Product References
CARM1 regulates replication fork speed and stress response by stimulating PARP1.
Molecular cell
Genois MM,Gagné JP,Yasuhara T,Jackson J,Saxena S,Langelier MF,Ahel I,Bedford MT,Pascal JM,Vindigni A,Poirier GG,Zou L
MA1-26418 was used in Miscellaneous to show that CARM1 associates with replication forks and reduces fork speed independently of its methyltransferase activity.
Thu Feb 18 00:00:00 UTC 2021
NSMF promotes the replication stress-induced DNA damage response for genome maintenance.
Nucleic acids research
Ju MK,Shin KJ,Lee JR,Khim KW,A Lee E,Ra JS,Kim BG,Jo HS,Yoon JH,Kim TM,Myung K,Choi JH,Kim H,Chae YC
MA1-26418 was used in Immunocytochemistry-immunoflourescence to identify the N-methyl-D-aspartate receptor synaptonuclear signaling and neuronal migration factor (NSMF) as a key replication stress response factor that is important for ataxia telangiectasia and Rad3-related protein (ATR) activation.
Fri Jun 04 00:00:00 UTC 2021
NSMF promotes the replication stress-induced DNA damage response for genome maintenance.
Nucleic acids research
Ju MK,Shin KJ,Lee JR,Khim KW,A Lee E,Ra JS,Kim BG,Jo HS,Yoon JH,Kim TM,Myung K,Choi JH,Kim H,Chae YC
MA1-26418 was used in Immunocytochemistry-immunoflourescence to identify the N-methyl-D-aspartate receptor synaptonuclear signaling and neuronal migration factor (NSMF) as a key replication stress response factor that is important for ataxia telangiectasia and Rad3-related protein (ATR) activation.
Fri Jun 04 00:00:00 UTC 2021
NSMF promotes the replication stress-induced DNA damage response for genome maintenance.
Nucleic acids research
Ju MK,Shin KJ,Lee JR,Khim KW,A Lee E,Ra JS,Kim BG,Jo HS,Yoon JH,Kim TM,Myung K,Choi JH,Kim H,Chae YC
MA1-26418 was used in Immunocytochemistry-immunoflourescence to identify the N-methyl-D-aspartate receptor synaptonuclear signaling and neuronal migration factor (NSMF) as a key replication stress response factor that is important for ataxia telangiectasia and Rad3-related protein (ATR) activation.
Fri Jun 04 00:00:00 UTC 2021
DDX11 loss causes replication stress and pharmacologically exploitable DNA repair defects.
Proceedings of the National Academy of Sciences of the United States of America
Jegadesan NK,Branzei D
MA1-26418 was used in Immunocytochemistry to find that DDX11 helicase activity prevents chemotherapy drug hypersensitivity and accumulation of DNA damage.
Tue Apr 27 00:00:00 UTC 2021
DDX11 loss causes replication stress and pharmacologically exploitable DNA repair defects.
Proceedings of the National Academy of Sciences of the United States of America
Jegadesan NK,Branzei D
MA1-26418 was used in Immunocytochemistry to find that DDX11 helicase activity prevents chemotherapy drug hypersensitivity and accumulation of DNA damage.
Tue Apr 27 00:00:00 UTC 2021
APE1 senses DNA single-strand breaks for repair and signaling.
Nucleic acids research
Lin Y,Raj J,Li J,Ha A,Hossain MA,Richardson C,Mukherjee P,Yan S
MA1-26418 was used in Western Blotting to demonstrate a two-step APE1/APE2-mediated mechanism for DNA single-strand break (SSB) end resection that couples DNA damage response with SSB repair in a eukaryotic system.
Fri Feb 28 00:00:00 UTC 2020
Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination.
Genes & development
Moquin DM,Genois MM,Zhang JM,Ouyang J,Yadav T,Buisson R,Yazinski SA,Tan J,Boukhali M,Gagné JP,Poirier GG,Lan L,Haas W,Zou L
Published figure using RPA2 monoclonal antibody (Product # MA1-26418) in Western Blot
Tue Jan 01 00:00:00 UTC 2019
Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1.
Molecular cell
Nguyen HD,Yadav T,Giri S,Saez B,Graubert TA,Zou L
Published figure using RPA2 monoclonal antibody (Product # MA1-26418) in Immunoprecipitation
Thu Mar 02 00:00:00 UTC 2017
Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1.
