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Immunogen sequence: PDDSAIFSAA KDCSIIKWSV ESGRKLHVIP RAKKGAEGKP PGHSSHVLCM AISSDGKYLA SGDRSKLILI WEAQSCQHLY TFTGHRDAVS GLAFRRGTHQ LYSTSHDRSV KVWNVAENSY VETLFGHQDA VAALDALSRE CCVTAGGRDG TVRVWKIPEE SQLVFYGHQG SIDCIHLINE EHMVSGADDG SVALWGLSKK RPLALQREAH GLRGEPGLEQ PFWISSVAAL LNTDLVATGS HSSCVRLWQC GEGFRQLDLL CDIPLVGFIN SLKFSSSGDF LVAGVGQEHR LGRWWRIKEA RNSVCIIPLR RVPVPPAAGS
The Ku autoantigen is a heterodimer of 70kDa (p70) and approximately 80kDa (p80) proteins. The p70/p80 dimer is important for function of a 460kDa DNA-dependent protein kinase that phosphorylates certain transcription factors, including Sp1, Oct-1, p53, and SV40 large T antigen in vitro. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: RNA, U3 small nucleolar interacting protein 2; RRP9 homolog; U3 small nucleolar ribonucleoprotein-associated 55 kDa protein; U3 small nucleolar RNA-interacting protein 2; U3 snoRNP-associated 55 kDa protein; U3 snoRNP-associated 55-kDa protein; U3 snoRNP-associated protein
Gene Aliases: 55kDa; D19435; D9Wsu10e; Rnu3ip2; Rrp9; U3-55k
UniProt ID: (Mouse) Q91WM3
Entrez Gene ID: (Mouse) 27966
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