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Invitrogen
RRM1 Monoclonal Antibody (OTI16A8)
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FIGURE: 1 / 5
RRM1 Antibody (MA5-26673) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human colon tissue. To expose target proteins, 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min was used. Following antigen retrieval, tissues were probed with a RRM1 monoclonal antibody (Product # MA5-26673).
Product Details
MA5-26673
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI16A8
Immunogen
Human recombinant protein fragment corresponding to amino acids 541-792 of RRM1 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2725270
Target Information
RRM1 (Ribonucleotide reductase M1 polypeptide) is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is involved in carcinogenesis, tumor progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: R RRM 1; RI RI RR 1; Ribonucleoside-diphosphate reductase large subunit; Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunit; ribonucleotide reductase M1 polypeptide; ribonucleotide reductase, R1 subunit; RIR 1
Gene Aliases: R1; RIR1; RnrM1; RR1; RRM1
UniProt ID: (Human) P23921, (Mouse) P07742
Entrez Gene ID: (Human) 6240, (Mouse) 20133
mitotic cell cycle
pyrimidine nucleobase metabolic process
DNA replication
male gonad development
deoxyribonucleotide biosynthetic process
response to ionizing radiation
nucleobase-containing small molecule interconversion
cell proliferation in forebrain
protein heterotetramerization
oxidation-reduction process
retina development in camera-type eye
metabolic process
protein oligomerization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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