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Invitrogen
RPE65 Monoclonal Antibody (401.8B11.3D9), Biotin
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Product Details
MA5-16040
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Chicken,
Human,
Mouse,
Non-human primate,
Pig,
Rat,
Xenopus
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
401.8B11.3D9
Immunogen
Bovine RPE microsomal membrane proteins.
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11153223
Target Information
RPE65 is a major protein of the retinal pigment epithelium (RPE). RPE65 is essential for the regeneration of rhodopsin in the visual cycle. Mutations in RPE65 are responsible for certain forms of autosomal recessive severe retinal dystrophy, including Leber Congenital Amaurosis (LCA). Loss of function results in a block in retinoid processing required for the synthesis of 11-cis retinal and the accumulation of retinyl esters in the RPE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: All-trans-retinyl-palmitate hydrolase; BCO family, member 3; Lutein isomerase; Meso-zeaxanthin isomerase; modifier of retinal degeneration 1; p63; RBP-binding membrane protein; retinal pigment epithelium 65-like; retinal pigment epithelium abundant protein RPE65; retinal pigment epithelium specific protein 65; retinal pigment epithelium, 65 kDa; Retinal pigment epithelium-specific 65 kDa protein; retinal pigment epithelium-specific protein (65kD); retinal pigment epithelium-specific protein 65kDa; Retinitis pigmentos; retinitis pigmentosa 20 (autosomal recessive); Retinoid isomerohydrolase; Retinol isomerase; rpe65 gene for retinal pigment epithelium-specific protein; truncated RPE65
Gene Aliases: 65kDa; A930029L06Rik; BCO3; BOS_3433; LCA2; Mord1; mRPE65; rd12; RP20; RPE65; sRPE65
UniProt ID: (Chicken) Q9YGX2, (Bovine) Q28175, (Dog) Q9TVB8, (Human) Q16518, (Mouse) Q91ZQ5, (Rat) O70276
Entrez Gene ID: (Chicken) 395700, (Bovine) 282043, (Dog) 403803, (Human) 6121, (Mouse) 19892, (Rat) 89826
isomerase activity
metal ion binding
all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity
all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
retinal isomerase activity
phosphatidylserine binding
phosphatidylcholine binding
cardiolipin binding
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
hydrolase activity
visual perception
response to stimulus
retina homeostasis
neural retina development
regulation of rhodopsin gene expression
insulin receptor signaling pathway
retinol metabolic process
retinal metabolic process
detection of light stimulus involved in visual perception
retina development in camera-type eye
retina morphogenesis in camera-type eye
cellular response to electrical stimulus
circadian rhythm
response to light stimulus
camera-type eye development
retinoid metabolic process
vitamin A metabolic process
oxidation-reduction process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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