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Invitrogen
RNaseL Recombinant Rabbit Monoclonal Antibody (HL2341)
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FIGURE: 1 / 5
RNaseL Antibody (MA5-50495) in WB
Western Blot analysis of RNaseL using RNaseL Recombinant Monoclonal Antibody (Product # MA5-50495) in K562 (30 μg), THP-1 (30 μg), and HL-60 (30 μg) whole cell extracts at a dilution of 1:1,000. Extracts were separated by 7.5% SDS-PAGE. An HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Product Details
MA5-50495
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL2341
Immunogen
Recombinant fragment of human RNase L.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3093935
Target Information
A virally induced endoribonuclease, RNase L is the terminal factor of the anti-viral action of interferon. Activation of RNase L results in inhibition of viral proliferation. Activation of RNase L has also been determined to degrade RNA, thus, initiating a cellular stress response, inducing apoptosis. Since mutations in RNase L relate to an increased incidence of prostate cancer, the activation of RNase L functions in counteracting prostate cancer, via apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2',5'-oligoisoadenylate synthetase-dependent; 2-5A-dependent ribonuclease; 2-5A-dependent RNAase; 2-5A-dependent RNase; interferon-induced 2-5A-dependent RNase; Ribonuclease 4; Ribonuclease L; ribonuclease L (2 5-oligoisoadenylate synthetase-dependent); ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent); ribonuclease L (2, 5-oligoisoadenylate synthetase-dependent); RNase L
Gene Aliases: E230029I04Rik; PRCA1; RNASEL; RNS4
UniProt ID: (Human) Q05823, (Mouse) Q05921
Entrez Gene ID: (Human) 6041, (Dog) 490310, (Mouse) 24014, (Rat) 359726
RNA binding
endoribonuclease activity
protein kinase activity
protein binding
ATP binding
rRNA binding
ribonucleoprotein complex binding
metal ion binding
nucleotide binding
nuclease activity
endonuclease activity
ribonuclease activity
bidentate ribonuclease III activity
transferase activity, transferring phosphorus-containing groups
hydrolase activity
rRNA processing
mRNA processing
protein phosphorylation
regulation of mRNA stability
negative regulation of viral genome replication
fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
RNA phosphodiester bond hydrolysis
positive regulation of glucose import in response to insulin stimulus
transmembrane transport
type I interferon signaling pathway
RNA phosphodiester bond hydrolysis, endonucleolytic
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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