Proteintech

RPL23 Polyclonal Antibody

RPL23 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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RPL23 Antibody (16086-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human brain tissue slide using 16086-1-AP ( RPL23 Antibody) at dilution of 1:200 (under 40x lens).

Product Image Gallery

Product Details

16086-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Not applicable (N/A)

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RPL23 Fusion Protein Ag9120 (1-140 aa encoded by BC010114)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSKRGRGGS SGAKFRISLG LPVGAVINCA DNTGAKNLYI ISVKGIKGRL NRLPAAGVGD MVMATVKKGK PELRKKVHPA VVIRQRKSYR RKDGVFLYFE DNAGVIVNNK GEMKGSAITG PVAKECADLW PRIASNAGSI A (1-140 aa encoded by BC010114)

Target Information

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Human hematopoietic stem cell vulnerability to ferroptosis.

Cell

Zhao J,Jia Y,Mahmut D,Deik AA,Jeanfavre S,Clish CB,Sankaran VG

Thu Feb 16 00:00:00 UTC 2023

Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome surveillance.

Nature

Shan L,Xu G,Yao RW,Luan PF,Huang Y,Zhang PH,Pan YH,Zhang L,Gao X,Li Y,Cao SM,Gao SX,Yang ZH,Li S,Yang LZ,Wang Y,Wong CCL,Yu L,Li J,Yang L,Chen LL

Wed Mar 01 00:00:00 UTC 2023

Targeting RPL23 restores chemosensitivity of cisplatin-resistant ovarian carcinoma by inhibiting EMT.

Cytotechnology

Liu Y,Lai S,He J,Wan J,Fu F,Jinlong Y

Wed Jun 01 00:00:00 UTC 2022

Targeting RPL23 restores chemosensitivity of cisplatin-resistant ovarian carcinoma by inhibiting EMT.

Cytotechnology

Liu Y,Lai S,He J,Wan J,Fu F,Jinlong Y

Wed Jun 01 00:00:00 UTC 2022

Ribosomal Protein L23 Drives the Metastasis of Hepatocellular Carcinoma via Upregulating MMP9.

Frontiers in oncology

Yang M,Zhou Y,Deng H,Zhou H,Cheng S,Zhang D,He X,Mai L,Chen Y,Chen J

Wed Nov 06 00:00:00 UTC 2024

Ribosomal Protein L23 Drives the Metastasis of Hepatocellular Carcinoma via Upregulating MMP9.

Frontiers in oncology

Yang M,Zhou Y,Deng H,Zhou H,Cheng S,Zhang D,He X,Mai L,Chen Y,Chen J

Wed Nov 06 00:00:00 UTC 2024

Ribosomal Protein L23 Drives the Metastasis of Hepatocellular Carcinoma via Upregulating MMP9.

Frontiers in oncology

Yang M,Zhou Y,Deng H,Zhou H,Cheng S,Zhang D,He X,Mai L,Chen Y,Chen J

Wed Nov 06 00:00:00 UTC 2024

Ribosomal Protein L23 Drives the Metastasis of Hepatocellular Carcinoma via Upregulating MMP9.

Frontiers in oncology

Yang M,Zhou Y,Deng H,Zhou H,Cheng S,Zhang D,He X,Mai L,Chen Y,Chen J

Wed Nov 06 00:00:00 UTC 2024

Proteomics profiling and pathway analysis of hippocampal aging in rhesus monkeys.

BMC neuroscience

Meng S,Xia W,Pan M,Jia Y,He Z,Ge W

Wed Jan 15 00:00:00 UTC 2020

Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells.

Oncology reports

Wang J,Zhang ZQ,Li FQ,Chen JN,Gong X,Cao BB,Wang W

Mon Jun 01 00:00:00 UTC 2020

Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling.

The EMBO journal

Evans HT,Benetatos J,van Roijen M,Bodea LG,Götz J

Mon Jul 01 00:00:00 UTC 2019

Altered expression of insulin-degrading enzyme and regulator of calcineurin in the rat intracerebral streptozotocin model and human apolipoprotein E-ε4-associated Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)

Delikkaya B,Moriel N,Tong M,Gallucci G,de la Monte SM

Sun Dec 01 00:00:00 UTC 2019

Therapeutic Advantages of Dual Targeting of PPAR-δ and PPAR-γ in an Experimental Model of Sporadic Alzheimer's Disease.

Journal of Parkinson's disease and Alzheimer's disease

Reich D,Gallucci G,Tong M,de la Monte SM

Tue May 01 00:00:00 UTC 2018

LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency.

