Product References
Dietary tryptophan deficiency promotes gut RORγt+ Treg cells at the expense of Gata3+ Treg cells and alters commensal microbiota metabolism.
Cell reports
Rankin LC,Kaiser KA,de Los Santos-Alexis K,Park H,Uhlemann AC,Gray DHD,Arpaia N
12-6988-82 was used in Flow Cytometry to investigate how perturbations influence the immune-microbiome interface.
Tue Mar 28 00:00:00 UTC 2023
Natural γδT17 cell development and functional acquisition is governed by the mTORC2-c-Maf-controlled mitochondrial fission pathway.
iScience
Wang Y,Qin H,Cai Y,Chen X,Li H,Montoya-Durango DE,Ding C,Hu X,Chariker JH,Sarojini H,Chien S,Rouchka EC,Zhang HG,Zheng J,Qiu F,Yan J
12-6988-82 was used in Flow cytometry/Cell sorting to provide an in-depth insight into the intrinsic link between the mitochondrial OXPHOS pathway and γδT17 thymic programming and functional acquisition.
Fri May 19 00:00:00 UTC 2023
The eIF4EBP-eIF4E axis regulates CD4+ T cell differentiation through modulation of T cell activation and metabolism.
iScience
Istomine R,Al-Aubodah TA,Alvarez F,Smith JA,Wagner C,Piccirillo CA
12-6988-82 was used in Flow Cytometry to examine how altered eIF4E activity affected T cell function using mice lacking eIF4E-binding proteins (BP-/-).
Fri May 19 00:00:00 UTC 2023
Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy.
Journal for immunotherapy of cancer
van Elsas MJ,Labrie C,Etzerodt A,Charoentong P,van Stigt Thans JJC,Van Hall T,van der Burg SH
12-6988-82 was used in Flow Cytometry to identify a small but discernible CD163hi macrophage population, with high expression of several tumor-promoting macrophage markers and a functional anti-inflammatory transcriptome profile, but not other macrophages, to be responsible.
Wed Mar 01 00:00:00 UTC 2023
MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function.
Immunity
Sugiura A,Andrejeva G,Voss K,Heintzman DR,Xu X,Madden MZ,Ye X,Beier KL,Chowdhury NU,Wolf MM,Young AC,Greenwood DL,Sewell AE,Shahi SK,Freedman SN,Cameron AM,Foerch P,Bourne T,Garcia-Canaveras JC,Karijolich J,Newcomb DC,Mangalam AK,Rabinowitz JD,Rathmell JC
12-6988-82 was used in Flow cytometry/Cell sorting to show that MTHFD2 is a metabolic checkpoint to integrate purine metabolism with pathogenic effector cell signaling and is a potential therapeutic target within 1C metabolism pathways.
Tue Jan 11 00:00:00 UTC 2022
Whole-genome profiling of DNA methylation and hydroxymethylation identifies distinct regulatory programs among innate lymphocytes.
Nature immunology
Peng V,Xing X,Bando JK,Trsan T,Di Luccia B,Collins PL,Li D,Wang WL,Lee HJ,Oltz EM,Wang T,Colonna M
12-6988-82 was used in Flow cytometry/Cell sorting to provide a powerful resource for studying innate lymphocyte epigenetic regulation and decode the regulatory logic governing their identity.
Fri Apr 01 00:00:00 UTC 2022
MBL Binding with AhR Controls Th17 Immunity in Silicosis-Associated Lung Inflammation and Fibrosis.
Journal of inflammation research
Liu Y,Zhao N,Xu Q,Deng F,Wang P,Dong L,Lu X,Xia L,Wang M,Chen Z,Zhou J,Zuo D
12-6988-82 was used in Flow cytometry/Cell sorting to suggest that MBL limited the Th17 immunity via controlling the AhR/STAT3 pathway, thus providing new insight into silicosis and other inflammatory diseases in patients with MBL deficiency.
Fri Aug 05 00:00:00 UTC 2022
Candida tropicalis Infection Modulates the Gut Microbiome and Confers Enhanced Susceptibility to Colitis in Mice.
Cellular and molecular gastroenterology and hepatology
Di Martino L,De Salvo C,Buela KA,Hager C,Ghannoum M,Osme A,Buttò L,Bamias G,Pizarro TT,Cominelli F
12-6988-82 was used in Flow Cytometry to determine the effects and mechanisms of action of Candida tropicalis on intestinal inflammation and injury in mouse models.
Mon Apr 04 00:00:00 UTC 2022
GM-CSF-activated human dendritic cells promote type 1 T follicular helper cell polarization in a CD40-dependent manner.
Journal of cell science
Korniotis S,Saichi M,Trichot C,Hoffmann C,Amblard E,Viguier A,Grondin S,Noel F,Mattoo H,Soumelis V
12-6988-82 was used in Flow cytometry/Cell sorting to report that human blood CD1c+ dendritic cells activated by GM-CSF (also known as CSF2) drive the differentiation of naive CD4+ T cells into Tfh1 cells.
Tue Nov 01 00:00:00 UTC 2022
Dysregulated Peripheral Invariant Natural Killer T Cells in Plaque Psoriasis Patients.
Frontiers in cell and developmental biology
Hu Y,Chen Y,Chen Z,Zhang X,Guo C,Yu Z,Xu P,Sun L,Zhou X,Gong Y,Yu Q,Shi Y
12-6988-82 was used in Flow cytometry/Cell sorting to explore the expression of iNKT cells in psoriasis patients and the effect of secukinumab on them.
Wed Feb 23 00:00:00 UTC 2022
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.
Frontiers in immunology
Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F
12-6988-82 was used in Flow cytometry/Cell sorting to suggest that graded RhoA expression in Treg cells distinguishes tumor immunity from autoimmunity and that rational targeting of RhoA in Treg cells may trigger anti-tumor T cell immunity without causing autoimmune responses.
Tue Jan 11 00:00:00 UTC 2022
Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis.
