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RRM2 Polyclonal Antibody

RRM2 Antibody in Immunocytochemistry (ICC/IF)

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RRM2 Antibody (11661-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Methanol) fixed HepG2 cells using RRM2 antibody (Product # 11661-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

RRM2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

RRM2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11661-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:400

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RRM2 Fusion Protein Ag2203 (1-389 aa encoded by BC030154)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLSLRVPLA PITDPQQLQL SPLKGLSLVD KENTPPALSG TRVLASKTAR RIFQEPTEPK TKAAAPGVED EPLLRENPRR FVIFPIEYHD IWQMYKKAEA SFWTAEEVDL SKDIQHWESL KPEERYFISH VLAFFAASDG IVNENLVERF SQEVQITEAR CFYGFQIAME NIHSEMYSLL IDTYIKDPKE REFLFNAIET MPCVKKKADW ALRWIGDKEA TYGERVVAFA AVEGIFFSGS FASIFWLKKR GLMPGLTFSN ELISRDEGLH CDFACLMFKH LVHKPSEERV REIIINAVRI EQEFLTEALP VKLIGMNCTL MKQYIEFVAD RLMLELGFSK VFRVENPFDF MENISLEGKT NFFEKRVGEY QRMGVMSSPT ENSFTLDADF (1-389 aa encoded by BC030154)

Target Information

RRM2 is one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the protein (M2) is regulated in a cell-cycle dependent fashion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

miR-342-5p downstream to Notch enhances arterialization of endothelial cells in response to shear stress by repressing MYC.

Molecular therapy. Nucleic acids

Zhang X,Sun J,Zhang P,Wen T,Wang R,Liang L,Yang Z,Li J,Zhang J,Che B,Feng X,Liu X,Han H,Yan X

Tue Jun 13 00:00:00 UTC 2023

C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.

Communications biology

Tan J,Wang W,Liu X,Xu J,Che Y,Liu Y,Hu J,Hu L,Li J,Zhou Q

Mon Jun 05 00:00:00 UTC 2023

Novel Prognostic Signatures of Hepatocellular Carcinoma Based on Metabolic Pathway Phenotypes.

Frontiers in oncology

Ye T,Lin L,Cao L,Huang W,Wei S,Shan Y,Zhang Z

Sat Jul 16 00:00:00 UTC 2022

lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients.

Oxidative medicine and cellular longevity

Liang G,Zeng M,Gao M,Xing W,Jin X,Wang Q,Deng L,Ou H,He Z

Tue Mar 08 00:00:00 UTC 2022

Breaking the Iron Homeostasis: A "Trojan Horse" Self-Assembled Nanodrug Sensitizes Homologous Recombination Proficient Ovarian Cancer Cells to PARP Inhibition.

ACS nano

Li Y,Cen Y,Fang Y,Tang S,Li S,Ren Y,Zhang H,Lu W,Xu J

Tue Aug 23 00:00:00 UTC 2022

Integrated multi-omics approach revealed cellular senescence landscape.

Nucleic acids research

Song Q,Hou Y,Zhang Y,Liu J,Wang Y,Fu J,Zhang C,Cao M,Cui Y,Zhang X,Wang X,Zhang J,Liu C,Zhang Y,Wang P

Fri Oct 28 00:00:00 UTC 2022

Integrated multi-omics approach revealed cellular senescence landscape.

Nucleic acids research

Song Q,Hou Y,Zhang Y,Liu J,Wang Y,Fu J,Zhang C,Cao M,Cui Y,Zhang X,Wang X,Zhang J,Liu C,Zhang Y,Wang P

Fri Oct 28 00:00:00 UTC 2022

A novel four-gene of iron metabolism-related and methylated for prognosis prediction of hepatocellular carcinoma.

Bioengineered

Shen H,Wu H,Sun F,Qi J,Zhu Q

Wed Dec 01 00:00:00 UTC 2021

A Novel Ferroptosis-Based Molecular Signature Associated with Biochemical Recurrence-Free Survival and Tumor Immune Microenvironment of Prostate Cancer.

Frontiers in cell and developmental biology

Ke ZB,You Q,Sun JB,Zhu JM,Li XD,Chen DN,Su L,Zheng QS,Wei Y,Xue XY,Xu N

Tue Jan 25 00:00:00 UTC 2022

The High Expression of RRM2 Can Predict the Malignant Transformation of Endometriosis.

Advances in therapy

Yang B,Wang T,Li N,Zhang W,Hu Y

Fri Oct 01 00:00:00 UTC 2021

Identification of osalmid metabolic profile and active metabolites with anti-tumor activity in human hepatocellular carcinoma cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wu Z,Zhan Y,Wang L,Tong J,Zhang L,Lin M,Jin X,Jiang L,Lou Y,Qiu Y

Thu Oct 01 00:00:00 UTC 2020

Potential tumor‑suppressive role of microRNA‑99a‑3p in sunitinib‑resistant renal cell carcinoma cells through the regulation of RRM2.

International journal of oncology

Osako Y,Yoshino H,Sakaguchi T,Sugita S,Yonemori M,Nakagawa M,Enokida H

Wed May 01 00:00:00 UTC 2019

Inhibition of HIV early replication by the p53 and its downstream gene p21.

Virology journal

Shi B,Sharifi HJ,DiGrigoli S,Kinnetz M,Mellon K,Hu W,de Noronha CMC

Tue Mar 27 00:00:00 UTC 2018

Inhibition of HIV early replication by the p53 and its downstream gene p21.

Virology journal

Shi B,Sharifi HJ,DiGrigoli S,Kinnetz M,Mellon K,Hu W,de Noronha CMC

Tue Mar 27 00:00:00 UTC 2018

Long-term HIV-1 infection induces an antiviral state in primary macrophages.

Antiviral research

Pujantell M,Badia R,Ramirez C,Puig T,Clotet B,Ballana E,Esté JA,Riveira-Muñoz E

Thu Sep 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: Ribonucleoside-diphosphate reductase subunit M2; ribonucleotide reductase M2 polypeptide; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit; RRR2M

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Gene Aliases: R2; RR2; RR2M; RRM2

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UniProt ID: (Human) P31350

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Entrez Gene ID: (Human) 6241

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Function(s)

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor protein binding metal ion binding

Process(es)

G1/S transition of mitotic cell cycle regulation of transcription involved in G1/S transition of mitotic cell cycle DNA replication deoxyribonucleoside diphosphate metabolic process deoxyribonucleotide biosynthetic process nucleobase-containing small molecule interconversion protein heterotetramerization oxidation-reduction process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RRM2 Polyclonal Antibody

RRM2 Antibody (11661-1-AP) in ICC/IF

Product Details

11661-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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