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Proteintech
RIN1 Polyclonal Antibody
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Product Details
16388-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RIN1 Fusion Protein Ag9451 (434-783 aa encoded by BC014417)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KSLHCSVLK PLRPILAARL RRRLAADGSL GRLAEGLRLA RAQGPGAFGS HLSLPSPVEL EQVRQKLLQL LRTYSPSAQV KRLLQACKLL YMALRTQEGE GAGADEFLPL LSLVLAHCDL PELLLEAEYM SELLEPSLLT GEGGYYLTSL SASLALLSGL GQAHTLPLSP VQELRRSLSL WEQRRLPATH CFQHLLRVAY QDPSSGCTSK TLAVPPEASI ATLNQLCATK FRVTQPNTFG LFLYKEQGYH RLPPGALAHR LPTTGYLVYR RAEWPETQGA VTEEEGSGQS EARSRGEEQG CQGDGDAGVK ASPRDIREQS ETTAEGGQGQ AQEGPAQPGE PEAEGSRAAE E (434-783 aa encoded by BC014417)
Target Information
Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64% amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100% conserved between the murine and human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Ras and Rab interactor 1; ras inhibitor; ras inhibitor 1; Ras inhibitor JC99; ras inhibitor RIN1; Ras interaction/interference protein 1; RIBA; RIT2; ROC2
Gene Aliases: RIN1
UniProt ID: (Human) Q13671, (Rat) P97680, (Mouse) Q921Q7
Entrez Gene ID: (Human) 9610, (Rat) 207119, (Mouse) 225870
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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