Journal for immunotherapy of cancer
Yang C,Wang Z,Li L,Zhang Z,Jin X,Wu P,Sun S,Pan J,Su K,Jia F,Zhang L,Wang H,Yu X,Shao X,Wang K,Qiu F,Yan J,Huang J
12-6988-82 was used in Flow Cytometry to investigate the existence and biological function of a rarely delved subset of neutrophils, named as tumor-associated aged neutrophils (Naged, CXCR4+CD62Llow), involved in premetastatic niche formation during breast cancer metastasis.
Fri Oct 01 00:00:00 UTC 2021
Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis.
Journal for immunotherapy of cancer
Yang C,Wang Z,Li L,Zhang Z,Jin X,Wu P,Sun S,Pan J,Su K,Jia F,Zhang L,Wang H,Yu X,Shao X,Wang K,Qiu F,Yan J,Huang J
12-6988-82 was used in Flow Cytometry to investigate the existence and biological function of a rarely delved subset of neutrophils, named as tumor-associated aged neutrophils (Naged, CXCR4+CD62Llow), involved in premetastatic niche formation during breast cancer metastasis.
Fri Oct 01 00:00:00 UTC 2021
Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism.
Nature communications
Fu Z,Dean JW,Xiong L,Dougherty MW,Oliff KN,Chen ZE,Jobin C,Garrett TJ,Zhou L
12-6988-82 was used in Flow Cytometry to show that IL-22, a cytokine produced by RORγt+ lymphocytes inhibits IL-13-induced tuft cell differentiation in vitro, and suppresses the tuft cell-type 2 immune circuit and small intestine lengthening in vivo, highlighting its key role in gut tissue remodeling.
Thu Jul 22 00:00:00 UTC 2021
Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense.
Cell
Lai NY,Musser MA,Pinho-Ribeiro FA,Baral P,Jacobson A,Ma P,Potts DE,Chen Z,Paik D,Soualhi S,Yan Y,Misra A,Goldstein K,Lagomarsino VN,Nordstrom A,Sivanathan KN,Wallrapp A,Kuchroo VK,Nowarski R,Starnbach MN,Shi H,Surana NK,An D,Wu C,Huh JR,Rao M,Chiu IM
12-6988-82 was used in Flow Cytometry to reveal a major role for nociceptor neurons in sensing and defending against enteric pathogens.
Thu Jan 09 00:00:00 UTC 2020
Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.
Immunity
DiToro D,Harbour SN,Bando JK,Benavides G,Witte S,Laufer VA,Moseley C,Singer JR,Frey B,Turner H,Bruning J,Darley-Usmar V,Gao M,Conover C,Hatton RD,Frank S,Colonna M,Weaver CT
12-6988 was used in Flow cytometry/Cell sorting to show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system.
Tue Apr 14 00:00:00 UTC 2020
T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity.
Nature immunology
Jain A,Irizarry-Caro RA,McDaniel MM,Chawla AS,Carroll KR,Overcast GR,Philip NH,Oberst A,Chervonsky AV,Katz JD,Pasare C
12-6988 was used in Flow cytometry/Cell sorting to describe an inflammasome-independent pathway of IL-1β production that was triggered upon cognate interactions between effector CD4+ T cells and mononuclear phagocytes.
Wed Jan 01 00:00:00 UTC 2020
ILC2s are the predominant source of intestinal ILC-derived IL-10.
The Journal of experimental medicine
Bando JK,Gilfillan S,Di Luccia B,Fachi JL,Sécca C,Cella M,Colonna M
12-6988 was used in Flow cytometry/Cell sorting to report the absence of an intestinal regulatory ILC population distinct from group 1 ILCs (ILC1s), ILC2s, and ILC3s in (1) mice bred in our animal facility; (2) mice from The Jackson Laboratory, Taconic Biosciences, and Charles River Laboratories; and (3) mice subjected to intestinal inflammation.
Mon Feb 03 00:00:00 UTC 2020
Actin-Binding Protein Cortactin Promotes Pathogenesis of Experimental Autoimmune Encephalomyelitis by Supporting Leukocyte Infiltration into the Central Nervous System.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Samus M,Li YT,Sorokin L,Rottner K,Vestweber D
12-6988-82 was used in Immunohistochemistry to study the role of cortactin in experimental autoimmune encephalomyelitis through the use of cortactin gene-inactivated male and female mice.
Wed Feb 12 00:00:00 UTC 2020
Human Fc Receptor-like 3 Inhibits Regulatory T Cell Function and Binds Secretory IgA.
Cell reports
Agarwal S,Kraus Z,Dement-Brown J,Alabi O,Starost K,Tolnay M
12-6988 was used in Flow cytometry/Cell sorting to study the functional regulation of T cells by human Fc receptor-like 3.
Tue Feb 04 00:00:00 UTC 2020
Th2 Biased Immunity With Altered B Cell Profiles in Circulation of Patients With Sporotrichosis Caused by Sporothrix globosa.
Frontiers in immunology
Zu J,Yao L,Song Y,Cui Y,Guan M,Chen R,Zhen Y,Li S
12-6988 was used in Flow cytometry/Cell sorting to shed light on the potential involvement of peripheral T and B cell immunity against this mycotic infection.
Mon May 31 00:00:00 UTC 2021
Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells.
Cell reports
Morelli AE,Sumpter TL,Rojas-Canales DM,Bandyopadhyay M,Chen Z,Tkacheva O,Shufesky WJ,Wallace CT,Watkins SC,Berger A,Paige CJ,Falo LD,Larregina AT
12-6988 was used in Flow cytometry/Cell sorting to demonstrate an effect of the NK1R in T cells that is relevant for immunotherapies based on pro-inflammatory neuropeptides and its receptors.
Tue Mar 10 00:00:00 UTC 2020
IL-6, NLR, and SII Markers and Their Relation with Alterations in CD8+ T-Lymphocyte Subpopulations in Patients Treated for Lung Adenocarcinoma.
Biology
Islas-Vazquez L,Aguilar-Cazares D,Galicia-Velasco M,Rumbo-Nava U,Meneses-Flores M,Luna-Rivero C,Lopez-Gonzalez JS
12-6988 was used in Flow cytometry/Cell sorting to study IL-6 production by tumor cells assessed in a cohort of patients with lung adenocarcinoma treated with conventional therapy.
Thu Nov 05 00:00:00 UTC 2020
Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells.
