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Product Details
H00009699-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RIMS2 (NP_055492.2, 1 a.a. approximately 1163 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MQFETLRQVC NSVLSHFHGV FSSPPNILQN ELFGQTLNNA RKRSPSVSRD QNRRYDQREE REEYSQYATS DTAMPRSPSD YADRRFQHEP QFYEDSDHLS YRDSNRRSHR HSKEYIVDDE DVESRDEYER QRREEEYQSR YRSDPNLARY PVKPQPYEEQ MRIHAEVSRA RHERRHSDVS LANADLEDSR ISMLRMDRPS RQRSISERRA AMENQRSYSM ERTREAQGPS SYAQRTTNHS PPTPRRSPLP IDRPDLRRTD SLRKQHHLDP SSAVRKTKRE KMETMLRNDS LSSDRSESVR PPPPKPHKSK KGGKMRQISL SSSEEELAST PEYTSCDDVE IESESVSEKG DMDYNWLDHT SWHSSEASPM SLHPVTWQPS KDGDRLIGRI LLNKRLKDGS VPRDSGAMLG LKVVGGKMTE SGRLCAFITK VKKGSLADTV GHLRPGDEVL EWNGRLLQGA TFEEVYNIIL ESKPEPQVEL VVSRPIGDIP RIPDSTHAQL ESSSSSFESQ KMDRPSISVT SPMSPGMLRD VPQFLSGQLS IKLWFDKVGH QLIVTILGAK DLPSREDGRP RNPYVKIYFL PDRSDKNKRR TKTVKKTLEP KWNQTFIYSP VHRREFRERM LEITLWDQAR VREEESEFLG EILIELETAL LDDEPHWYKL QTHDVSSLPL PHPSPYMPRR QLHGESPTRR LQRSKRISDS EVSDYDCDDG IGVVSDYRHD GRDLQSSTLS VPEQVMSSNH CSPSGSPHRV DVIGRTRSWS PSVPPPQSRN VEQGLRGTRT MTGHYNTISR MDRHRVMDDH YSPDRDSHFL TLPRSRYSQT IDHHHRDGRD CEAADRQPYH RSRSTEQRPL LERTTTRSRS TERPDTNLMR SMPSLMTGRS APPSPALSRS HPRTGSVQTS PSSTPVAGRR GRQLPQLPPK GTLDRKAGGK KLRSTVQRST ETGLAVEMRN WMTRQASRES TDGSMNSYSS EGNLIFPGVR LASDSQFSDF LDGLGPAQLV GRQTLATPAM GDIQVGMMDK KGQLEVEIIR ARGLVVKPGS KTLPAPYVKV YLLDNGVCIA KKKTKVARKT LEPLYQQLLS FEESPQGKVL QIIVWGDYGR MDHKSFMGVA QILLDELELS NMVIGWFKLF PPSSLVDPTL APLTRRASQS SLESSTGPSY SRS
Target Information
Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: non-small cell lung cancer RimL3a protein; non-small cell lung cancer RimL3c protein; nuclear protein; Rab-3-interacting molecule 2; Rab-3-interacting protein 3; RAB3 interacting protein 3; rab3-interacting molecule 2; Rab3-interacting protein; Regulating synaptic membrane exocytosis protein 2; RIM 2; RIM2 (CT)
Gene Aliases: KIAA0751; OBOE; RAB3IP3; RIM2; RIMS2
UniProt ID: (Human) Q9UQ26
Entrez Gene ID: (Human) 9699
intracellular protein transport
positive regulation of gene expression
calcium ion regulated exocytosis
regulation of exocytosis
cAMP-mediated signaling
insulin secretion
regulation of membrane potential
calcium ion-regulated exocytosis of neurotransmitter
spontaneous neurotransmitter secretion
positive regulation of inhibitory postsynaptic potential
positive regulation of dendrite extension
positive regulation of excitatory postsynaptic potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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