion Protein Ag20161 (923-1039 aa encoded by BC152435)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.43 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KSTTLTVPE QQRTTHHRSR SVSPHRGNDQ GKPRSRLPNV PLQRSLDEIH PTRRSRSPTR HHDASRSPVD HRTRDVDSQY LSEQDSELLM LPRAKRGRSA ECLHTTR (923-1039 aa encoded by BC152435)

Target Information

Rims1 is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. Rims1 also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations in the Rims1 gene have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Further, Rims1 may act as scaffold protein that regulates neurotransmitter release at the active zone. Rims1 may also be essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Rims1 also plays a role in dendrite formation by melanocytes. Multiple transcript variants encoding different isoforms have been described for this Rims1. Diseases associated with RIMS1 include Cone-Rod Dystrophy 7 and Retinitis Pigmentosa.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.

iScience

Hsu YH,Pintacuda G,Liu R,Nacu E,Kim A,Tsafou K,Petrossian N,Crotty W,Suh JM,Riseman J,Martin JM,Biagini JC,Mena D,Ching JKT,Malolepsza E,Li T,Singh T,Ge T,Egri SB,Tanenbaum B,Stanclift CR,Apffel AM,Carr SA,Schenone M,Jaffe J,Fornelos N,Huang H,Eggan KC,Lage K

Fri May 19 00:00:00 UTC 2023

Effects of exercise-induced fatigue on the morphology of asymmetric synapse and synaptic protein levels in rat striatum.

Neurochemistry international

Wang Z,Hou L,Wang D

Tue Oct 01 00:00:00 UTC 2019

Differential Regulation of Evoked and Spontaneous Release by Presynaptic NMDA Receptors.

Neuron

Abrahamsson T,Chou CYC,Li SY,Mancino A,Costa RP,Brock JA,Nuro E,Buchanan KA,Elgar D,Blackman AV,Tudor-Jones A,Oyrer J,Farmer WT,Murai KK,Sjöström PJ

Wed Nov 15 00:00:00 UTC 2017

Abnormal Expression of FBXL20 in Refractory Epilepsy Patients and a Pilocarpine-Induced Rat Model.

Neurochemical research

Fu P,Wen Y,Xiong Y,Zhang Y,Zhang H,Xie Y,Shi Q

Tue Nov 01 00:00:00 UTC 2016

Abnormal Expression of FBXL20 in Refractory Epilepsy Patients and a Pilocarpine-Induced Rat Model.

Neurochemical research

Fu P,Wen Y,Xiong Y,Zhang Y,Zhang H,Xie Y,Shi Q

Tue Nov 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: Rab-3-interacting molecule 1; Rab-3-interacting protein 1; Rab-3-interacting protein 2; Rab3 effector; Rab3 interacting protein 1; rab3-interacting molecule 1; rab3-interacting protein 1; RAB3-interacting protein 2; regulating synaptic membrane exocytosis 1 beta; Regulating synaptic membrane exocytosis protein 1; RIM 1; Rim1b protein; synaptic exocytosis regulator 1

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Gene Aliases: C030033M19Rik; CORD7; KIAA0340; mKIAA0340; Nbla00761; Rab3ip1; RAB3IP2; RIM; RIM1; RIM1a; RIM1alpha; RIMS1; Serg1

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UniProt ID: (Human) Q86UR5, (Mouse) Q99NE5, (Rat) Q9JIR4

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Entrez Gene ID: (Human) 22999, (Mouse) 116837, (Rat) 84556

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Function(s)

protein binding SH3 domain binding Rab GTPase binding GTPase regulator activity poly(A) RNA binding metal ion binding protein kinase binding ion channel binding

Process(es)

protein complex assembly transport neurotransmitter transport intracellular protein transport exocytosis positive regulation of gene expression positive regulation of synaptic vesicle priming regulation of membrane potential regulation of long-term neuronal synaptic plasticity calcium ion-regulated exocytosis of neurotransmitter long-term synaptic potentiation spontaneous neurotransmitter secretion positive regulation of inhibitory postsynaptic potential positive regulation of dendrite extension regulation of synaptic vesicle exocytosis positive regulation of excitatory postsynaptic potential positive regulation of synaptic vesicle fusion to presynaptic membrane neurotransmitter secretion visual perception glutamate secretion synaptic vesicle exocytosis calcium ion regulated exocytosis regulated exocytosis secretion regulation of neurotransmitter secretion regulation of catalytic activity response to stimulus membrane fusion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RIM1 Polyclonal Antibody

RIM1 Antibody (24576-1-AP) in IHC (P)

Product Details

24576-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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