Invitrogen

ROCK1/ROCK2 Recombinant Rabbit Monoclonal Antibody (HL1632)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-50324

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:10,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL1632

Immunogen

Recombinant fragment of human ROCK1 .

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3093954

Target Information

ROCK1 and ROCK2 are genes that encode for Rho-associated coiled-coil containing protein kinases, also known as ROCKs. These kinases are involved in a variety of cellular processes such as cell migration, adhesion, proliferation, and apoptosis. They are activated by the small GTPase RhoA and phosphorylate downstream targets such as myosin light chain, LIM kinase, and myosin phosphatase. Dysregulation of ROCK1 and ROCK2 has been linked to various diseases including cancer, cardiovascular disease, and neurological disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: p160 ROCK-1; p160ROCK; p164 ROCK-2; Renal carcinoma antigen NY-REN-35; Rho kinase 2; Rho-associated protein kinase 1; Rho-associated protein kinase 2; Rho-associated, coiled-coil containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase I; Rho-associated, coiled-coil-containing protein kinase II; ROCK-1/ROCK-2; ROCK-I; ROCK-I/ROCK-II; ROCK-II

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Gene Aliases: KIAA0619; P160ROCK; ROCK-I; ROCK-II; ROCK1; ROCK2

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UniProt ID: (Human) Q13464, (Human) O75116

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Entrez Gene ID: (Human) 6093, (Human) 9475

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Function(s)
protein kinase activity protein serine/threonine kinase activity protein binding ATP binding GTP-Rho binding metal ion binding structural molecule activity Rho GTPase binding poly(A) RNA binding Rho-dependent protein serine/threonine kinase activity
Process(es)
apical constriction protein phosphorylation cellular component disassembly involved in execution phase of apoptosis smooth muscle contraction leukocyte cell-cell adhesion signal transduction I-kappaB kinase/NF-kappaB signaling Rho protein signal transduction negative regulation of angiogenesis membrane to membrane docking actin cytoskeleton organization regulation of cell adhesion cortical actin cytoskeleton organization bleb assembly negative regulation of protein binding regulation of actin cytoskeleton organization negative regulation of myosin-light-chain-phosphatase activity negative regulation of neuron apoptotic process regulation of keratinocyte differentiation vascular endothelial growth factor receptor signaling pathway ephrin receptor signaling pathway leukocyte migration leukocyte tethering or rolling myoblast migration regulation of stress fiber assembly regulation of focal adhesion assembly positive regulation of focal adhesion assembly establishment of protein localization to plasma membrane regulation of establishment of endothelial barrier negative regulation of bicellular tight junction assembly regulation of establishment of cell polarity regulation of cell motility cytokinesis positive regulation of protein phosphorylation positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of centrosome duplication regulation of circadian rhythm rhythmic process centrosome duplication cellular response to testosterone stimulus
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