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Product Details
66228-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig
Published species
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
3H8F9
Immunogen
RND3 Fusion Protein Ag18839 (1-244 aa encoded by BC012513)
Conjugate
Form
Liquid
Concentration
1.37 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MKERRASQK LSSKSIMDPN QNVKCKIVVV GDSQCGKTAL LHVFAKDCFP ENYVPTVFEN YTASFEIDTQ RIELSLWDTS GSPYYDNVRP LSYPDSDAVL ICFDISRPET LDSVLKKWKG EIQEFCPNTK MLLVGCKSDL RTDVSTLVEL SNHRQTPVSY DQGANMAKQI GAATYIECSA LQSENSVRDI FHVATLACVN KTNKNVKRNK SQRATKRISH MPSRPELSAV ATDLRKDKAK SCTVM (1-244 aa encoded by BC012513)
Target Information
Members of the Rho family of Ras-related GTPases, such as ARHE, regulate the organization of the actin cytoskeleton in response to extracellular growth factors. Like Ras, Rho family members appear to cycle between an inactive GDP-bound form and an active GTP-bound form. Three major regulators of Rho activity have been identified: RhoGDIs, which interact with the GDP-bound Rho proteins to keep them in a resting complex; GEFs, which promote GDP/GTP exchange leading to activation of Rho proteins; and GAPs, which stimulate GTP hydrolysis and return the activated Rho protein to its inactive form.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MemB protein; Protein MemB; ras homolog gene family, member E; Rho family GTPase 3; Rho related protein Rnd3/Rho8; Rho-related GTP-binding protein Rho8; Rho-related GTP-binding protein RhoE; rho8; Rnd3; small GTP binding protein Rho8
Gene Aliases: ARHE; memB; RHO8; RHOE; RND3
UniProt ID: (Human) P61587, (Pig) O77683
Entrez Gene ID: (Human) 390, (Pig) 397559
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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