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Immunogen sequence: MNGLATSLG KGQESAIGGS SAIGEYIRPL PQPGDRPEPL SAKPTFLSRS GSARCRSESD MENERNSNTS KQRYSGKVHL CVARYSYNPF DGPNENPEAE LPLTAGKYLY VYGDMDEDGF YEGELLDGQR GLVPSNFVDF VQDNESRLAS TLGNEQDQNF INHSGIGLEG EHILDLHSPT HIDAGITDNS AGTLDVNIDD IGEDIVPYPR KITLIKQLAK SVIVGWEPPA VPPGWGTVSS YNVLVDKETR MNLTLGSRTK ALIEKLNMAA CTYRISVQCV TSRGSSDELQ CTLLVGKDVV VAPSHLRVDN ITQISAQLSW LPTNSNYSHV IFLNEEEFDI VKAARYKYQF F (1-350 aa encoded by BC007632)
The presynaptic active zone mediates synaptic vesicle exocytosis at a synapse. RIM proteins are active zone scaffolding molecules that--among others--mediate vesicle priming and directly or indirectly interact with most other essential presynaptic proteins. RIMBP2 encodes RIMS-binding protein 2 belonging to RIMBP family. RIMBP2 is supposed to be localized at cell membrane especially synaptic plasma membrane. By interacting with RIMS1, RIMS2, CACNA1D and CACNA1B via the SH3 domains, RIMBP2 mediates synaptic transmission as bifunctional linker.
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Protein Aliases: protein phosphatase 1, regulatory subunit 133; RIM binding protein 2; RIM-BP2; RIMS-binding protein 2
Gene Aliases: A930033C01Rik; KIAA0318; mKIAA0318; PPP1R133; RBP2; RIM-BP2; RIMBP2
UniProt ID: (Human) O15034, (Mouse) Q80U40
Entrez Gene ID: (Human) 23504, (Rat) 266780, (Mouse) 231760
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