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Proteintech
ROCK2 Monoclonal Antibody (1C7B8)
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Product Details
66633-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1C7B8
Immunogen
ROCK2 Fusion Protein Ag16330 (1-181 aa encoded by BC111801)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is specific to ROCK2.
Immunogen sequence: MEIDMTYQL KVIQQSLEQE EAEHKATKAR LADKNKIYES IEEAKSEAMK EMEKKLLEER TLKQKVENLL LEAEKRCSLL DCDLKQSQQK INELLKQKDV LNEDVRNLTL KIEQETQKRC LTQNDLKMQT QQVNTLKMSE KQLKQENNHL MEMKMNLEKQ NAELRKERQD ADGQMKELQD QL (1-181 aa encoded by BC111801)
Target Information
ROCK2, the predominant ROCK isoform in skeletal muscle, is an important regulator downstream of Rho GTPases. ROCK2 regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: p150 ROK-alpha; p164 ROCK-2; Rho kinase 2; Rho-associated coiled-coil forming kinage 2; Rho-associated coiled-coil forming kinase 2; Rho-associated protein kinase 2; Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase II; RhoA - binding serine/threosine kinase alpha (ROK - alpha); RhoA-binding kinase 2; ROCK II; ROCK-II; rockii; ROKalpha
Gene Aliases: B230113H15Rik; KIAA0619; mKIAA0619; Rho-kinase; ROCK-II; ROCK2; Rock2m; ROK; ROKalpha
UniProt ID: (Human) O75116, (Rat) Q62868, (Mouse) P70336
Entrez Gene ID: (Human) 9475, (Rat) 25537, (Mouse) 19878
protein serine/threonine kinase activity
structural molecule activity
protein binding
ATP binding
Rho GTPase binding
poly(A) RNA binding
metal ion binding
Rho-dependent protein serine/threonine kinase activity
kinase activity
nucleotide binding
protein kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
neural tube closure
protein phosphorylation
smooth muscle contraction
Rho protein signal transduction
extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of centrosome duplication
negative regulation of angiogenesis
actin cytoskeleton organization
chromosome condensation
regulation of actin cytoskeleton organization
regulation of circadian rhythm
regulation of keratinocyte differentiation
rhythmic process
dendrite morphogenesis
centrosome duplication
phosphorylation
intracellular signal transduction
cytokinesis
positive regulation of protein phosphorylation
I-kappaB kinase/NF-kappaB signaling
positive regulation of endothelial cell migration
positive regulation of gene expression
regulation of cell adhesion
cortical actin cytoskeleton organization
negative regulation of myosin-light-chain-phosphatase activity
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
regulation of stress fiber assembly
regulation of focal adhesion assembly
cellular response to testosterone stimulus
establishment of protein localization to plasma membrane
regulation of establishment of endothelial barrier
negative regulation of bicellular tight junction assembly
regulation of establishment of cell polarity
regulation of cell motility
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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