Nature cell biology

Tsanov KM,Pearson DS,Wu Z,Han A,Triboulet R,Seligson MT,Powers JT,Osborne JK,Kane S,Gygi SP,Gregory RI,Daley GQ

Sun Jan 01 00:00:00 UTC 2017

LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency.

Nature cell biology

Tsanov KM,Pearson DS,Wu Z,Han A,Triboulet R,Seligson MT,Powers JT,Osborne JK,Kane S,Gygi SP,Gregory RI,Daley GQ

Sun Jan 01 00:00:00 UTC 2017

Improved Brain Insulin/IGF Signaling and Reduced Neuroinflammation with T3D-959 in an Experimental Model of Sporadic Alzheimer's Disease.

Journal of Alzheimer's disease : JAD

de la Monte SM,Tong M,Schiano I,Didsbury J

Thu Feb 22 00:00:00 UTC 2018

Improved Brain Insulin/IGF Signaling and Reduced Neuroinflammation with T3D-959 in an Experimental Model of Sporadic Alzheimer's Disease.

Journal of Alzheimer's disease : JAD

de la Monte SM,Tong M,Schiano I,Didsbury J

Thu Feb 22 00:00:00 UTC 2018

Ribosomal protein L23 negatively regulates cellular apoptosis via the RPL23/Miz-1/c-Myc circuit in higher-risk myelodysplastic syndrome.

Scientific reports

Qi Y,Li X,Chang C,Xu F,He Q,Zhao Y,Wu L

Wed May 24 00:00:00 UTC 2017

Ribosomal protein L23 negatively regulates cellular apoptosis via the RPL23/Miz-1/c-Myc circuit in higher-risk myelodysplastic syndrome.

Scientific reports

Qi Y,Li X,Chang C,Xu F,He Q,Zhao Y,Wu L

Wed May 24 00:00:00 UTC 2017

Ribosomal protein L23 negatively regulates cellular apoptosis via the RPL23/Miz-1/c-Myc circuit in higher-risk myelodysplastic syndrome.

Scientific reports

Qi Y,Li X,Chang C,Xu F,He Q,Zhao Y,Wu L

Wed May 24 00:00:00 UTC 2017

Ribosomal protein L23 negatively regulates cellular apoptosis via the RPL23/Miz-1/c-Myc circuit in higher-risk myelodysplastic syndrome.

Scientific reports

Qi Y,Li X,Chang C,Xu F,He Q,Zhao Y,Wu L

Wed May 24 00:00:00 UTC 2017

Tobacco Smoke Exposure Impairs Brain Insulin/IGF Signaling: Potential Co-Factor Role in Neurodegeneration.

Journal of Alzheimer's disease : JAD

Deochand C,Tong M,Agarwal AR,Cadenas E,de la Monte SM

Fri Nov 04 00:00:00 UTC 2016

T3D-959: A Multi-Faceted Disease Remedial Drug Candidate for the Treatment of Alzheimer's Disease.

Journal of Alzheimer's disease : JAD

Tong M,Deochand C,Didsbury J,de la Monte SM

Tue Dec 13 00:00:00 UTC 2016

Defective ribosome assembly in Shwachman-Diamond syndrome.

Blood

Wong CC,Traynor D,Basse N,Kay RR,Warren AJ

Thu Oct 20 00:00:00 UTC 2011

Defective ribosome assembly in Shwachman-Diamond syndrome.

Blood

Wong CC,Traynor D,Basse N,Kay RR,Warren AJ

Thu Oct 20 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: 60S ribosomal protein L17; 60S ribosomal protein L23; Large ribosomal subunit protein uL14; MGC111167; MGC117346; MGC72008; ribosomal protein L17

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Gene Aliases: 2810009A01Rik; L23; rpL17; RPL23

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UniProt ID: (Human) P62829, (Mouse) P62830, (Rat) P62832

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Entrez Gene ID: (Human) 9349, (Mouse) 65019, (Rat) 29282

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Function(s)

structural constituent of ribosome protein binding poly(A) RNA binding large ribosomal subunit rRNA binding

Process(es)

translation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing translational initiation ribosomal protein import into nucleus SRP-dependent cotranslational protein targeting to membrane viral transcription

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RPL23 Polyclonal Antibody

RPL23 Antibody (16086-1-AP) in IHC (P)

Product Details

16086-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

RNA Immunoprecipitation (RIP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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