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Product Details
OSR00337W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide to n-terminal region of human Rab3-interacting molecule 1 (RIMS1, RIM1) conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: RIM1.
Target Information
Rims1 is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. Rims1 also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations in the Rims1 gene have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Further, Rims1 may act as scaffold protein that regulates neurotransmitter release at the active zone. Rims1 may also be essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Rims1 also plays a role in dendrite formation by melanocytes. Multiple transcript variants encoding different isoforms have been described for this Rims1. Diseases associated with RIMS1 include Cone-Rod Dystrophy 7 and Retinitis Pigmentosa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Rab-3-interacting molecule 1; Rab-3-interacting protein 2; rab3-interacting molecule 1; RAB3-interacting protein 2; Regulating synaptic membrane exocytosis protein 1; RIM 1
Gene Aliases: CORD7; KIAA0340; Nbla00761; RAB3IP2; RIM; RIM1; RIMS1
UniProt ID: (Human) Q86UR5
Entrez Gene ID: (Human) 22999
protein complex assembly
intracellular protein transport
neurotransmitter secretion
visual perception
positive regulation of gene expression
glutamate secretion
synaptic vesicle exocytosis
calcium ion regulated exocytosis
regulated exocytosis
secretion
regulation of neurotransmitter secretion
regulation of catalytic activity
response to stimulus
long-term synaptic potentiation
membrane fusion
positive regulation of inhibitory postsynaptic potential
positive regulation of dendrite extension
positive regulation of excitatory postsynaptic potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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