Cell reports
Yang YH,Istomine R,Alvarez F,Al-Aubodah TA,Shi XQ,Takano T,Thornton AM,Shevach EM,Zhang J,Piccirillo CA
12-6988-82 was used in Flow Cytometry to show that high salt (HS) drives thymic Treg cells to adopt a T helper type 17 (Th17)-like phenotype and enhances generation of Th17-like induced Treg cells in a SGK1-dependent manner, all the while maintaining suppressive function.
Tue Feb 04 00:00:00 UTC 2020
Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities.
Nature communications
Cho SX,Rudloff I,Lao JC,Pang MA,Goldberg R,Bui CB,McLean CA,Stock M,Klassert TE,Slevogt H,Mangan NE,Cheng W,Fischer D,Gfroerer S,Sandhu MK,Ngo D,Bujotzek A,Lariviere L,Schumacher F,Tiefenthaler G,Beker F,Collins C,Kamlin COF,König K,Malhotra A,Tan K,Theda C,Veldman A,Ellisdon AM,Whisstock JC,Berger PJ,Nold-Petry CA,Nold MF
12-6988 was used in Flow cytometry/Cell sorting to implicate type 3 cytokines, TLRs and IL-37 as potential targets for novel Necrotizing enterocolitis therapies.
Fri Nov 13 00:00:00 UTC 2020
Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation.
Science signaling
Jun JE,Kulhanek KR,Chen H,Chakraborty A,Roose JP
12-6988 was used in Flow cytometry/Cell sorting to investigate how both classical and alternative p38 pathways contribute to T cell activation and therefore the immune balance.
Tue Jul 23 00:00:00 UTC 2019
Frontline Science: Abnormalities in the gut mucosa of non-obese diabetic mice precede the onset of type 1 diabetes.
Journal of leukocyte biology
Miranda MCG,Oliveira RP,Torres L,Aguiar SLF,Pinheiro-Rosa N,Lemos L,Guimarães MA,Reis D,Silveira T,Ferreira Ê,Moreira TG,Cara DC,Maioli TU,Kelsall BL,Carlos D,Faria AMC
12-6988-82 was used in Flow cytometry/Cell sorting to show that disorders in the intestinal mucosa of NOD mice can potentially interfere with the development of T1D due the close relationship between the gut and the pancreas.
Sun Sep 01 00:00:00 UTC 2019
Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis.
Cell reports
Pyaram K,Kumar A,Kim YH,Noel S,Reddy SP,Rabb H,Chang CH
12-6988 was used in Flow cytometry/Cell sorting to report that T cellspecific deletion of Keap1 results in defective development and reduced numbers of invariant natural killer T (NKT) cells in the thymus and the peripheral organs in a cell-intrinsic manner.
Tue Apr 16 00:00:00 UTC 2019
KS23, a novel peptide derived from adiponectin, inhibits retinal inflammation and downregulates the proportions of Th1 and Th17 cells during experimental autoimmune uveitis.
Journal of neuroinflammation
Niu T,Cheng L,Wang H,Zhu S,Yang X,Liu K,Jin H,Xu X
12-6988 was used in Flow cytometry/Cell sorting to evaluate the preventive effect of KS23 in experimental autoimmune uveitis (EAU).
Sat Dec 28 00:00:00 UTC 2019
Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis.
Immunity
Hirota K,Hashimoto M,Ito Y,Matsuura M,Ito H,Tanaka M,Watanabe H,Kondoh G,Tanaka A,Yasuda K,Kopf M,Potocnik AJ,Stockinger B,Sakaguchi N,Sakaguchi S
12-6988 was used in Flow cytometry/Cell sorting to study the signalling pathway responsible for mediating the stimulation of fibroblast-like synoviocytes by arthritogenic Th17 cells.
Tue Jun 19 00:00:00 UTC 2018
Interleukin-17-Producing γδ T Cells Originate from SOX13+ Progenitors that Are Independent of γδTCR Signaling.
Immunity
Spidale NA,Sylvia K,Narayan K,Miu B,Frascoli M,Melichar HJ,Zhihao W,Kisielow J,Palin A,Serwold T,Love P,Kobayashi M,Yoshimoto M,Jain N,Kang J
12-6988-82 was used in Flow Cytometry to generate reporter mice for the Tγδ17 lineage-defining transcription factor SOX13 and identify fetal-origin, intrathymic Sox13+ progenitors.
Tue Nov 20 00:00:00 UTC 2018
Human CD40 ligand-expressing type 3 innate lymphoid cells induce IL-10-producing immature transitional regulatory B cells.
The Journal of allergy and clinical immunology
Komlósi ZI,Kovács N,van de Veen W,Kirsch AI,Fahrner HB,Wawrzyniak M,Rebane A,Stanic B,Palomares O,Rückert B,Menz G,Akdis M,Losonczy G,Akdis CA
12-6988 was used in Flow cytometry/Cell sorting to investigate the ILC3-B-cell interaction that probably takes place in human tonsils.
Sun Jul 01 00:00:00 UTC 2018
Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma.
Nature communications
Lorentsen KJ,Cho JJ,Luo X,Zuniga AN,Urban JF,Zhou L,Gharaibeh R,Jobin C,Kladde MP,Avram D
12-6988 was used in Flow cytometry/Cell sorting to establish novel roles for Bcl11b in the regulatory loop that licenses Th2 program in vivo.
Thu Apr 26 00:00:00 UTC 2018
Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells.
Cell reports
Ogawa C,Bankoti R,Nguyen T,Hassanzadeh-Kiabi N,Nadeau S,Porritt RA,Couse M,Fan X,Dhall D,Eberl G,Ohnmacht C,Martins GA
12-6988-82 was used in Flow Cytometry to study the role of Blimp-1 as a crucial regulator of the Foxp3+RORγt+ regulatory T cell subset.
Tue Oct 02 00:00:00 UTC 2018
Lactobacillus acidophilus inhibits bone loss and increases bone heterogeneity in osteoporotic mice via modulating Treg-Th17 cell balance.
Bone reports
Dar HY,Shukla P,Mishra PK,Anupam R,Mondal RK,Tomar GB,Sharma V,Srivastava RK
12-6988 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic potential of Lactobacillus acidophilus as an osteo-protective agent in enhancing bone health in postmenopausal osteoporosis.
