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Invitrogen
RPSA Polyclonal Antibody
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RPSA Antibody (PA5-27281) in IHC (P)
RPSA Polyclonal Antibody detects RPSA protein at cytoplasm on mouse small intestine by immunohistochemical analysis. Sample: Paraffin-embedded mouse small intestine. RPSA Polyclonal Antibody (Product # PA5-27281) diluted at 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-27281
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human RPSA. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2544757
Product Specific Information
Recommended positive controls: HepG2, Jurkat, Mouse brain.
Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (93%), Xenopus laevis (95%), Dog (100%), Pig (100%), Chicken (98%), Sheep (99%), Rhesus Monkey (100%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 37 kDa laminin receptor; 37 kDa laminin receptor precursor; 37 kDa oncofetal antigen; 37/67 kDa laminin receptor; 37LRP; 40S ribosomal protein SA; 67 kDa laminin receptor; 67LR; Colon carcinoma laminin-binding protein; Laminin receptor 1; laminin receptor 1 (67kD, ribosomal protein SA); Laminin-binding protein precursor p40; LamR; LBP/p40; LRP/LR; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; OFA/iLRP; P40-3, functional; P40-8, functional; rssa; Small ribosomal subunit protein uS2
Gene Aliases: 37LRP; 67kDa; 67LR; AL022858; ICAS; LAMBR; Lamr; LAMR1; Lamrl1; LBP; LBP/p40; LRP; LRP/LR; MLR; NEM/1CHD4; P40; P40-3; P40-8; RPSA; SA
UniProt ID: (Human) P08865, (Mouse) P14206
Entrez Gene ID: (Human) 3921, (Mouse) 16785
ribosomal small subunit assembly
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
rRNA export from nucleus
translation
single organismal cell-cell adhesion
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
rRNA processing
translational initiation
SRP-dependent cotranslational protein targeting to membrane
cell adhesion
viral transcription
viral entry into host cell
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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