Proteintech

RNF156 Polyclonal Antibody

RNF156 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 11

RNF156 Antibody (11285-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 11285-1-AP ( RNF156 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Product Image Gallery

Product Details

11285-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RNF156 Fusion Protein Ag1808 (277-576 aa encoded by BC014199)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SDDENSDNS NECVVCLSDL RDTLILPCRH LCLCTSCADT LRYQANNCPI CRLPFRALLQ IRAVRKKPGA LSPVSFSPVL AQSLEHDEHS CPFKKSKPHP ASLASKKPKR ETNSDSVPPG YEPISLLEAL NGLRAVSPAI PSAPLYEEIT YSGISDGLSQ ASCPLAAIDH ILDSSRQKGR PQSKAPDSTL RSPSSPIHEE DEEKLSEDVD APPPLGGAEL ALRESSSPES FITEEVDESS SPQQGTRAAS IENVLQDSSP EHCGRGPPAD IYLPGRPTSM ETAHGLATTS PTWPPLGGPS PDPSAAELTP L (277-576 aa encoded by BC014199)

Target Information

Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength.

Development (Cambridge, England)

Kong JH,Young CB,Pusapati GV,Espinoza FH,Patel CB,Beckert F,Ho S,Patel BB,Gabriel GC,Aravind L,Bazan JF,Gunn TM,Lo CW,Rohatgi R

Fri Oct 01 00:00:00 UTC 2021

Promoter Methylation of the MGRN1 Gene Predicts Prognosis and Response to Chemotherapy of High-Grade Serous Ovarian Cancer Patients.

Frontiers in oncology

Li XF,Sun HY,Hua T,Zhang HB,Tian YJ,Li Y,Kang S

Sat Jul 17 00:00:00 UTC 2021

Promoter Methylation of the MGRN1 Gene Predicts Prognosis and Response to Chemotherapy of High-Grade Serous Ovarian Cancer Patients.

Frontiers in oncology

Li XF,Sun HY,Hua T,Zhang HB,Tian YJ,Li Y,Kang S

Sat Jul 17 00:00:00 UTC 2021

A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development.

Developmental cell

Kong JH,Young CB,Pusapati GV,Patel CB,Ho S,Krishnan A,Lin JI,Devine W,Moreau de Bellaing A,Athni TS,Aravind L,Gunn TM,Lo CW,Rohatgi R

Mon Nov 23 00:00:00 UTC 2020

Chronic and age-dependent effects of the spongiform neurodegeneration-associated MGRN1 E3 ubiquitin ligase on mitochondrial homeostasis.

Mammalian genome : official journal of the International Mammalian Genome Society

Gunn TM,Silvius D,Lester A,Gibbs B

Sat Jun 01 00:00:00 UTC 2019

Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival.

Molecular cell

Benvegnù S,Mateo MI,Palomer E,Jurado-Arjona J,Dotti CG

Thu May 04 00:00:00 UTC 2017

Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival.

Molecular cell

Benvegnù S,Mateo MI,Palomer E,Jurado-Arjona J,Dotti CG

Thu May 04 00:00:00 UTC 2017

Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival.

Molecular cell

Benvegnù S,Mateo MI,Palomer E,Jurado-Arjona J,Dotti CG

Thu May 04 00:00:00 UTC 2017

Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival.

Molecular cell

Benvegnù S,Mateo MI,Palomer E,Jurado-Arjona J,Dotti CG

Thu May 04 00:00:00 UTC 2017

MGRN1-dependent pigment-type switching requires its ubiquitination activity but not its interaction with TSG101 or NEDD4.

Pigment cell & melanoma research

Gunn TM,Silvius D,Bagher P,Sun K,Walker KK

Fri Mar 01 00:00:00 UTC 2013

MGRN1-dependent pigment-type switching requires its ubiquitination activity but not its interaction with TSG101 or NEDD4.

Pigment cell & melanoma research

Gunn TM,Silvius D,Bagher P,Sun K,Walker KK

Fri Mar 01 00:00:00 UTC 2013

Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein.

The Journal of biological chemistry

Overton JD,Leibel RL

Fri May 27 00:00:00 UTC 2011

Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein.

The Journal of biological chemistry

Overton JD,Leibel RL

Fri May 27 00:00:00 UTC 2011

Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein.

The Journal of biological chemistry

Overton JD,Leibel RL

Fri May 27 00:00:00 UTC 2011

Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein.

The Journal of biological chemistry

Overton JD,Leibel RL

Fri May 27 00:00:00 UTC 2011

Abnormal regulation of TSG101 in mice with spongiform neurodegeneration.

Biochimica et biophysica acta

Jiao J,Sun K,Walker WP,Bagher P,Cota CD,Gunn TM

Thu Oct 01 00:00:00 UTC 2009

Abnormal regulation of TSG101 in mice with spongiform neurodegeneration.

Biochimica et biophysica acta

Jiao J,Sun K,Walker WP,Bagher P,Cota CD,Gunn TM

Thu Oct 01 00:00:00 UTC 2009

Bioinformatics

Protein Aliases: E3 ubiquitin-protein ligase MGRN1; mahoganoid; mahogunin ring finger 1, E3 ubiquitin protein ligase; Mahogunin RING finger protein 1; mahogunin, ring finger 1; probable E3 ubiquitin-protein ligase MGRN1; RING finger protein 156; RING-type E3 ubiquitin transferase MGRN1

View more View less

Gene Aliases: 2610042J20Rik; KIAA0544; md; MGRN1; mKIAA0544; nc; RGD1311862; RNF156

View more View less

UniProt ID: (Human) O60291, (Rat) Q5XIQ4, (Mouse) Q9D074

View more View less

Entrez Gene ID: (Human) 23295, (Rat) 302938, (Mouse) 17237

View more View less

Function(s)

ubiquitin-protein transferase activity protein binding zinc ion binding ligase activity ubiquitin protein ligase activity molecular_function UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity

Process(es)

protein polyubiquitination protein monoubiquitination endosome to lysosome transport negative regulation of cAMP-mediated signaling negative regulation of G-protein coupled receptor protein signaling pathway biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

RNF156 Polyclonal Antibody

RNF156 Antibody (11285-1-AP) in IHC (P)

Product Details

11285-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!