Proteintech

RLBP1 Polyclonal Antibody

RLBP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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RLBP1 Antibody (15356-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human eye using 15356-1-AP (RLBP1 antibody) at dilution of 1:50 (under 40x lens).

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Product Details

15356-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 10 publications 10 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RLBP1 Fusion Protein Ag7602 (1-317 aa encoded by BC004199)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSEGVGTFR MVPEEEQELR AQLEQLTTKD HGPVFGPCSQ LPRHTLQKAK DELNEREETR EEAVRELQEM VQAQAASGEE LAVAVAERVQ EKDSGFFLRF IRARKFNVGR AYELLRGYVN FRLQYPELFD SLSPEAVRCT IEAGYPGVLS SRDKYGRVVM LFNIENWQSQ EITFDEILQA YCFILEKLLE NEETQINGFC IIENFKGFTM QQAASLRTSD LRKMVDMLQD SFPARFKAIH FIHQPWYFTT TYNVVKPFLK SKLLERVFVH GDDLSGFYQE IDENILPSDF GGTLPKYDGK AVAEQLFGPQ AQAENTAF (1-317 aa encoded by BC004199)

Target Information

Cellular retinaldehyde-binding protein (CRALBP) plays an important role in the regeneration of 11-cis-retinal for use in rod visual pigments such as opsin and rhodopsin. Once 11-cis-retinal is photoisomerized in the rod outer segment, it is converted to all-trans-retinal and further modified into all-trans-retinol. All-trans-retinol then diffuses into the retinal pigment epithelium (RPE) to be converted back to 11-cis-retinol and further oxidized into 11-cis-retinal (both by CRALBP). Genetic mutations involving CRALBP's lack of function have been linked to visual disease such as bothnia dystrophy, retinitis punctata albescens, retina pigmentosa, and Newfoundland rod-cone dystrophy. The presence of CRALBP serves as a marker for RPE and Muller glial cells of the retina.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CD40 Upregulation in the Retina of Patients With Diabetic Retinopathy: Association With TRAF2/TRAF6 Upregulation and Inflammatory Molecule Expression.

Investigative ophthalmology & visual science

Vos S,Aaron R,Weng M,Daw J,Rodriguez-Rivera E,Subauste CS

Thu Jun 01 00:00:00 UTC 2023

Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration.

iScience

Tian H,Chen Z,Zhu X,Ou Q,Wang Z,Wu B,Xu JY,Jin C,Gao F,Wang J,Zhang J,Zhang J,Lu L,Xu GT

Fri Oct 21 00:00:00 UTC 2022

Morphological, biochemical, and transcriptomic characterization of iPSC-derived human RPE cells from normal and Smith-Lemli-Opitz syndrome patients.

Molecular vision

Farkas MH,Skelton LA,Ramachandra-Rao S,Au E,Fliesler SJ

Thu Dec 22 00:00:00 UTC 2022

Morphological, biochemical, and transcriptomic characterization of iPSC-derived human RPE cells from normal and Smith-Lemli-Opitz syndrome patients.

Molecular vision

Farkas MH,Skelton LA,Ramachandra-Rao S,Au E,Fliesler SJ

Thu Dec 22 00:00:00 UTC 2022

Aberrant Retinal Pigment Epithelial Cells Derived from Induced Pluripotent Stem Cells of a Retinitis Pigmentosa Patient with the PRPF6 Mutation.

International journal of molecular sciences

Liang Y,Tan F,Sun X,Cui Z,Gu J,Mao S,Chan HF,Tang S,Chen J

Fri Aug 12 00:00:00 UTC 2022

Aberrant Retinal Pigment Epithelial Cells Derived from Induced Pluripotent Stem Cells of a Retinitis Pigmentosa Patient with the PRPF6 Mutation.

International journal of molecular sciences

Liang Y,Tan F,Sun X,Cui Z,Gu J,Mao S,Chan HF,Tang S,Chen J

Fri Aug 12 00:00:00 UTC 2022

Müller Glia maintain their regenerative potential despite degeneration in the aged zebrafish retina.

Aging cell

Martins RR,Zamzam M,Tracey-White D,Moosajee M,Thummel R,Henriques CM,MacDonald RB

Fri Apr 01 00:00:00 UTC 2022

Direct conversion of human umbilical cord mesenchymal stem cells into retinal pigment epithelial cells for treatment of retinal degeneration.