Molecular cell
Nguyen HD,Yadav T,Giri S,Saez B,Graubert TA,Zou L
Published figure using RPA2 monoclonal antibody (Product # MA1-26418) in Immunoprecipitation
Thu Mar 02 00:00:00 UTC 2017
Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1.
Molecular cell
Nguyen HD,Yadav T,Giri S,Saez B,Graubert TA,Zou L
Published figure using RPA2 monoclonal antibody (Product # MA1-26418) in Immunoprecipitation
Thu Mar 02 00:00:00 UTC 2017
Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.
Molecular cell
Taglialatela A,Alvarez S,Leuzzi G,Sannino V,Ranjha L,Huang JW,Madubata C,Anand R,Levy B,Rabadan R,Cejka P,Costanzo V,Ciccia A
MA1-26418 was used in Proximity Ligation Assay to investigate if the depletion of SMARCAL1, a SNF2-family DNA translocase that remodels stalled forks, restores replication fork stability and reduces the formation of replication stress-induced DNA breaks and chromosomal aberrations in BRCA1/2-deficient cells.
Thu Oct 19 00:00:00 UTC 2017
A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination.
Nucleic acids research
Dubois JC,Yates M,Gaudreau-Lapierre A,Clément G,Cappadocia L,Gaudreau L,Zou L,Maréchal A
MA1-26418 was used in Western Blotting to suggest that RPA phosphorylation enhances the recruitment of PRP19 to RPA-ssDNA and stimulates RPA ubiquitylation through a process requiring both PRP19 and RFWD3, thereby triggering a phosphorylation-ubiquitylation circuitry that promotes ATR activation and HR.
Wed Sep 06 00:00:00 UTC 2017
A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination.
Nucleic acids research
Dubois JC,Yates M,Gaudreau-Lapierre A,Clément G,Cappadocia L,Gaudreau L,Zou L,Maréchal A
MA1-26418 was used in Western Blotting to suggest that RPA phosphorylation enhances the recruitment of PRP19 to RPA-ssDNA and stimulates RPA ubiquitylation through a process requiring both PRP19 and RFWD3, thereby triggering a phosphorylation-ubiquitylation circuitry that promotes ATR activation and HR.
Wed Sep 06 00:00:00 UTC 2017
A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination.
Nucleic acids research
Dubois JC,Yates M,Gaudreau-Lapierre A,Clément G,Cappadocia L,Gaudreau L,Zou L,Maréchal A
MA1-26418 was used in Western Blotting to suggest that RPA phosphorylation enhances the recruitment of PRP19 to RPA-ssDNA and stimulates RPA ubiquitylation through a process requiring both PRP19 and RFWD3, thereby triggering a phosphorylation-ubiquitylation circuitry that promotes ATR activation and HR.
Wed Sep 06 00:00:00 UTC 2017
ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1.
Nature communications
Moiseeva T,Hood B,Schamus S,O'Connor MJ,Conrads TP,Bakkenist CJ
MA1-26418 was used in Immunocytochemistry to describe proteomic analyses that identified mechanisms through which ATR kinase inhibitors induce unscheduled origin firing in undamaged cells.
Thu Nov 09 00:00:00 UTC 2017
ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1.
Nature communications
Moiseeva T,Hood B,Schamus S,O'Connor MJ,Conrads TP,Bakkenist CJ
MA1-26418 was used in Immunocytochemistry to describe proteomic analyses that identified mechanisms through which ATR kinase inhibitors induce unscheduled origin firing in undamaged cells.
Thu Nov 09 00:00:00 UTC 2017
PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sites.
Oncogene
Mortusewicz O,Evers B,Helleday T
MA1-26418 was used in immunocytochemistry to investigate the effect of PC4 on genome stability and DNA repair
Thu Feb 11 00:00:00 UTC 2016
DNA end resection is needed for the repair of complex lesions in G1-phase human cells.
Cell cycle (Georgetown, Tex.)
Averbeck NB,Ringel O,Herrlitz M,Jakob B,Durante M,Taucher-Scholz G
MA1-26418 was used in immunocytochemistry to study double stranded break repair during different stages of the cell cycle.
Wed Aug 19 00:00:00 UTC 2015
Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome.
DNA repair
Quinet A,Vessoni AT,Rocha CR,Gottifredi V,Biard D,Sarasin A,Menck CF,Stary A
MA1-26418 was used in immunocytochemistry to study the tolerance of human cells to DNA damage resulting from low-dose UV exposure and the roles of replication fork gap-filling and bypass in this tolerance
Sat Feb 01 00:00:00 UTC 2014
Replication stress links structural and numerical cancer chromosomal instability.
