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Rockland
ROC1 Polyclonal Antibody
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Product Details
100-401-A13
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 94-108 of Human ROC1 (C-terminal) coupled to KLH.
Conjugate
Form
Liquid
Concentration
85 mg/mL
Storage buffer
whole serum
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This product reacts with human, mouse, C.elgans and zebra fish ROC1. Cross reactivity may also occur with ROC1 from other sources. Sufficient sequence differences exist to suggest that this antibody would not react with other RING box proteins such as ROC2 and APC11.
Target Information
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase RBX1; E3 ubiquitin-protein transferase RBX1; Protein ZYP; Rbx1; Regulator of cullins 1; RING box protein 1; RING finger protein 75; ring-box 1, E3 ubiquitin protein ligase; RING-box protein 1; ROC1; ZYP protein
Gene Aliases: BA554C12.1; RBX1; RNF75; ROC1
UniProt ID: (Human) P62877
Entrez Gene ID: (Human) 9978
MAPK cascade
protein polyubiquitination
nucleotide-excision repair, DNA damage recognition
nucleotide-excision repair, DNA duplex unwinding
transcription-coupled nucleotide-excision repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
protein monoubiquitination
viral process
Wnt signaling pathway
protein ubiquitination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
nucleotide-excision repair, DNA incision
DNA damage response, detection of DNA damage
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
protein neddylation
regulation of transcription from RNA polymerase II promoter in response to hypoxia
global genome nucleotide-excision repair
negative regulation of canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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