Fri Jun 01 00:00:00 UTC 2018
The Combination Therapy of Dietary Galacto-Oligosaccharides With Budesonide Reduces Pulmonary Th2 Driving Mediators and Mast Cell Degranulation in a Murine Model of House Dust Mite Induced Asthma.
Frontiers in immunology
Verheijden KAT,Braber S,Leusink-Muis T,Jeurink PV,Thijssen S,Kraneveld AD,Garssen J,Folkerts G,Willemsen LEM
12-6988 was used in Flow cytometry/Cell sorting to compare the efficacy of budesonide or different doses of galacto-oligosaccharides alone or with a combination therapy of budesonide and galacto-oligosaccharides on house dust mite-allergic responses in mice.
Mon Sep 30 00:00:00 UTC 2019
Regulation of Th17 cells by P. UF1 against systemic Listeria monocytogenes infection.
Gut microbes
Colliou N,Ge Y,Gong M,Zadeh M,Li J,Alonzo F,Mohamadzadeh M
12-6988-82 was used in Flow Cytometry to demonstrate that P. UF1 not only robustly regulated protective Th17 and Th1 cells, but also sustained regulatory T cells (Treg cells) resulting in accelerated L. m clearance.
Wed Sep 05 00:00:00 UTC 2018
An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk.
Cell
Yissachar N,Zhou Y,Ung L,Lai NY,Mohan JF,Ehrlicher A,Weitz DA,Kasper DL,Chiu IM,Mathis D,Benoist C
12-6988 was used in Flow cytometry/Cell sorting to study the microbe-immune crosstalk in a microfabricated organ culture system of the mouse intestine.
Thu Mar 09 00:00:00 UTC 2017
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
Thu Sep 21 00:00:00 UTC 2017
Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.
Cell
Lim AI,Li Y,Lopez-Lastra S,Stadhouders R,Paul F,Casrouge A,Serafini N,Puel A,Bustamante J,Surace L,Masse-Ranson G,David E,Strick-Marchand H,Le Bourhis L,Cocchi R,Topazio D,Graziano P,Muscarella LA,Rogge L,Norel X,Sallenave JM,Allez M,Graf T,Hendriks RW,Casanova JL,Amit I,Yssel H,Di Santo JP
12-6988 was used in Flow cytometry/Cell sorting to identify circulating and tissue ILC precursors in humans that fail to express the transcription factors and cytokine outputs of mature ILCs but have these signature loci in an epigenetically poised configuration.
Thu Mar 09 00:00:00 UTC 2017
The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development.
Immunity
Miyazaki M,Miyazaki K,Chen K,Jin Y,Turner J,Moore AJ,Saito R,Yoshida K,Ogawa S,Rodewald HR,Lin YC,Kawamoto H,Murre C
12-6988 was used in Flow cytometry/Cell sorting to propose that the E-Id protein axis specifies innate and adaptive lymphoid cell fate.
Tue May 16 00:00:00 UTC 2017
Inducible and naturally occurring regulatory T cells enhance lung allergic responses through divergent transcriptional pathways.
The Journal of allergy and clinical immunology
Joetham A,Schedel M,O'Connor BP,Kim S,Takeda K,Abbott J,Gelfand EW
12-6988 was used in Flow cytometry/Cell sorting to study the differences between the pathways leading to enhancement of lung allergic responses by both transferred naturally occurring regulatory T and inducible regulatory T cells.
Sat Apr 01 00:00:00 UTC 2017
MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates.
Mucosal immunology
Greene JM,Dash P,Roy S,McMurtrey C,Awad W,Reed JS,Hammond KB,Abdulhaqq S,Wu HL,Burwitz BJ,Roth BF,Morrow DW,Ford JC,Xu G,Bae JY,Crank H,Legasse AW,Dang TH,Greenaway HY,Kurniawan M,Gold MC,Harriff MJ,Lewinsohn DA,Park BS,Axthelm MK,Stanton JJ,Hansen SG,Picker LJ,Venturi V,Hildebrand W,Thomas PG,Lewinsohn DM,Adams EJ,Sacha JB
12-6988 was used in Flow cytometry/Cell sorting to investigate the response of MR1 restricted mucosal-associated invariant T cells to mycobacterial vaccination and infection in nonhuman primates.
Mon May 01 00:00:00 UTC 2017
Huai Qi Huang corrects the balance of Th1/Th2 and Treg/Th17 in an ovalbumin-induced asthma mouse model.
Bioscience reports
Liang P,Peng S,Zhang M,Ma Y,Zhen X,Li H
12-6988 was used in Flow cytometry/Cell sorting to determine the immunoregulatory effects of Huai Qi Huang on regulatory and helper T cell balance in ovalbumin induced asthma.
Fri Dec 22 00:00:00 UTC 2017
CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis.
Nature communications
Barthels C,Ogrinc A,Steyer V,Meier S,Simon F,Wimmer M,Blutke A,Straub T,Zimber-Strobl U,Lutgens E,Marconi P,Ohnmacht C,Garzetti D,Stecher B,Brocker T
12698882 was used in flow cytometry to report a CD40-dependent mechanism capable of abrogating inducible T regulatory cell induction by dendritic cells
Thu Mar 09 00:00:00 UTC 2017
Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease.
Scientific reports
Minter MR,Hinterleitner R,Meisel M,Zhang C,Leone V,Zhang X,Oyler-Castrillo P,Zhang X,Musch MW,Shen X,Jabri B,Chang EB,Tanzi RE,Sisodia SS
12-6988 was used in Flow cytometry/Cell sorting to investigate how ABX-induced microbial diversity perturbations during post-natal stages of development coincide with altered host immunity mechanisms and amyloidosis in a murine model of AD.
Tue Sep 05 00:00:00 UTC 2017
Etanercept-Synthesising Mesenchymal Stem Cells Efficiently Ameliorate Collagen-Induced Arthritis.