Cell death & disease

Zhu X,Chen Z,Wang L,Ou Q,Feng Z,Xiao H,Shen Q,Li Y,Jin C,Xu JY,Gao F,Wang J,Zhang J,Zhang J,Xu Z,Xu GT,Lu L,Tian H

Mon Sep 12 00:00:00 UTC 2022

Direct conversion of human umbilical cord mesenchymal stem cells into retinal pigment epithelial cells for treatment of retinal degeneration.

Cell death & disease

Zhu X,Chen Z,Wang L,Ou Q,Feng Z,Xiao H,Shen Q,Li Y,Jin C,Xu JY,Gao F,Wang J,Zhang J,Zhang J,Xu Z,Xu GT,Lu L,Tian H

Mon Sep 12 00:00:00 UTC 2022

Determining the optimal stage for cryopreservation of human embryonic stem cell-derived retinal pigment epithelial cells.

Stem cell research & therapy

Zhang T,Huang X,Liu S,Bai X,Zhu X,Clegg DO,Jiang M,Sun X

Mon Sep 05 00:00:00 UTC 2022

A cell-penetrating CD40-TRAF2,3 blocking peptide diminishes inflammation and neuronal loss after ischemia/reperfusion.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Portillo JC,Yu JS,Hansen S,Kern TS,Subauste MC,Subauste CS

Mon Mar 01 00:00:00 UTC 2021

Spatiotemporal dynamics of inner ear sensory and non-sensory cells revealed by single-cell transcriptomics.

Cell reports

Jan TA,Eltawil Y,Ling AH,Chen L,Ellwanger DC,Heller S,Cheng AG

Tue Jul 13 00:00:00 UTC 2021

The astrocyte transcriptome in EAE optic neuritis shows complement activation and reveals a sex difference in astrocytic C3 expression.

Scientific reports

Tassoni A,Farkhondeh V,Itoh Y,Itoh N,Sofroniew MV,Voskuhl RR

Wed Jul 10 00:00:00 UTC 2019

CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy.

Diabetes

Portillo JC,Lopez Corcino Y,Miao Y,Tang J,Sheibani N,Kern TS,Dubyak GR,Subauste CS

Wed Feb 01 00:00:00 UTC 2017

CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy.

Diabetes

Portillo JC,Lopez Corcino Y,Miao Y,Tang J,Sheibani N,Kern TS,Dubyak GR,Subauste CS

Wed Feb 01 00:00:00 UTC 2017

AAV-mediated RLBP1 gene therapy improves the rate of dark adaptation in Rlbp1 knockout mice.

Molecular therapy. Methods & clinical development

Choi VW,Bigelow CE,McGee TL,Gujar AN,Li H,Hanks SM,Vrouvlianis J,Maker M,Leehy B,Zhang Y,Aranda J,Bounoutas G,Demirs JT,Yang J,Ornberg R,Wang Y,Martin W,Stout KR,Argentieri G,Grosenstein P,Diaz D,Turner O,Jaffee BD,Police SR,Dryja TP

Wed Jul 22 00:00:00 UTC 2015

AAV-mediated RLBP1 gene therapy improves the rate of dark adaptation in Rlbp1 knockout mice.

Molecular therapy. Methods & clinical development

Wed Jul 22 00:00:00 UTC 2015

Induction of ectopic retina-like tissue by transgenic expression of neurogenin.

PloS one

Yan RT,He L,Zhan W,Wang SZ

Tue Oct 06 00:00:00 UTC 2015

Induction of ectopic retina-like tissue by transgenic expression of neurogenin.

PloS one

Yan RT,He L,Zhan W,Wang SZ

Tue Oct 06 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Cellular retinaldehyde-binding protein; cellular retinaldehyde-binding protein-1; Retinaldehyde-binding protein 1

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Gene Aliases: 3110056M11Rik; CRALBP; RLBP1

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UniProt ID: (Human) P12271, (Mouse) Q9Z275

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Entrez Gene ID: (Human) 6017, (Mouse) 19771, (Rat) 293049

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Function(s)

transporter activity 11-cis retinal binding retinol binding molecular_function

Process(es)

retinoid metabolic process vitamin A metabolic process transport visual perception response to stimulus biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RLBP1 Polyclonal Antibody

RLBP1 Antibody (15356-1-AP) in IHC (P)

Product Details

15356-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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