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Product Details
16948-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RNF11 Fusion Protein Ag10563 (1-154 aa encoded by BC020964)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGNCLKSPT SDDISLLHES QSDRASFGEG TEPDQEPPPP YQEQVPVPVY HPTPSQTRLA TQLTEEEQIR IAQRIGLIQH LPKGVYDPGR DGSEKKIREC VICMMDFVYG DPIRFLPCMH IYHLDCIDDW LMRSFTCPSC MEPVDAALLS SYETN (1-154 aa encoded by BC020964)
Target Information
Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: NEDD4 WW domain-binding protein 2; RING finger protein 11; Sid 1669
Gene Aliases: CGI-123; N4wbp2; RNF11; SID1669
UniProt ID: (Human) Q9Y3C5, (Mouse) Q9QYK7
Entrez Gene ID: (Human) 26994, (Mouse) 29864
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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