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RNASEL Polyclonal Antibody

RNASEL Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 6

RNASEL Antibody (22577-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 22577-1-AP (RNASEL antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IGG.

RNASEL Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

22577-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RNASEL Fusion Protein Ag17409 (392-741 aa encoded by BC115697)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KTFCEGSPR AQREVSCLQS SRENSHLVTF YGSESHRGHL FVCVTLCEQT LEACLDVHRG EDVENEEDEF AQNVLSSIFK AVQELHLSCG YTHQDLQPQN ILIDSKKAAH LADFDKSIKW AGDPQEVKRD LEDLGRLVLY VVKKGSISFE ELKAQSNEEV VQLSPDEETK DLIHRLFHPG EHVRDCLSDL LGHPFFWTWE SRYRTLRNVG NESDIKTRKS ESEILRLLQP GPSEHSKSFD KWTTKINECV MKKMNKFYEK RGNFYQNTVG DLLKFIRNLG EHIDEEKHKK MKLKIGDPSL YFQKTFPDLV IYVYTKLQNT EYRKHFPQTH SPNKPQCDGA GGASGLASPG C (392-741 aa encoded by BC115697)

Target Information

A virally induced endoribonuclease, RNase L is the terminal factor of the anti-viral action of interferon. Activation of RNase L results in inhibition of viral proliferation. Activation of RNase L has also been determined to degrade RNA, thus, initiating a cellular stress response, inducing apoptosis. Since mutations in RNase L relate to an increased incidence of prostate cancer, the activation of RNase L functions in counteracting prostate cancer, via apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

IFN-β1b induces OAS3 to inhibit EV71 via IFN-β1b/JAK/STAT1 pathway.

Virologica Sinica

Zheng B,Zhou X,Tian L,Wang J,Zhang W

Sat Oct 01 00:00:00 UTC 2022

Deficiency of ER Ca²⁺ sensor STIM1 in AgRP neurons confers protection against dietary obesity.

Cell reports

Chen Z,Pan S,Yin K,Zhang Y,Yuan X,Wang S,Yang S,Shen Q,Tang Y,Li J,Wang Y,Lu Y,Zhang G

Tue Oct 19 00:00:00 UTC 2021

The function of RNase L and its degradation mechanism in cardiac acute ischemic injury.

Apoptosis : an international journal on programmed cell death

Ma Q,Li J,Zhou H,Tong W,Chen Y

Mon Jun 01 00:00:00 UTC 2020

Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression.

iScience

Fu Y,Fang Y,Lin Z,Yang L,Zheng L,Hu H,Yu T,Huang B,Chen S,Wang H,Xu S,Bao W,Chen Q,Sun L

Fri Apr 24 00:00:00 UTC 2020

The CRISPR-Cas13a Gene-Editing System Induces Collateral Cleavage of RNA in Glioma Cells.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Wang Q,Liu X,Zhou J,Yang C,Wang G,Tan Y,Wu Y,Zhang S,Yi K,Kang C

Wed Oct 16 00:00:00 UTC 2019

Human serum RNase-L level is inversely associated with metabolic syndrome and age.

Cardiovascular diabetology

Wang YT,Tseng PH,Chen CL,Han DS,Chi YC,Tseng FY,Yang WS

Tue Apr 11 00:00:00 UTC 2017

Human serum RNase-L level is inversely associated with metabolic syndrome and age.

Cardiovascular diabetology

Wang YT,Tseng PH,Chen CL,Han DS,Chi YC,Tseng FY,Yang WS

Tue Apr 11 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: 2',5'-oligoisoadenylate synthetase-dependent; 2-5A-dependent ribonuclease; 2-5A-dependent RNAase; 2-5A-dependent RNase; interferon-induced 2-5A-dependent RNase; Ribonuclease 4; Ribonuclease L; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent); RNase L

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Gene Aliases: E230029I04Rik; PRCA1; RNASEL; RNS4

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UniProt ID: (Human) Q05823, (Mouse) Q05921

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Entrez Gene ID: (Human) 6041, (Mouse) 24014

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Function(s)

RNA binding endoribonuclease activity protein kinase activity protein binding ATP binding rRNA binding ribonucleoprotein complex binding metal ion binding nucleotide binding nuclease activity endonuclease activity ribonuclease activity bidentate ribonuclease III activity transferase activity, transferring phosphorus-containing groups hydrolase activity

Process(es)

rRNA processing mRNA processing protein phosphorylation regulation of mRNA stability negative regulation of viral genome replication fat cell differentiation positive regulation of transcription from RNA polymerase II promoter defense response to virus RNA phosphodiester bond hydrolysis positive regulation of glucose import in response to insulin stimulus transmembrane transport type I interferon signaling pathway RNA phosphodiester bond hydrolysis, endonucleolytic

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RNASEL Polyclonal Antibody

RNASEL Antibody (22577-1-AP) in ICC/IF

Product Details

22577-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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