Scientific reports
Park N,Rim YA,Jung H,Kim J,Yi H,Kim Y,Jang Y,Jung SM,Lee J,Kwok SK,Park SH,Ju JH
12-6988 was used in Flow cytometry/Cell sorting to develop a novel method to produce synthetic biological drugs from engineered MSCs, and investigate the anti-arthritic effect of these cells in a collagen-induced arthritis mouse model.
Fri Jan 13 00:00:00 UTC 2017
Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion.
JCI insight
Bowers JS,Nelson MH,Majchrzak K,Bailey SR,Rohrer B,Kaiser AD,Atkinson C,Gattinoni L,Paulos CM
12-6988 was used in Flow cytometry/Cell sorting to study the use of tumour-reactive Th17 cells as a cell therapy for cancer.
Thu Mar 09 00:00:00 UTC 2017
A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.
Nature communications
Johnston CJC,Smyth DJ,Kodali RB,White MPJ,Harcus Y,Filbey KJ,Hewitson JP,Hinck CS,Ivens A,Kemter AM,Kildemoes AO,Le Bihan T,Soares DC,Anderton SM,Brenn T,Wigmore SJ,Woodcock HV,Chambers RC,Hinck AP,McSorley HJ,Maizels RM
12-6988 was used in Flow cytometry/Cell sorting to indicate that through the helminth parasite has acquired a protein with cytokine-like function that is able to exploit an endogenous pathway of immunoregulation in the host.
Thu Nov 23 00:00:00 UTC 2017
Toll-like receptor 2 induced cytotoxic T-lymphocyte-associated protein 4 regulates Aspergillus-induced regulatory T-cells with pro-inflammatory characteristics.
Scientific reports
Raijmakers RPH,Sprenkeler EGG,Aleva FE,Jacobs CWM,Kanneganti TD,Joosten LAB,van de Veerdonk FL,Gresnigt MS
Wed Sep 13 00:00:00 UTC 2017
Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF-TNF-RII binding in rheumatoid arthritis.
The Journal of experimental medicine
Nguyen DX,Ehrenstein MR
12-6988 was used in Flow cytometry/Cell sorting to investigate whether TNF boosts of inhibits regulatory T cells (T reg cells), showing that anti-TNF drives regulatory T cell expansion by promoting membrane TNF-TNF-RII binding, in rheumatoid arthritis.
Mon Jun 27 00:00:00 UTC 2016
Heat-killed Staphylococcus aureus reduces atherosclerosis by inducing anti-inflammatory macrophages.
Journal of internal medicine
Frodermann V,van Duijn J,van Puijvelde GH,van Santbrink PJ,Lagraauw HM,de Vries MR,Quax PH,Bot I,Foks AC,de Jager SC,Kuiper J
12698882 was used in flow cytometry to test whether heat-killed Staphyloccocus aureus inhibits the development of atherosclerosis
Wed Jun 01 00:00:00 UTC 2016
Treatment with cyclophosphamide supported by various dendritic cell-based vaccines induces diversification in CD4⁺ T cell response against MC38 colon carcinoma.
International journal of oncology
Wojas-Turek J,Szczygieł A,Kicielińska J,Rossowska J,Piasecki E,Pajtasz-Piasecka E
12-6988 was used in Flow cytometry/Cell sorting to show that an application of cyclophosphamide supported by dendritic cell based vaccines affected differentiation of the activity of CD4+ T cell subpopulations accompanied by an alteration in CD8+ cell number.
Mon Feb 01 00:00:00 UTC 2016
Fetal CD103+ IL-17-Producing Group 3 Innate Lymphoid Cells Represent the Dominant Lymphocyte Subset in Human Amniotic Fluid.
Journal of immunology (Baltimore, Md. : 1950)
Marquardt N,Ivarsson MA,Sundström E,Åkesson E,Martini E,Eidsmo L,Mjösberg J,Friberg D,Kublickas M,Ek S,Tegerstedt G,Seiger Å,Westgren M,Michaëlsson J
12-6988 was used in Flow cytometry/Cell sorting to indicate that CD103+ ILC3s accumulate with gestation in the fetal intestine before egress to the amniotic fluid.
Sat Oct 15 00:00:00 UTC 2016
ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation.
eLife
Pearson C,Thornton EE,McKenzie B,Schaupp AL,Huskens N,Griseri T,West N,Tung S,Seddon BP,Uhlig HH,Powrie F
12-6988 was used in Immunofluorescence on frozen tissues to investigate how a small population of innate lymphoid cells (ILCs) has large effects on immune homeostasis, showing that ILC3s produce GM-CSF to orchestrate acute intestinal inflammation.
Mon Jan 18 00:00:00 UTC 2016
Activation of the Renin-Angiotensin System Promotes Colitis Development.
Scientific reports
Shi Y,Liu T,He L,Dougherty U,Chen L,Adhikari S,Alpert L,Zhou G,Liu W,Wang J,Deb DK,Hart J,Liu SQ,Kwon J,Pekow J,Rubin DT,Zhao Q,Bissonnette M,Li YC
12-6988 was used in Flow cytometry/Cell sorting to demonstrate that the renin-angiotensin II cascade promotes colitis by stimulating intestinal epithelial cell apoptosis and mucosal TH17 responses in a blood pressure-independent manner.
Wed Jun 08 00:00:00 UTC 2016
Regulatory T cells that co-express RORγt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer.
Oncoimmunology
Chellappa S,Hugenschmidt H,Hagness M,Line PD,Labori KJ,Wiedswang G,Taskén K,Aandahl EM
12-6988 was used in Flow cytometry/Cell sorting to investigate the phenotype and functional properties of regulatory T cells in patients with pancreatic ductal adenocarcinoma.
Fri Apr 01 00:00:00 UTC 2016
Characterization and Quantification of Innate Lymphoid Cell Subsets in Human Lung.
PloS one
De Grove KC,Provoost S,Verhamme FM,Bracke KR,Joos GF,Maes T,Brusselle GG
12-6988 was used in Flow cytometry/Cell sorting to study innate lymphoid cells in the human lung in healthy patients and those with chronic pulmonary disease.
Fri Jul 08 00:00:00 UTC 2016
IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease.