Nature
Burrell RA,McClelland SE,Endesfelder D,Groth P,Weller MC,Shaikh N,Domingo E,Kanu N,Dewhurst SM,Gronroos E,Chew SK,Rowan AJ,Schenk A,Sheffer M,Howell M,Kschischo M,Behrens A,Helleday T,Bartek J,Tomlinson IP,Swanton C
MA1-26418 was used in immunocytochemistry to study the role of replication stress in cancer chromosomal instability
Thu Feb 28 00:00:00 UTC 2013
Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes.
Proceedings of the National Academy of Sciences of the United States of America
Schaetzlein S,Chahwan R,Avdievich E,Roa S,Wei K,Eoff RL,Sellers RS,Clark AB,Kunkel TA,Scharff MD,Edelmann W
MA1-26418 was used in immunocytochemistry to study the catalytic and structural involvement of mammalian exonuclease-1 in a range of biological processes
Tue Jul 02 00:00:00 UTC 2013
Differential contribution of HP1 proteins to DNA end resection and homology-directed repair.
Cell cycle (Georgetown, Tex.)
Soria G,Almouzni G
MA1-26418 was used in western blot to study the roles of human HP1 paralogues in homology-directed repair
Fri Feb 01 00:00:00 UTC 2013
Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage.
Cell cycle (Georgetown, Tex.)
Hu R,Wang E,Peng G,Dai H,Lin SY
MA1-26418 was used in immunocytochemistry and western blot to examine the interaction between zinc finger protein 668 interacts and and its effect on H2AX acetylation after DNA damage
Mon Jul 01 00:00:00 UTC 2013
BLM SUMOylation regulates ssDNA accumulation at stalled replication forks.
Frontiers in genetics
Ouyang KJ,Yagle MK,Matunis MJ,Ellis NA
MA1-26418 was used in immunocytochemistry and western blot to study the mechanism by which SUMOylation of the BLM helicase modulates the accumulation of single-stranded DNA at stalled replication forks
Thu Sep 12 00:00:00 UTC 2013
Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination.
PloS one
Lam T,Thomas LM,White CA,Li G,Pone EJ,Xu Z,Casali P
MA1-26418 was used in immunocytochemistry to study the role of 14-3-3 adaptor scaffold function in immunoglobulin class switch DNA recombination in B-cells
Fri Jan 02 00:00:00 UTC 2015
REV1 and polymerase ζ facilitate homologous recombination repair.
Nucleic acids research
Sharma S,Hicks JK,Chute CL,Brennan JR,Ahn JY,Glover TW,Canman CE
MA1-26418 was used in immunocytochemistry to study the mechanisms by which REV1 and polymerase-zeta contribute to homologous recombination repair
Sun Jan 01 00:00:00 UTC 2012
Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption.
Molecular and cellular biology
Beck H,Nähse-Kumpf V,Larsen MS,O'Hanlon KA,Patzke S,Holmberg C,Mejlvang J,Groth A,Nielsen O,Syljuåsen RG,Sørensen CS
MA1-26418 was used in flow cytometry to study the role of CDK in the mechanism by which WEE1 kinase maintains genomic integrity
Mon Oct 01 00:00:00 UTC 2012
Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.
Cell
Kratz K,Schöpf B,Kaden S,Sendoel A,Eberhard R,Lademann C,Cannavó E,Sartori AA,Hengartner MO,Jiricny J
MA1-26418 was used in immunocytochemistry to study the role of KIAA1018/FAN1 depletion in increased cell sensitivity to DNA interstrand cross-linking agents
Fri Jul 09 00:00:00 UTC 2010
ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968.
Cancer letters
Zuco V,Benedetti V,Zunino F
MA1-26418 was used in western blot to investigate the effect of ST1968 on the induction of DNA damage response
Mon Jun 28 00:00:00 UTC 2010
Sensitization of ovarian carcinoma cells to the atypical retinoid ST1926 by the histone deacetylase inhibitor, RC307: enhanced DNA damage response.
International journal of cancer
Zuco V,Benedetti V,De Cesare M,Zunino F
MA1-26418 was used in western blot to investigate the therapeutic benefit of histone deacetylase inhibitor RC307 in the treatment of ovarian carcinoma with ST1926
Mon Mar 01 00:00:00 UTC 2010
The NER proteins are differentially expressed in ever smokers and in never smokers with lung adenocarcinoma.
