Proteintech

ROCK2(C-term) Polyclonal Antibody

ROCK2(C-term) Antibody in Immunocytochemistry (ICC/IF)

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ROCK2(C-term) Antibody (20248-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using ROCK2 antibody 20248-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

ROCK2(C-term) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

ROCK2(C-term) Antibody in Western Blot (WB)

Product Image Gallery

Product Details

20248-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to ROCK2.

Target Information

ROCK2, the predominant ROCK isoform in skeletal muscle, is an important regulator downstream of Rho GTPases. ROCK2 regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ROCK2 interacts with p22phox to phosphorylate p47phox and to control NADPH oxidase activation in human monocytes.

Proceedings of the National Academy of Sciences of the United States of America

Tlili A,Pintard C,Hurtado-Nedelec M,Liu D,Marzaioli V,Thieblemont N,Dang PM,El-Benna J

Tue Jan 17 00:00:00 UTC 2023

Stigmasterol protects human brain microvessel endothelial cells against ischemia-reperfusion injury through suppressing EPHA2 phosphorylation.

Chinese journal of natural medicines

Li S,Xu F,Yu L,Yu Q,Yu N,Fu J

Wed Feb 01 00:00:00 UTC 2023

Acetyl-L-carnitine improves erectile function in bilateral cavernous nerve injury rats via promoting cavernous nerve regeneration.

Andrology

Wang J,Song J,Song G,Feng Y,Pan J,Yang X,Xin Z,Hu P,Sun T,Liu K,Xu W,Wang T,Wang S,Liu J,Ruan Y

Fri Jul 01 00:00:00 UTC 2022

The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.

Cell proliferation

Ke W,Wang B,Hua W,Song Y,Lu S,Luo R,Li G,Wang K,Liao Z,Xiang Q,Li S,Wu X,Zhang Y,Yang C

Mon Feb 01 00:00:00 UTC 2021

The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.

Cell proliferation

Ke W,Wang B,Hua W,Song Y,Lu S,Luo R,Li G,Wang K,Liao Z,Xiang Q,Li S,Wu X,Zhang Y,Yang C

Mon Feb 01 00:00:00 UTC 2021

Suppressing the Na⁺/H⁺ exchanger 1: a new sight to treat depression.

Cell death & disease

Deng X,Ji Z,Xu B,Guo L,Xu L,Qin T,Feng L,Ma Z,Fu Q,Qu R,Quo Q,Ma S

Wed May 08 00:00:00 UTC 2019

Suppressing the Na⁺/H⁺ exchanger 1: a new sight to treat depression.

Cell death & disease

Deng X,Ji Z,Xu B,Guo L,Xu L,Qin T,Feng L,Ma Z,Fu Q,Qu R,Quo Q,Ma S

Wed May 08 00:00:00 UTC 2019

Modulation of LPA1 receptor-mediated neuronal apoptosis by Saikosaponin-d: A target involved in depression.

Neuropharmacology

Xu L,Su J,Guo L,Wang S,Deng X,Ma S

Sun Sep 01 00:00:00 UTC 2019

Activation of leukocyte immunoglobulin-like receptor B2 signaling pathway in cortical lesions of pediatric patients with focal cortical dysplasia type IIb and tuberous sclerosis complex.

Brain & development

Yue J,Zhang C,Shi X,Wei Y,Liu L,Liu S,Yang H

Fri Nov 01 00:00:00 UTC 2019

Activation of leukocyte immunoglobulin-like receptor B2 signaling pathway in cortical lesions of pediatric patients with focal cortical dysplasia type IIb and tuberous sclerosis complex.

Brain & development

Yue J,Zhang C,Shi X,Wei Y,Liu L,Liu S,Yang H

Fri Nov 01 00:00:00 UTC 2019

ROCK isoforms differentially modulate cancer cell motility by mechanosensing the substrate stiffness.

Acta biomaterialia

Peng Y,Chen Z,Chen Y,Li S,Jiang Y,Yang H,Wu C,You F,Zheng C,Zhu J,Tan Y,Qin X,Liu Y

Mon Apr 01 00:00:00 UTC 2019

ROCK isoforms differentially modulate cancer cell motility by mechanosensing the substrate stiffness.

Acta biomaterialia

Peng Y,Chen Z,Chen Y,Li S,Jiang Y,Yang H,Wu C,You F,Zheng C,Zhu J,Tan Y,Qin X,Liu Y

Mon Apr 01 00:00:00 UTC 2019

Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.

Biomaterials

Song H,Guo T,Zhao Z,Wei Y,Luo H,Weng W,Zhang R,Zhong M,Chen C,Su J,Shen W

Sat Sep 01 00:00:00 UTC 2018

Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.

Biomaterials

Song H,Guo T,Zhao Z,Wei Y,Luo H,Weng W,Zhang R,Zhong M,Chen C,Su J,Shen W

Sat Sep 01 00:00:00 UTC 2018

MiR-455-3p suppresses renal fibrosis through repression of ROCK2 expression in diabetic nephropathy.

Biochemical and biophysical research communications

Wu J,Liu J,Ding Y,Zhu M,Lu K,Zhou J,Xie X,Xu Y,Shen X,Chen Y,Shao X,Zhu C

Wed Sep 05 00:00:00 UTC 2018

MiR-455-3p suppresses renal fibrosis through repression of ROCK2 expression in diabetic nephropathy.

Biochemical and biophysical research communications

Wu J,Liu J,Ding Y,Zhu M,Lu K,Zhou J,Xie X,Xu Y,Shen X,Chen Y,Shao X,Zhu C

Wed Sep 05 00:00:00 UTC 2018

Effects of chemerin/CMKLR1 in obesity-induced hypertension and potential mechanism.

American journal of translational research

Weng C,Shen Z,Li X,Jiang W,Peng L,Yuan H,Yang K,Wang J

Fri Apr 08 00:00:00 UTC 2022

Effects of chemerin/CMKLR1 in obesity-induced hypertension and potential mechanism.

American journal of translational research

Weng C,Shen Z,Li X,Jiang W,Peng L,Yuan H,Yang K,Wang J

Fri Apr 08 00:00:00 UTC 2022

Effects of chemerin/CMKLR1 in obesity-induced hypertension and potential mechanism.

American journal of translational research

Weng C,Shen Z,Li X,Jiang W,Peng L,Yuan H,Yang K,Wang J

Fri Apr 08 00:00:00 UTC 2022

Effects of chemerin/CMKLR1 in obesity-induced hypertension and potential mechanism.

American journal of translational research

Weng C,Shen Z,Li X,Jiang W,Peng L,Yuan H,Yang K,Wang J

Fri Apr 08 00:00:00 UTC 2022

Lycopene Ameliorates Transplant Arteriosclerosis in Vascular Allograft Transplantation by Regulating the NO/cGMP Pathways and Rho-Associated Kinases Expression.

Oxidative medicine and cellular longevity

He Y,Xia P,Jin H,Zhang Y,Chen B,Xu Z

Mon Mar 13 00:00:00 UTC 2017

Lycopene Ameliorates Transplant Arteriosclerosis in Vascular Allograft Transplantation by Regulating the NO/cGMP Pathways and Rho-Associated Kinases Expression.

Oxidative medicine and cellular longevity

He Y,Xia P,Jin H,Zhang Y,Chen B,Xu Z

Mon Mar 13 00:00:00 UTC 2017

Activation of LILRB2 signal pathway in temporal lobe epilepsy patients and in a pilocarpine induced epilepsy model.

Experimental neurology