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Immunogen sequence: MDTSRVQPI KLARVTKVLG RTGSQGQCTQ VRVEFMDDTS RSIIRNVKGP VREGDVLTLL ESEREARRLR (1-69 aa encoded by BC000354 )
TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 40S ribosomal protein S28; Small ribosomal subunit protein eS28
Gene Aliases: DBA15; RPS28; S28
UniProt ID: (Human) P62857, (Mouse) P62858, (Rat) P62859
Entrez Gene ID: (Human) 6234, (Mouse) 54127, (Rat) 691531
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