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Invitrogen
RNF19A Polyclonal Antibody
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RNF19A Antibody (PA5-103251) in IHC (P)
Immunohistochemistry analysis of RNF19A in human esophageal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with RNF19A polyclonal antibody (Product # PA5-103251) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-103251
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RNF19A(Accession Q9NV58), corresponding to amino acid residues S52-C102.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2852614
Product Specific Information
Antibody detects endogenous levels of total RNF19A.
Target Information
This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dorfin; Double ring-finger protein; E3 ubiquitin-protein ligase RNF19A; Gametogenesis-expressed protein GEG-154; p38; protein p38 interacting with transcription factor Sp1; ring finger protein (C3HC4 type) 19; ring finger protein 19; RING finger protein 19A; ring finger protein 19A, E3 ubiquitin protein ligase; ring-IBR-ring domain containing protein Dorfin; UBCM4-interacting protein 117; ubiquitin conjugating enzyme 7 interacting protein 2; UIP117; XY body protein; XYbp
Gene Aliases: AA032313; Dorfin; Geg-154; RNF19; RNF19A; Ubce7ip2; UIP117; XYbp
UniProt ID: (Human) Q9NV58, (Mouse) P50636
Entrez Gene ID: (Human) 25897, (Mouse) 30945
ubiquitin-protein transferase activity
transcription factor binding
zinc ion binding
ligase activity
ubiquitin conjugating enzyme binding
ubiquitin protein ligase activity
protein binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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