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Abnova
RNF111 Polyclonal Antibody, MaxPab™
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Product Details
H00054778-D01P
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RNF111 (AAH60862.1, 1 a.a. approximately 985 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSQWTPEYKE LYTLKVDMKS EIPSDAPKTQ ESLKGILLHP EPIGAAKSFP AGVEMINSKV GNEFSHLCDD SQKQEKEMNG NQQEQEKSLV VRKKRKSQQA GPSYVQNCVK ENQGILGLRQ HLGTPSDEDN DSSFSDCLSS PSSSLHFGDS DTVTSDEDKE VSVRHSQTIL NAKSRSHSAR SHKWPRTETE SVSGLLMKRP CLHGSSLRRL PCRKRFVKNN SSQRTQKQKE RILMQRKKRE VLARRKYALL PSSSSSSEND LSSESSSSSS TEGEEDLFVS ASENHQNNPA VPSGSIDEDV VVIEASSTPQ VTANEEINVT STDSEVEIVT VGESYRSRST LGHSRSHWSQ GSSSHASRPQ EPRNRSRIST VIQPLRQNAA EVVDLTVDED EPTVVPTTSA RMESQATSAS INNSNPSTSE QASDTASAVT SSQPSTVSET SATLTSNSTT GTSIGDDSRR TTSSAVTETG PPAMPRLPSC CPQHSPCGGS SQNHHALGHP HTSCFQQHGH HFQHHHHHHH TPHPAVPVSP SFSDPACPVE RPPQVQAPCG ANSSSGTSYH EQALPVDLSN SGIRSHGSGS FHGASAFDPC CPVSSSRAAI FGHQAAAAAP SQPLSSIDGY GSSMVAQPQP QPPPQPSLSS CRHYMPPPYA SLTRPLHHQA SACPHSHGNP PPQTQPPPQV DYVIPHPVHA FHSQISSHAT SHPVAPPPPT HLASTAAPIP QHLPPTHQPI SHHIPATAPP AQRLHPHEVM QRMEVQRRRM MQHPTRAHER PPPHPHRMHP NYGHGHHIHV PQTMSSHPRQ APERSAWELG IEAGVTAATY TPGALHPHLA HYHAPPRLHH LQLGALPLMV PDMAGYPHIR YISSGLDGTS FRGPFRGNFE ELIHLEERLG NVNRGASQGT IERCTYPHKY KKRKLHCKQD GEEGTEEDTE EKCTICLSIL EEGEDVRRLP CMHLFHQVCV DQWLITNKKC PICRVDIEAQ LPSES
Target Information
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Arkadia; E3 ubiquitin-protein ligase Arkadia; hRNF111; RING finger protein 111; RING-type E3 ubiquitin transferase Arkadia
Gene Aliases: ARK; Arkadia; RNF111
UniProt ID: (Human) Q6ZNA4, (Mouse) Q99ML9
Entrez Gene ID: (Human) 54778, (Mouse) 93836
protein binding
zinc ion binding
ligase activity
SUMO polymer binding
SMAD binding
ubiquitin protein ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
protein polyubiquitination
multicellular organism development
pattern specification process
protein ubiquitination
positive regulation of transforming growth factor beta receptor signaling pathway
ubiquitin-dependent SMAD protein catabolic process
positive regulation of protein ubiquitination
positive regulation of transcription, DNA-templated
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of transcription from RNA polymerase II promoter
global genome nucleotide-excision repair
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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