Invitrogen

ROC1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-29149

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human RBX1. The exact sequence is proprietary.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 10% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2546625

Product Specific Information

Recommended positive controls: mouse brain.

Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (100%), Chicken (100%), Bovine (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: E3 ubiquitin-protein ligase RBX1; E3 ubiquitin-protein transferase RBX1; Protein ZYP; Rbx1; Regulator of cullins 1; RING box protein 1; RING finger protein 75; ring-box 1, E3 ubiquitin protein ligase; RING-box protein 1; ROC1; ZYP protein

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Gene Aliases: 1500002P15Rik; AA517855; BA554C12.1; RBX1; RNF75; ROC1

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UniProt ID: (Human) P62877, (Mouse) P62878

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Entrez Gene ID: (Human) 9978, (Mouse) 56438

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Function(s)
ubiquitin-protein transferase activity protein binding zinc ion binding ligase activity NEDD8 transferase activity ubiquitin protein ligase binding protein complex binding ubiquitin-ubiquitin ligase activity ubiquitin protein ligase activity cullin family protein binding eukaryotic initiation factor 4E binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity
Process(es)
DNA repair ubiquitin-dependent protein catabolic process protein monoubiquitination cellular response to DNA damage stimulus protein ubiquitination protein catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination involved in ubiquitin-dependent protein catabolic process protein neddylation MAPK cascade protein polyubiquitination nucleotide-excision repair, DNA damage recognition nucleotide-excision repair, DNA duplex unwinding transcription-coupled nucleotide-excision repair nucleotide-excision repair, preincision complex stabilization nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 3'-to lesion nucleotide-excision repair, DNA incision, 5'-to lesion viral process Wnt signaling pathway nucleotide-excision repair, DNA incision DNA damage response, detection of DNA damage proteasome-mediated ubiquitin-dependent protein catabolic process regulation of transcription from RNA polymerase II promoter in response to hypoxia global genome nucleotide-excision repair negative regulation of canonical Wnt signaling pathway
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