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Abnova
RKHD2 Polyclonal Antibody, MaxPab™
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Product Details
H00051320-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RKHD2 (AAI48856.1, 1 a.a. approximately 464 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MMAAMLSHAY GPGGCGAAAA ALNGEQAALL RRKSVNTTEC VPVPSSEHVA EIVGRQGCKI KALRAKTNTY IKTPVRGEEP IFVVTGRKED VAMAKREILS AAEHFSMIRA SRNKNGPALG GLSCSPNLPG QTTVQVRVPY RVVGLVVGPK GATIKRIQQQ THTYIVTPSR DKEPVFEVTG MPENVDRARE EIEMHIAMRT GNYIELNEEN DFHYNGTDVS FEGGTLGSAW LSSNPVPPSR ARMISNYRND SSSSLGSGST DSYFGSNRLA DFSPTSPFST GNFWFGDTLP SVGSEDLAVD SPAFDSLPTS AQTIWTPFEP VNPLSGFGSD PSGNMKTQRR GSQPSTPRLS PTFPESIEHP LARRVRSDPP STGNHVGLPI YIPAFSNGTN SYSSSNGGST SSSPPESRRK HDCVICFENE VIAALVPCGH NLFCMECANK ICEKRTPSCP VCQTAVTQAI QIHS
Target Information
Rkhd2, also known as MEX3C is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd2, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. It has been suggested that genetic variations in Rkhd2 may be associated with susceptibility to essential hypertension type 8. Rkhd3 and Rkhd4, but not Rkhd2, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MEX3C variant 1; MEX3C variant 2; ring finger and KH domain containing 2; RING finger and KH domain-containing protein 2; RING finger protein 194; RING-type E3 ubiquitin transferase MEX3C; RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein MEX3C
Gene Aliases: BM-013; MEX-3C; MEX3C; RKHD2; RNF194
UniProt ID: (Human) Q5U5Q3
Entrez Gene ID: (Human) 51320
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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