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Invitrogen
ROC1 Polyclonal Antibody
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Product Details
PA5-109256
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within Human RBX1 aa 1-108
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2854667
Product Specific Information
Positive Control: HepG2, 293T, MCF-7, human colon cancer tissue, human stomach cancer tissue, mouse colon tissue, human placenta tissue.
Target Information
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase RBX1; E3 ubiquitin-protein transferase RBX1; Protein ZYP; Rbx1; Regulator of cullins 1; RING box protein 1; RING finger protein 75; ring-box 1, E3 ubiquitin protein ligase; RING-box protein 1; ROC1; ZYP protein
Gene Aliases: BA554C12.1; RBX1; RNF75; ROC1
UniProt ID: (Human) P62877
Entrez Gene ID: (Human) 9978
MAPK cascade
protein polyubiquitination
nucleotide-excision repair, DNA damage recognition
nucleotide-excision repair, DNA duplex unwinding
transcription-coupled nucleotide-excision repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
protein monoubiquitination
viral process
Wnt signaling pathway
protein ubiquitination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
nucleotide-excision repair, DNA incision
DNA damage response, detection of DNA damage
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
protein neddylation
regulation of transcription from RNA polymerase II promoter in response to hypoxia
global genome nucleotide-excision repair
negative regulation of canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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