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RMP Polyclonal Antibody

RMP Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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RMP Antibody (11277-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human lymphoma using 11277-1-AP (RMP antibody) at dilution of 1:50 (under 10x lens).

RMP Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11277-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RMP Fusion Protein Ag1789 (125-448 aa encoded by BC026184)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSDAAGDIV DIREEIKCDF EFKAKHRIAH KPHSKPKTSD IFEADIANDV KSKDLLADKE LWARLEELER QEELLGELDS KPDTVIANGE DTTSSEEEKE DRNTNVNAMH QVTDSHTPCH KDVASSEPFS GQVNSQLNCS VNGSSSYHSD DDDDDDDDDD DDNIDDDDGD NDHEALGVGD NSIPTIYFSH TVEPKRVRIN TGKNTTLKFS EKKEEAKRKR KNSTGSGHSA QELPTIRTPA DIYRAFVDVV NGEYVPRKSI LKSRSRENSV CSDTSESSAA EFDDRRGVLR SISCEEATCS DTSESILEEE PQENQKKLLP LSVT (125-448 aa encoded by B C026184)

Target Information

Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein. Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination. [Uniprot]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Macrophage Rmp Ameliorates Myocardial Infarction by Modulating Macrophage Polarization in Mice.

Oxidative medicine and cellular longevity

Zhang J,Yin Z,Yu L,Wang Z,Liu Y,Huang X,Wan S,Lan HY,Wang H

Tue Sep 13 00:00:00 UTC 2022

Macrophage Rmp Ameliorates Myocardial Infarction by Modulating Macrophage Polarization in Mice.

Oxidative medicine and cellular longevity

Zhang J,Yin Z,Yu L,Wang Z,Liu Y,Huang X,Wan S,Lan HY,Wang H

Tue Sep 13 00:00:00 UTC 2022

Macrophage Rmp Ameliorates Myocardial Infarction by Modulating Macrophage Polarization in Mice.

Oxidative medicine and cellular longevity

Zhang J,Yin Z,Yu L,Wang Z,Liu Y,Huang X,Wan S,Lan HY,Wang H

Tue Sep 13 00:00:00 UTC 2022

Cardiomyocyte-specific loss of RNA polymerase II subunit 5-mediating protein causes myocardial dysfunction and heart failure.

Cardiovascular research

Zhang J,Sheng J,Dong L,Xu Y,Yu L,Liu Y,Huang X,Wan S,Lan HY,Wang H

Sun Sep 01 00:00:00 UTC 2019

Cardiomyocyte-specific loss of RNA polymerase II subunit 5-mediating protein causes myocardial dysfunction and heart failure.

Cardiovascular research

Zhang J,Sheng J,Dong L,Xu Y,Yu L,Liu Y,Huang X,Wan S,Lan HY,Wang H

Sun Sep 01 00:00:00 UTC 2019

Cardiomyocyte-specific loss of RNA polymerase II subunit 5-mediating protein causes myocardial dysfunction and heart failure.

Cardiovascular research

Zhang J,Sheng J,Dong L,Xu Y,Yu L,Liu Y,Huang X,Wan S,Lan HY,Wang H

Sun Sep 01 00:00:00 UTC 2019

Cardiomyocyte-specific loss of RNA polymerase II subunit 5-mediating protein causes myocardial dysfunction and heart failure.

Cardiovascular research

Zhang J,Sheng J,Dong L,Xu Y,Yu L,Liu Y,Huang X,Wan S,Lan HY,Wang H

Sun Sep 01 00:00:00 UTC 2019

RMP promotes venous metastases of hepatocellular carcinoma through promoting IL-6 transcription.

Oncogene

Zhang J,Pan YF,Ding ZW,Yang GZ,Tan YX,Yang C,Jiang TY,Liu LJ,Zhang B,Han T,Cao D,Yang T,Yang N,Wu MC,Dong LW,Wang HY

Thu Mar 19 00:00:00 UTC 2015

RMP promotes venous metastases of hepatocellular carcinoma through promoting IL-6 transcription.

Oncogene

Zhang J,Pan YF,Ding ZW,Yang GZ,Tan YX,Yang C,Jiang TY,Liu LJ,Zhang B,Han T,Cao D,Yang T,Yang N,Wu MC,Dong LW,Wang HY

Thu Mar 19 00:00:00 UTC 2015

RMP predicts survival and adjuvant TACE response in hepatocellular carcinoma.

Oncotarget

Zhang J,Jiang TY,Jiang BG,Yang C,Tan YX,Yang N,Pan YF,Ding ZW,Yang GZ,Wu MC,Dong LW,Wang HY

Fri Feb 20 00:00:00 UTC 2015

RMP predicts survival and adjuvant TACE response in hepatocellular carcinoma.

Oncotarget

Zhang J,Jiang TY,Jiang BG,Yang C,Tan YX,Yang N,Pan YF,Ding ZW,Yang GZ,Wu MC,Dong LW,Wang HY

Fri Feb 20 00:00:00 UTC 2015

URI regulates tumorigenicity and chemotherapeutic resistance of multiple myeloma by modulating IL-6 transcription.

Cell death & disease

Fan JL,Zhang J,Dong LW,Fu WJ,Du J,Shi HG,Jiang H,Ye F,Xi H,Zhang CY,Hou J,Wang HY

Thu Mar 13 00:00:00 UTC 2014

URI regulates tumorigenicity and chemotherapeutic resistance of multiple myeloma by modulating IL-6 transcription.

Cell death & disease

Fan JL,Zhang J,Dong LW,Fu WJ,Du J,Shi HG,Jiang H,Ye F,Xi H,Zhang CY,Hou J,Wang HY

Thu Mar 13 00:00:00 UTC 2014

URI regulates tumorigenicity and chemotherapeutic resistance of multiple myeloma by modulating IL-6 transcription.

Cell death & disease

Fan JL,Zhang J,Dong LW,Fu WJ,Du J,Shi HG,Jiang H,Ye F,Xi H,Zhang CY,Hou J,Wang HY

Thu Mar 13 00:00:00 UTC 2014

URI regulates tumorigenicity and chemotherapeutic resistance of multiple myeloma by modulating IL-6 transcription.

Cell death & disease

Fan JL,Zhang J,Dong LW,Fu WJ,Du J,Shi HG,Jiang H,Ye F,Xi H,Zhang CY,Hou J,Wang HY

Thu Mar 13 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: FLJ10575; Protein NNX3; Protein phosphatase 1 regulatory subunit 19; protein phosphatase 1, regulatory subunit 19; RNA polymerase II subunit 5-mediating protein; RPB5-mediating protein; Unconventional prefoldin RPB5 interactor; Unconventional prefoldin RPB5 interactor 1; URI1 prefoldin-like chaperone

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Gene Aliases: C19orf2; C80913; NNX3; PPP1R19; RMP; URI; URI1

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UniProt ID: (Human) O94763, (Mouse) Q3TLD5

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Entrez Gene ID: (Human) 8725, (Mouse) 19777

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Function(s)

RNA polymerase II transcription corepressor activity chromatin binding protein phosphatase inhibitor activity protein binding phosphatase inhibitor activity phosphoprotein binding

Process(es)

negative regulation of transcription from RNA polymerase II promoter regulation of cell growth transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter response to virus negative regulation of phosphatase activity cellular response to growth factor stimulus cellular response to steroid hormone stimulus negative regulation of intrinsic apoptotic signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RMP Polyclonal Antibody

RMP Antibody (11277-1-AP) in IHC (P)

Product Details

11277-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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