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Product Details
H00285367-B01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RPUSD3 (NP_775930, 1 a.a. approximately 343 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MDGRRVLGRF WSGWRRGLGV RPVPEDAGFG TEARHQRQPR GSCQRSGPLG DQPFAGLLPK NLSREELVDA LRAAVVDRKG PLVTLNKPQG LPVTGKPGEL TLFSVLPELS QSLGLREQEL QVVRASGKES SGLVLLSSCP QTASRLQKYF THARRAQRPT ATYCAVTDGI PAASEGKIQA ALKLEHIDGV NLTVPVKAPS RKDILEGVKK TLSHFRVVAT GSGCALVQLQ PLTVFSSQLQ VHMVLQLCPV LGDHMYSARV GTVLGQRFLL PAENNKPQRQ VLDEALLRRL HLTPSQAAQL PLHLHLHRLL LPGTRARDTP VELLAPLPPY FSRTLQCLGL RLQ
Target Information
RNA Pseudouridine Synthase D3 (RPUSD3) is a gene that encodes a pseudouridine synthase, an enzyme responsible for catalyzing the isomerization of uridine to pseudouridine in RNA molecules. This post-transcriptional modification is crucial for the stability and function of tRNAs and rRNAs. RPUSD3, along with other pseudouridine synthases such as PUS1, PUSL1, and TRUB2, is predicted to localize to mitochondria, indicating its role in mitochondrial RNA processing and maturation. The pseudouridylation activity provided by RPUSD3 is essential for the proper folding and functionality of mitochondrial RNAs, which are fundamental for the biogenesis of the mitochondrial electron transport chain and ATP synthase. While detailed structural insights into RPUSD3 are not yet fully characterized, its enzymatic function is critical in maintaining cellular energy metabolism and overall mitochondrial health.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mitochondrial mRNA pseudouridine synthase RPUSD3; RNA pseudouridylate synthase domain-containing protein 3
Gene Aliases: RPUSD3
UniProt ID: (Human) Q6P087
Entrez Gene ID: (Human) 285367
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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