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Invitrogen
RNF4 Monoclonal Antibody (OTI9F10)
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Product Details
MA5-27424
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI9F10
Immunogen
Human recombinant protein fragment corresponding to amino acids 1-190 of RNF4 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2723591
Target Information
The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin ligase RNF4; E3 ubiquitin-protein ligase RNF4; Protein SNURF; RING finger protein 4; Small nuclear ring finger protein; SNURF
Gene Aliases: AU018689; Gtrgeo8; RES4-26; RNF4; SLX5; SNURF
UniProt ID: (Human) P78317, (Rat) O88846, (Mouse) Q9QZS2
Entrez Gene ID: (Human) 6047, (Rat) 29274, (Mouse) 19822
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
ubiquitin-protein transferase activity
protein binding
transcription factor binding
zinc ion binding
ligase activity
nucleosome binding
SUMO polymer binding
identical protein binding
androgen receptor binding
ubiquitin protein ligase activity
TBP-class protein binding
estrogen receptor binding
progesterone receptor binding
transcription, DNA-templated
protein ubiquitination
androgen receptor signaling pathway
negative regulation of protein sumoylation
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to arsenic-containing substance
protein autoubiquitination
protein K63-linked ubiquitination
protein K48-linked ubiquitination
protein K11-linked ubiquitination
protein K6-linked ubiquitination
regulation of spindle assembly
regulation of kinetochore assembly
negative regulation of cell death
cellular response to gamma radiation
cellular response to hydroxyurea
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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