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Invitrogen
RNF8 Polyclonal Antibody
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Product Details
PA5-111592
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human RNF8. Recombinant protein control fragment (Product #RP-107386).
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2857002
Product Specific Information
Immunogen sequence: CEVTVGRGFG VTYQLVSKIC PLMISRNHCV LKQNPEGQWT IMDNKSLNGV WLNRARLEPL RVYSIHQGDY IQLGVPLENK ENAEYEYEVT EEDWETIYPC LSPKNDQMI
Target Information
The protein encoded by this gene contains a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C3HC4-type zinc finger protein; E3 ubiquitin-protein ligase RNF8; FLJ12013; hRNF8; OTTHUMP00000039684; ring finger protein (C3HC4 type) 8; RING finger protein 8; ring finger protein 8, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF8; UBC13/UEV-interacting ring finger protein
Gene Aliases: hRNF8; KIAA0646; RNF8
UniProt ID: (Human) O76064
Entrez Gene ID: (Human) 9025
double-strand break repair
double-strand break repair via nonhomologous end joining
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
mitotic nuclear division
spermatid development
response to ionizing radiation
histone H2A ubiquitination
histone H2B ubiquitination
negative regulation of transcription elongation from RNA polymerase II promoter
interstrand cross-link repair
histone exchange
isotype switching
positive regulation of DNA repair
cell division
protein autoubiquitination
protein K63-linked ubiquitination
histone H2A K63-linked ubiquitination
protein K48-linked ubiquitination
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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