Nature communications
Tosiek MJ,Fiette L,El Daker S,Eberl G,Freitas AA
12-6988 was used in Flow cytometry/Cell sorting to demonstrate that impaired delivery of IL-15 to CD4+ T cells in the colon down-modulates Foxp3 expression and enhances RORγt expression.
Fri Mar 11 00:00:00 UTC 2016
IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
Nature immunology
Basu R,Whitley SK,Bhaumik S,Zindl CL,Schoeb TR,Benveniste EN,Pear WS,Hatton RD,Weaver CT
12-6988 was used in Flow cytometry/Cell sorting to assess the ability of IL-1 to override retinoic acid-mediated expression of the transcription factor Foxp3 and induce protective TH17 cell responses.
Sun Mar 01 00:00:00 UTC 2015
Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.
Oncogene
De Simone V,Franzè E,Ronchetti G,Colantoni A,Fantini MC,Di Fusco D,Sica GS,Sileri P,MacDonald TT,Pallone F,Monteleone G,Stolfi C
12-6988 was used in Flow cytometry/Cell sorting to explore cotargeting of STAT3 and NF-kB as a novel approach to combat colorectal cancers.
Wed Jul 01 00:00:00 UTC 2015
Reciprocal regulation of lymphoid tissue development in the large intestine by IL-25 and IL-23.
Mucosal immunology
Donaldson DS,Bradford BM,Artis D,Mabbott NA
12-6988 was used in Flow cytometry/Cell sorting to assess the relationship between microbiota in the colon and development of isolated lymphoid follicles.
Fri May 01 00:00:00 UTC 2015
The transduction pattern of IL-12-encoding lentiviral vectors shapes the immunological outcome.
European journal of immunology
Goyvaerts C,Broos K,Escors D,Heirman C,Raes G,De Baetselier P,Thielemans K,Breckpot K
12-6988-82 was used in Flow Cytometry to demonstrate that codelivery of IL-12 enhances the CD4(+) TH 1 profile irrespective of its delivery mode, while an increase in cytotoxic and therapeutic CD8(+) T cells was only induced upon VSV-G-LV injection.
Tue Dec 01 00:00:00 UTC 2015
Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Marquardt N,Béziat V,Nyström S,Hengst J,Ivarsson MA,Kekäläinen E,Johansson H,Mjösberg J,Westgren M,Lankisch TO,Wedemeyer H,Ellis EC,Ljunggren HG,Michaëlsson J,Björkström NK
12-6988 was used in Flow cytometry/Cell sorting to study the unique lineage of CD49a(+)DX5(-) NK cells, showing that they are readily detectable in the liver but not in hepatic venous or peripheral blood.
Sun Mar 15 00:00:00 UTC 2015
LAP TGF-Beta Subset of CD4(+)CD25(+)CD127(-) Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients.
BioMed research international
Islas-Vazquez L,Prado-Garcia H,Aguilar-Cazares D,Meneses-Flores M,Galicia-Velasco M,Romero-Garcia S,Camacho-Mendoza C,Lopez-Gonzalez JS
12-6988 was used in Flow cytometry/Cell sorting to show that there are higher levels of proinflammatory (IL-2 and IL-6) and anti-inflammatory (IL-4 and IL-10) cytokines in lung adenocarcinoma patients compared with smoking subjects.
Wed Aug 31 00:00:00 UTC 2016
Mesenchymal Stem Cells Reduce Murine Atherosclerosis Development.
Scientific reports
Frodermann V,van Duijn J,van Pel M,van Santbrink PJ,Bot I,Kuiper J,de Jager SC
12-6988 was used in Flow cytometry/Cell sorting to study how MSC treatment affects not only inflammatory responses but also significantly reduces dyslipidaemia in mice.
Thu Oct 22 00:00:00 UTC 2015
Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells.
PLoS neglected tropical diseases
Katawa G,Layland LE,Debrah AY,von Horn C,Batsa L,Kwarteng A,Arriens S,W Taylor D,Specht S,Hoerauf A,Adjobimey T
12-6988 was used in Flow cytometry/Cell sorting to provide initial evidence that elevated frequencies of Th17 and Th2 cells form part of the immune network instigating the development of severe onchocerciasis.
Thu Jan 01 00:00:00 UTC 2015
Central Role of Core Binding Factor β2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse.
PloS one
Nagatake T,Fukuyama S,Sato S,Okura H,Tachibana M,Taniuchi I,Ito K,Shimojou M,Matsumoto N,Suzuki H,Kunisawa J,Kiyono H
12-6988 was used in Immunohistochemistry to demonstrate that Cbfβ2 is a central regulator of the mucosa-associated lymphoid tissue developmental program.
Thu Apr 21 00:00:00 UTC 2016
NCR(+)ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures.
Nature communications
Carrega P,Loiacono F,Di Carlo E,Scaramuccia A,Mora M,Conte R,Benelli R,Spaggiari GM,Cantoni C,Campana S,Bonaccorsi I,Morandi B,Truini M,Mingari MC,Moretta L,Ferlazzo G
12-6988 was used in Flow cytometry/Cell sorting to investigate the role of the NCR(+) ILC-3 in non-small cell lung cancer.
Wed Sep 23 00:00:00 UTC 2015
Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients.
The Journal of investigative dermatology
Teunissen MBM,Munneke JM,Bernink JH,Spuls PI,Res PCM,Te Velde A,Cheuk S,Brouwer MWD,Menting SP,Eidsmo L,Spits H,Hazenberg MD,Mjösberg J
12-6988 was used in Flow cytometry/Cell sorting to suggest that NCR(+) group three innate lymphoid cells may participate in psoriasis pathology.
Mon Sep 01 00:00:00 UTC 2014
An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
White AJ,Jenkinson WE,Cowan JE,Parnell SM,Bacon A,Jones ND,Jenkinson EJ,Anderson G
12-6988 was used in Flow cytometry/Cell sorting to investigate whether thymus microenvironments are required in iNKT cell development, showing that medullary thymic epithelial cells are essential for intrathymic development of iNKT cells.
Sat Mar 15 00:00:00 UTC 2014
Self in vivo production of a synthetic biological drug CTLA4Ig using a minicircle vector.
