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Proteintech
RNase T2 Polyclonal Antibody
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FIGURE: 1 / 6
RNase T2 Antibody (13753-1-AP) in ICC/IF
IF result of 13753-1-AP (anti-RNASET2) in COS7 cell by Dr. Nancy Kedersha. COS7 cells transiently transfected with FAST-KD4-YFP, counterstained with PTG RNASET2 antibody (red) and human anti-mitochondrial antigen in blue. Note that FAST-KD4-YFP overexpression alters mitchonrial morphology, and is also present at stress granules (green only).
Product Details
13753-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RNase T2 Fusion Protein Ag4695 (25-256 aa encoded by BC039713)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DKRLRDNHE WKKLIMVQHW PETVCEKIQN DCRDPPDYWT IHGLWPDKSE GCNRSWPFNL EEIKDLLPEM RAYWPDVIHS FPNRSRFWKH EWEKHGTCAA QVDALNSQKK YFGRSLELYR ELDLNSVLLK LGIKPSINYY QVADFKDALA RVYGVIPKIQ CLPPSQDEEV QTIGQIELCL TKQDQQLQNC TEPGEQPSPK QEVWLANGAA ESRGLRVCED GPVFYPPPKK TKH (25-256 aa encoded by BC039713)
Target Information
RNASET2 is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement, and has been suggested to function as a tumor suppressor protein. Its expression is suppressed in Human T-cell Leukemia Virus type 1 (HTLV-1) infected cells following the binding of the HTLV-1 Tax protein to the RNASET2 promoter. As Adult T-cell leukemia (ATL) is one of the primary diseases caused by HTLV-1 infection, a reduction in the level of RNASET2 by Tax may play a role in ATL development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Ribonuclease 6; Ribonuclease 6-A; Ribonuclease 6-B; Ribonuclease T2; Ribonuclease T2-A; Ribonuclease T2-B; RNase T2; rnt2; RP11-514O12.3
Gene Aliases: 0610007O07Rik; 4833423A10Rik; 4930532K22Rik; bA514O12.3; C79750; RNASE6PL; RNASET2; Rnaset2a; Rnaset2b
UniProt ID: (Human) O00584, (Mouse) C0HKG5
Entrez Gene ID: (Human) 8635, (Mouse) 100037283
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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