Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
RIM1 Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 1
RIM1 Antibody (PA5-117424) in WB
Western blot analysis of RIM1 in Various tissue extracts (50 µg). Samples were separated with 5% SDS-PAGE and incubated in RIM1 polyclonal antibody (Product # PA5-117424) using a dilution of 1:500, followed by HRP-conjugated anti-rabbit IgG. Detection was performed with Trident ECL plus-Enhanced.
Product Details
PA5-117424
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of mouse RIM1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
4.11 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2902054
Product Specific Information
Centrifuge briefly prior to opening.
Target Information
Rims1 is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. Rims1 also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations in the Rims1 gene have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Further, Rims1 may act as scaffold protein that regulates neurotransmitter release at the active zone. Rims1 may also be essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Rims1 also plays a role in dendrite formation by melanocytes. Multiple transcript variants encoding different isoforms have been described for this Rims1. Diseases associated with RIMS1 include Cone-Rod Dystrophy 7 and Retinitis Pigmentosa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Rab-3-interacting molecule 1; Rab-3-interacting protein 1; Rab3 effector; Rab3 interacting protein 1; rab3-interacting molecule 1; rab3-interacting protein 1; regulating synaptic membrane exocytosis 1 beta; Regulating synaptic membrane exocytosis protein 1; RIM 1; Rim1b protein; synaptic exocytosis regulator 1
Gene Aliases: C030033M19Rik; Kiaa0340; mKIAA0340; Rab3ip1; Rim; RIM1; RIM1a; RIM1alpha; Rims1; Serg1
UniProt ID: (Mouse) Q99NE5, (Rat) Q9JIR4
Entrez Gene ID: (Mouse) 116837, (Rat) 84556
protein complex assembly
transport
neurotransmitter transport
intracellular protein transport
exocytosis
positive regulation of gene expression
positive regulation of synaptic vesicle priming
regulation of membrane potential
regulation of long-term neuronal synaptic plasticity
calcium ion-regulated exocytosis of neurotransmitter
long-term synaptic potentiation
spontaneous neurotransmitter secretion
positive regulation of inhibitory postsynaptic potential
positive regulation of dendrite extension
regulation of synaptic vesicle exocytosis
positive regulation of excitatory postsynaptic potential
positive regulation of synaptic vesicle fusion to presynaptic membrane
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support