Scientific reports
Rim YA,Yi H,Kim Y,Park N,Jung H,Kim J,Jung SM,Park SH,Ju JH
12-6988 was used in Flow cytometry/Cell sorting to investigate the effect of in vivo CTLA4Ig expression using a minicircle vector on rheumatoid arthritis.
Thu Nov 06 00:00:00 UTC 2014
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
Nature immunology
Satpathy AT,Briseño CG,Lee JS,Ng D,Manieri NA,Kc W,Wu X,Thomas SR,Lee WL,Turkoz M,McDonald KG,Meredith MM,Song C,Guidos CJ,Newberry RD,Ouyang W,Murphy TL,Stappenbeck TS,Gommerman JL,Nussenzweig MC,Colonna M,Kopan R,Murphy KM
12-6988 was used in Flow cytometry/Cell sorting to elucidate the cellular source of essential IL-23 production required for the mucosal response to attaching-and-effacing bacterial infection.
Sun Sep 01 00:00:00 UTC 2013
Unexpected heterogeneity of multifunctional T cells in response to superantigen stimulation in humans.
Clinical immunology (Orlando, Fla.)
McArthur MA,Sztein MB
12-6988 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which Staphylococcal enterotoxin B and other superantigens cause toxic shock syndrome.
Fri Feb 01 00:00:00 UTC 2013
A novel data mining system points out hidden relationships between immunological markers in multiple sclerosis.
Immunity & ageing : I & A
Gironi M,Saresella M,Rovaris M,Vaghi M,Nemni R,Clerici M,Grossi E
12-6988 was used in Flow cytometry/Cell sorting to analyse biomarkers in patients affected with multiple sclerosis at different stages of the disease.
Thu Jan 10 00:00:00 UTC 2013
Th17-cell plasticity in Helicobacter hepaticus-induced intestinal inflammation.
Mucosal immunology
Morrison PJ,Bending D,Fouser LA,Wright JF,Stockinger B,Cooke A,Kullberg MC
12-6988 was used in Flow cytometry/Cell sorting to uncover the immunoinflammatory contribution of Th1 and Th17 T cell subsets during murine Helicobacter hepaticus-induced typhlocolitis.
Fri Nov 01 00:00:00 UTC 2013
CagA-dependent downregulation of B7-H2 expression on gastric mucosa and inhibition of Th17 responses during Helicobacter pylori infection.
Journal of immunology (Baltimore, Md. : 1950)
Lina TT,Pinchuk IV,House J,Yamaoka Y,Graham DY,Beswick EJ,Reyes VE
12-6988 was used in Flow cytometry/Cell sorting to investigate the impact of H.pylori CagA on the modulation of the expression of the T cell costimulator B7-H2 by gastric epithelial cells.
Tue Oct 01 00:00:00 UTC 2013
Helicobacter pylori infection in a pig model is dominated by Th1 and cytotoxic CD8+ T cell responses.
Infection and immunity
Kronsteiner B,Bassaganya-Riera J,Philipson C,Viladomiu M,Carbo A,Pedragosa M,Vento S,Hontecillas R
12-6988 was used in Flow cytometry/Cell sorting to investigate the phenotypic and functional changes in PMBC populations during Helicobacter pylori infection, showing that infection is dominated by Th1 and cytotoxic CD8+ T cell responses.
Tue Oct 01 00:00:00 UTC 2013
Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development.
The Journal of biological chemistry
Wong LY,Hatfield JK,Brown MA
12-6988 was used in Flow cytometry/Cell sorting to investigate the factors that influence the development of Th17 cells, showing that lineage gene expression is set by Ikaros.
Fri Dec 06 00:00:00 UTC 2013
Stromal cells induce Th17 during Helicobacter pylori infection and in the gastric tumor microenvironment.
PloS one
Pinchuk IV,Morris KT,Nofchissey RA,Earley RB,Wu JY,Ma TY,Beswick EJ
12-6988 was used in Flow cytometry/Cell sorting to investigate the role of Th17 cells are CD4(+) T cells during Helicobacter pylori-associated gastric carcinogenesis.
Mon Jul 08 00:00:00 UTC 2013
Distinct requirements for T-bet in gut innate lymphoid cells.
The Journal of experimental medicine
Sciumé G,Hirahara K,Takahashi H,Laurence A,Villarino AV,Singleton KL,Spencer SP,Wilhelm C,Poholek AC,Vahedi G,Kanno Y,Belkaid Y,O'Shea JJ
12-6988 was used in Flow cytometry/Cell sorting to determine whether the transcription factor T-bet can control the development and function of a distinct interleukin-22-producing innate lymphoid cell subset.
Mon Dec 17 00:00:00 UTC 2012
IL-17 and IFN-γ expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease.
Journal of leukocyte biology
Jurado JO,Pasquinelli V,Alvarez IB,Peña D,Rovetta AI,Tateosian NL,Romeo HE,Musella RM,Palmero D,Chuluyán HE,García VE
12-6988 was used in Flow cytometry/Cell sorting to investigate the induction and regulation of IFN-γ and IL-17 during active human Mycobacterium tuberculosis infection.
Fri Jun 01 00:00:00 UTC 2012
CD5-dependent CK2 activation pathway regulates threshold for T cell anergy.
Journal of immunology (Baltimore, Md. : 1950)
Sestero CM,McGuire DJ,De Sarno P,Brantley EC,Soldevila G,Axtell RC,Raman C
12-6988 was used in Flow cytometry/Cell sorting to determine the physiological significance of CD5-dependent casein kinase 2 activation in T cells.
Sat Sep 15 00:00:00 UTC 2012
CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential.
Journal of immunology (Baltimore, Md. : 1950)
Radulovic K,Manta C,Rossini V,Holzmann K,Kestler HA,Wegenka UM,Nakayama T,Niess JH
12-6988 was used in Flow cytometry/Cell sorting to demonstrate that CD69 knockout can modulate mucosal CD4 T cells and increase colitis levels in a mouse transfer model of the disease.
Wed Feb 15 00:00:00 UTC 2012
Mouse CD11b+Gr-1+ myeloid cells can promote Th17 cell differentiation and experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Yi H,Guo C,Yu X,Zuo D,Wang XY
12-6988 was used in Flow cytometry/Cell sorting to investigate the role of myeloid-derived suppressor cells (MDSCs) in experimental autoimmune encephalomyelitis (EAE) development in mice.
