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Peptide sequence: RTDVNLENGL EPAETHSMVR HKDGGYSEEE DVKTCARDSG YDSLSNRLSI
Sequence homology: Cow: 80%; Dog: 80%; Horse: 80%; Human: 100%; Mouse: 83%; Pig: 80%; Rat: 83%
The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: RAB5 interacting protein 2; Ras and Rab interactor 2; RAS association (RalGDS/AF-6) domain containing protein JC265; RAS association domain family 4; RAS inhibitor JC265; RAS interaction/interference protein 2
Gene Aliases: MACS; RASSF4; RIN2
UniProt ID: (Human) Q8WYP3
Entrez Gene ID: (Human) 54453
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