Annals of oncology : official journal of the European Society for Medical Oncology
Planchard D,Domont J,Taranchon E,Monnet I,Tredaniel J,Caliandro R,Validire P,Besse B,Soria JC,Fouret P
MA1-26418 was used in immunohistochemistry to investigate ERCC1, RPA and XPF expression in different types of smokers with lung adenocarcinoma
Wed Jul 01 00:00:00 UTC 2009
Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis.
Nucleic acids research
Stephan H,Concannon C,Kremmer E,Carty MP,Nasheuer HP
MA1-26418 was used in western blot to study ionizing radiation-dependent phosphorylation of the 32-kDa subunit of replication protein A during mitosis
Thu Oct 01 00:00:00 UTC 2009
The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells.
The EMBO journal
Watrin E,Peters JM
MA1-26418 was used in immunocytochemistry to study the role of the cohesin complex in the DNA damage-induced G2/M checkpoint in mammalian cells
Wed Sep 02 00:00:00 UTC 2009
Gamma-glutamyltransferase-dependent resistance to arsenic trioxide in melanoma cells and cellular sensitization by ascorbic acid.
Free radical biology & medicine
Giommarelli C,Corti A,Supino R,Favini E,Paolicchi A,Pompella A,Zunino F
MA1-26418 was used in western blot to investigate the effect of some combination of prooxidant agents on overcoming melanoma cellular tolerance to oxidative stress
Mon Jun 01 00:00:00 UTC 2009
Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities.
The Journal of cell biology
Fugger K,Mistrik M,Danielsen JR,Dinant C,Falck J,Bartek J,Lukas J,Mailand N
MA1-26418 was used in immunohistochemistry and western blot to study the mechanisms by which human Fbh1 helicase contributes to genome maintenance
Mon Sep 07 00:00:00 UTC 2009
Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks.
DNA repair
Lange SS,Reddy MC,Vasquez KM
MA1-26418 was used in EMSA to investigate the role of HMGB1 in Psoralen-induced DNA damage repair
Sat Jul 04 00:00:00 UTC 2009
Cellular response to oxidative stress and ascorbic acid in melanoma cells overexpressing gamma-glutamyltransferase.
European journal of cancer (Oxford, England : 1990)
Giommarelli C,Corti A,Supino R,Favini E,Paolicchi A,Pompella A,Zunino F
MA1-26418 was used in western blot to investigate the role of gamma-glutamyltransferase in drug resistence toward cancer chemotherapy agents
Sat Mar 01 00:00:00 UTC 2008
Distinct functions of POT1 at telomeres.
Molecular and cellular biology
Barrientos KS,Kendellen MF,Freibaum BD,Armbruster BN,Etheridge KT,Counter CM
MA1-26418 was used in immunohistochemistry to investigate the protective role of POT1 in telomeres
Mon Sep 01 00:00:00 UTC 2008
Mobility and distribution of replication protein A in living cells using fluorescence correlation spectroscopy.
Experimental and molecular pathology
Braet C,Stephan H,Dobbie IM,Togashi DM,Ryder AG,Földes-Papp Z,Lowndes N,Nasheuer HP
MA1-26418 was used in western blot to investigate the mechanistic processes of replication protein A fucntion in DNA metabolism
Sun Apr 01 00:00:00 UTC 2007
Development of resistance to the atypical retinoid, ST1926, in the lung carcinoma cell line H460 is associated with reduced formation of DNA strand breaks and a defective DNA damage response.
Neoplasia (New York, N.Y.)
Zuco V,Zanchi C,Lanzi C,Beretta GL,Supino R,Pisano C,Barbarino M,Zanier R,Bucci F,Aulicino C,Carminati P,Zunino F
MA1-26418 was used in western blot to investigate the mechanism for the development of ST1926 resistence in lung carcinoma cell line H460
Fri Jul 01 00:00:00 UTC 2005
Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha.
Molecular cell
Ricke RM,Bielinsky AK
MA1-26418 was used in immunoprecipitation to study the role of the DNA replication factor Mcm10 in regulating DNA polymerase alpha stability and chromatin association
Fri Oct 22 00:00:00 UTC 2004
The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene.
Molecular and cellular biology
Sukhodolets KE,Hickman AB,Agarwal SK,Sukhodolets MV,Obungu VH,Novotny EA,Crabtree JS,Chandrasekharappa SC,Collins FS,Spiegel AM,Burns AL,Marx SJ
MA1-26418 was used in western blot to study the interaction between a replication protein A subunit and MEN1 tumor suppressor gene product
Wed Jan 01 00:00:00 UTC 2003
