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Invitrogen
RPSA Monoclonal Antibody (RP-01), Alexa Fluor™ 488
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FIGURE: 1 / 2
RPSA Antibody (MA5-44138) in Flow
Separation of human lymphocytes stained using anti-human RPSA (RP-01) Alexa Fluor® 488 Monoclonal antibody (Product # MA5-44138), concentration in sample 9 µg/mL (red-filled) from human lymphocytes stained using mouse isotype control Alexa Fluor® 488 antibody (concentration in sample 9 µg/mL, black-dashed) in flow cytometry analysis (intracellular staining) of human peripheral whole blood.
Product Details
MA5-44138
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Chicken,
Human,
Mouse,
Xenopus
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
RP-01
Immunogen
REPRLLVVTDPRADHQP
Conjugate
Excitation/Emission Max
499/520 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Purification
Size-exclusion chromatography
Storage buffer
PBS with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913070
Product Specific Information
This antibody recognizes ribosomal protein SA (RPSA), which is important for formation and stability of 40S ribosomal subunit, and is overexpressed in many carcinomas.
Target Information
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 37 kDa laminin receptor; 37 kDa laminin receptor precursor; 37 kDa oncofetal antigen; 37-kd LR; 37/67 kDa laminin receptor; 37kD Laminin receptor; 37LRP; 40S ribosomal protein SA; 67 kDa laminin receptor; 67-kd LR; 67kD laminin receptor; 67LR; Colon carcinoma laminin-binding protein; Laminin receptor 1; laminin receptor 1 (67kD, ribosomal protein SA); laminin receptor 1 (ribosomal protein SA, 67 kDA); Laminin-binding protein precursor p40; LamR; LBP/p40; LRP/LR; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; OFA/iLRP; P40-3, functional; P40-8, functional; Protein C10; ribosomal protein SA pseudogene; rssa; Small ribosomal subunit protein uS2
Gene Aliases: 37LRP; 67kDa; 67LR; AL022858; BOS_20678; DMRT1; ICAS; LAMBR; LamR; LAMR1; Lamrl1; LBP; LBP/p40; LR; LRP; LRP/LR; MLR; NEM/1CHD4; P40; P40-3; P40-8; RPSA; SA; XELAEV_18023531mg
UniProt ID: (Bovine) P26452, (Human) P08865, (Chicken) P50890, (Mouse) P14206, (Xenopus) Q3ZM03
Entrez Gene ID: (Bovine) 281898, (Human) 3921, (Chicken) 395181, (Mouse) 16785, (Xenopus) 733335
ribosomal small subunit assembly
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
rRNA export from nucleus
translation
cell adhesion
single organismal cell-cell adhesion
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
rRNA processing
translational initiation
SRP-dependent cotranslational protein targeting to membrane
viral transcription
viral entry into host cell
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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