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Product Details
PA5-34346
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 16 amino acid synthetic peptide near the carboxy terminus of human RNASET2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2551698
Product Specific Information
A suggested positive control is SW480 cell lysate.
PA5-34346 can be used with blocking peptide PEP-1389.
Target Information
RNASET2 is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement, and has been suggested to function as a tumor suppressor protein. Its expression is suppressed in Human T-cell Leukemia Virus type 1 (HTLV-1) infected cells following the binding of the HTLV-1 Tax protein to the RNASET2 promoter. As Adult T-cell leukemia (ATL) is one of the primary diseases caused by HTLV-1 infection, a reduction in the level of RNASET2 by Tax may play a role in ATL development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ribonuclease 6; Ribonuclease 6-A; Ribonuclease 6-B; Ribonuclease T2; Ribonuclease T2-A; Ribonuclease T2-B; RNase T2; rnt2; RP11-514O12.3
Gene Aliases: 0610007O07Rik; 4833423A10Rik; 4930532K22Rik; bA514O12.3; C79750; RNASE6PL; RNASET2; Rnaset2a; Rnaset2b
UniProt ID: (Human) O00584, (Mouse) C0HKG5
Entrez Gene ID: (Human) 8635, (Rat) 292306, (Mouse) 100037283
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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