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RRAGB Polyclonal Antibody

RRAGB Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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RRAGB Antibody (13023-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human brain tissue slide using 13023-1-AP ( RRAGB Antibody) at dilution of 1:50 (under 40x lens).

RRAGB Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

13023-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RRAGB Fusion Protein Ag4116 (1-346 aa encoded by BC034726)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEESDSEKT TEKENLGPRM DPPLGEPEGS LGWVLPNTAM KKKVLLMGKS GSGKTSMRSI IFANYIARDT RRLGATIDVE HSHVRFLGNL VLNLWDCGGQ DTFMENYFTS QRDNIFRNVE VLIYVFDVES RELEKDMHYY QSCLEAILQN SPDAKIFCLV HKMDLVQEDQ RDLIFKEREE DLRRLSRPLE CSCFRTSIWD ETLYKAWSSI VYQLIPNVQQ LEMNLRNFAE IIEADEVLLF ERATFLVISH YQCKEQRDAH RFEKISNIIK QFKLSCSKLA ASFQSMEVRN SNFAAFIDIF TSNTYVMVVM SDPSIPSAAT LINIRNARKH FEKLERVDGP KQCLLMR (1-346 aa encoded by BC034726)

Target Information

Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop.

Molecular cancer

Li X,Wang J,Lin W,Yuan Q,Lu Y,Wang H,Chen Y,Chen L,Dai P,Long H,Li X

Thu Jun 23 00:00:00 UTC 2022

circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop.

Molecular cancer

Li X,Wang J,Lin W,Yuan Q,Lu Y,Wang H,Chen Y,Chen L,Dai P,Long H,Li X

Thu Jun 23 00:00:00 UTC 2022

circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop.

Molecular cancer

Li X,Wang J,Lin W,Yuan Q,Lu Y,Wang H,Chen Y,Chen L,Dai P,Long H,Li X

Thu Jun 23 00:00:00 UTC 2022

YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases.

The Journal of clinical investigation

Ikeda S,Nah J,Shirakabe A,Zhai P,Oka SI,Sciarretta S,Guan KL,Shimokawa H,Sadoshima J

Mon Mar 01 00:00:00 UTC 2021

YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases.

The Journal of clinical investigation

Ikeda S,Nah J,Shirakabe A,Zhai P,Oka SI,Sciarretta S,Guan KL,Shimokawa H,Sadoshima J

Mon Mar 01 00:00:00 UTC 2021

Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome.

PloS one

Ou X,Liu M,Luo H,Dong LQ,Liu F

Mon Jun 01 00:00:00 UTC 2015

Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome.

PloS one

Ou X,Liu M,Luo H,Dong LQ,Liu F

Mon Jun 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: GTP-binding protein ragB; Rag B; ragB; Ras-related GTP binding B; Ras-related GTP-binding protein B; RRAGB; rragB {ECO:0000312|RGD:619805}

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Gene Aliases: bA465E19.1; RAGB; RRAGB

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UniProt ID: (Human) Q5VZM2, (Rat) Q63487, (Mouse) Q6NTA4

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Entrez Gene ID: (Human) 10325, (Rat) 117043, (Mouse) 245670

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Function(s)

GTPase activity protein binding GTP binding guanyl ribonucleotide binding GDP binding nucleotide binding

Process(es)

cell cycle arrest regulation of autophagy macroautophagy regulation of TOR signaling positive regulation of TOR signaling cellular response to amino acid starvation cellular protein localization cellular response to amino acid stimulus biological_process metabolic process cellular response to starvation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RRAGB Polyclonal Antibody

RRAGB Antibody (13023-1-AP) in IHC (P)

Product Details

13023-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

RNA Immunoprecipitation (RIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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