Thu Nov 01 00:00:00 UTC 2012
The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-cell 17 population.
Stem cells and development
Svobodova E,Krulova M,Zajicova A,Pokorna K,Prochazkova J,Trosan P,Holan V
12-6988 was used in Flow cytometry/Cell sorting to demonstrate the importance of MSCs in regulating differentiation and development of Th17 cells from naive CD4+CD25- precursors.
Tue Apr 10 00:00:00 UTC 2012
Aryl Hydrocarbon Receptor-Mediated Perturbations in Gene Expression during Early Stages of CD4(+) T-cell Differentiation.
Frontiers in immunology
Rohlman D,Pham D,Yu Z,Steppan LB,Kerkvliet NI
12-6988 was used in Flow cytometry/Cell sorting to characterise the influence of 2,3,7,8-tetrachlorodibenzo-p-dioxin-activated aryl hydrocarbon receptor on gene expression during CD4+ T-cell differentiation.
Thu Aug 23 00:00:00 UTC 2012
Mapping of NKp46(+) Cells in Healthy Human Lymphoid and Non-Lymphoid Tissues.
Frontiers in immunology
Tomasello E,Yessaad N,Gregoire E,Hudspeth K,Luci C,Mavilio D,Hardwigsen J,Vivier E
12-6988 was used in Flow cytometry/Cell sorting to establish the basis for analyzing quantitative and qualitative changes of NK cell and ILC subsets in human diseases.
Wed Nov 28 00:00:00 UTC 2012
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.
Nature immunology
Monticelli LA,Sonnenberg GF,Abt MC,Alenghat T,Ziegler CG,Doering TA,Angelosanto JM,Laidlaw BJ,Yang CY,Sathaliyawala T,Kubota M,Turner D,Diamond JM,Goldrath AW,Farber DL,Collman RG,Wherry EJ,Artis D
12-6988 was used in Flow cytometry/Cell sorting to demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after viral replication.
Tue Nov 01 00:00:00 UTC 2011
Identity, regulation and in vivo function of gut NKp46+RORγt+ and NKp46+RORγt- lymphoid cells.
The EMBO journal
Reynders A,Yessaad N,Vu Manh TP,Dalod M,Fenis A,Aubry C,Nikitas G,Escalière B,Renauld JC,Dussurget O,Cossart P,Lecuit M,Vivier E,Tomasello E
12-6988 was used in Flow cytometry/Cell sorting to study how NKp46(+) ILC heterogeneity is associated with transcriptional programmes and effector functions that govern their implication in gut innate immunity.
Fri Jun 17 00:00:00 UTC 2011
Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
LaCasse CJ,Janikashvili N,Larmonier CB,Alizadeh D,Hanke N,Kartchner J,Situ E,Centuori S,Har-Noy M,Bonnotte B,Katsanis E,Larmonier N
12-6988 was used in Flow cytometry/Cell sorting to investigate the regulation of murine dendritic cell cytotoxic functions by T lymphocytes.
Thu Dec 15 00:00:00 UTC 2011
A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity.
Journal of immunology (Baltimore, Md. : 1950)
Fujimoto K,Karuppuchamy T,Takemura N,Shimohigoshi M,Machida T,Haseda Y,Aoshi T,Ishii KJ,Akira S,Uematsu S
12-6988 was used in Flow cytometry/Cell sorting to characterise CD8α(+) dendritic cells in the lamina propria of the small intestine.
Wed Jun 01 00:00:00 UTC 2011
Low-strength T-cell activation promotes Th17 responses.
Blood
Purvis HA,Stoop JN,Mann J,Woods S,Kozijn AE,Hambleton S,Robinson JH,Isaacs JD,Anderson AE,Hilkens CM
12-6988 was used in Flow cytometry/Cell sorting to investigate the role of strength of T cell stimulation on IL-17 production.
Thu Dec 02 00:00:00 UTC 2010
IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors.
The Journal of experimental medicine
Satoh-Takayama N,Lesjean-Pottier S,Vieira P,Sawa S,Eberl G,Vosshenrich CA,Di Santo JP
12-6988 was used in Flow cytometry/Cell sorting to highlight the independent cytokine regulation of functionally diverse intestinal NKp46(+) cell subsets.
Mon Feb 15 00:00:00 UTC 2010
IL-1β-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells.
Journal of immunology (Baltimore, Md. : 1950)
Li L,Kim J,Boussiotis VA
Fri Oct 01 00:00:00 UTC 2010
FOXP3+ regulatory T cells and T helper 1, T helper 2, and T helper 17 cells in human early pregnancy decidua.
Biology of reproduction
Mjösberg J,Berg G,Jenmalm MC,Ernerudh J
12-6988 was used in Flow cytometry/Cell sorting to study the chemokine receptor expression profiles in human pregnancy decidua to monitor levels of TH1, TH2, TH17 and Treg cells.
Thu Apr 01 00:00:00 UTC 2010
Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells.
Journal of immunology (Baltimore, Md. : 1950)
Schmutz S,Bosco N,Chappaz S,Boyman O,Acha-Orbea H,Ceredig R,Rolink AG,Finke D
Sat Aug 15 00:00:00 UTC 2009
The natural cytotoxicity receptor NKp46 is dispensable for IL-22-mediated innate intestinal immune defense against Citrobacter rodentium.
Journal of immunology (Baltimore, Md. : 1950)
Satoh-Takayama N,Dumoutier L,Lesjean-Pottier S,Ribeiro VS,Mandelboim O,Renauld JC,Vosshenrich CA,Di Santo JP
12-6988 was used in Flow cytometry/Cell sorting to investigate the role of NKp46 cells in intestinal homeostasis and immune defence.
Sun Nov 15 00:00:00 UTC 2009
Lack of IL-6 during coxsackievirus infection heightens the early immune response resulting in increased severity of chronic autoimmune myocarditis.
PloS one
Poffenberger MC,Straka N,El Warry N,Fang D,Shanina I,Horwitz MS
Thu Jul 09 00:00:00 UTC 2009
