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Proteintech
RIMS3 Polyclonal Antibody
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Product Details
15088-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RIMS3 Fusion Protein Ag7171 (1-308 aa encoded by BC003103)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MFNGEPGPA SSGASRNVVR SSSISGEICG SQQAGGGAGT TTAKKRRSSL GAKMVAIVGL TQWSKSTLQL PQPEGATKKL RSNIRRSTET GIAVEMRSRV TRQGSRESTD GSTNSNSSDG TFIFPTTRLG AESQFSDFLD GLGPAQIVGR QTLATPPMGD VHIAIMDRSG QLEVEVIEAR GLTPKPGSKS LPATYIKVYL LENGACLAKK KTKMTKKTCD PLYQQALLFD EGPQGKVLQV IVWGDYGRMD HKCFMGMAQI MLDELDLSAA VTGWYKLFPT SSVADSTLGS LTRRLSQSSL ESATSPSCS (1-308 aa encoded by BC003103 )
Target Information
Rab3-interacting molecules (RIMs) are synaptic proteins are synaptic proteins necessary for neural transmission and plasticity. While both Rim1 and Rim 2 are thought to be effector proteins for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner, less is known of Rim3. Expression of Rim3 in PC12 cells induced a significant increase in calcium-triggered exocytosis, with no appreciable change in the baseline release, suggesting that it plays a role in the regulation of exocytosis. Rim3 protein localizes primarily to neuronal dendrites and the postsynaptic densities, as opposed to Rim1 which is found in presynapse locations, indicating that Rim3 may contribute to synapse transmission and plasticity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Nim3; Rab-3 interacting molecule 3; Rab-3-interacting molecule 3; Regulating synaptic membrane exocytosis protein 3; RIM 3; RIM3 gamma; RP4-739H11.2
Gene Aliases: A730060M23Rik; KIAA0237; mKIAA0237; Nim2; NIM3; RIM3; RIMS3
UniProt ID: (Human) Q9UJD0, (Mouse) Q80U57, (Rat) Q9JIR3
Entrez Gene ID: (Human) 9783, (Mouse) 242662, (Rat) 65025
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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