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Abnova
RSAD2 Polyclonal Antibody, MaxPab™
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Product Details
H00091543-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RSAD2 (NP_542388.2, 1 a.a. approximately 361 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MWVLTPAAFA GKLLSVFRQP LSSLWRSLVP LFCWLRATFW LLATKRRKQQ LVLRGPDETK EEEEDPPLPT TPTSVNYHFT RQCNYKCGFC FHTAKTSFVL PLEEAKRGLL LLKEAGMEKI NFSGGEPFLQ DRGEYLGKLV RFCKVELRLP SVSIVSNGSL IRERWFQNYG EYLDILAISC DSFDEEVNVL IGRGQGKKNH VENLQKLRRW CRDYRVAFKI NSVINRFNVE EDMTEQIKAL NPVRWKVFQC LLIEGENCGE DALREAERFV IGDEEFERFL ERHKEVSCLV PESNQKMKDS YLILDEYMRF LNCRKGRKDP SKSILDVGVE EAIKFSGFDE KMFLKRGGKY IWSKADLKLD W
Target Information
Viperin is a 43kDa protein which is one of several hundred interferon inducible viral proteins. Elevated expression of viperin is induced by LPS and poly I:C through TLR dependent signaling pathways. Sendai virus mediated viperin expression is induced independently of TLR signaling pathways through RLRs - RIG-I and MAVs (Severa, 2006). Viperin has been shown to play an important role in interferon mediated anti-viral activity in a Hepatitis C virus model system (Helbig, 2011). Viperin is induced in lymphoid cells and dendritic cells (DCs) and highly induced in neutrophils and macrophages during acute LCMV infection in mice (Hinson, ). Viperin functions as a mediator of viral resistance and as a marker for interferon responsiveness making its detection and mechanism of action through specific antibody probes valuable for further studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cytomegalovirus-induced gene 5 protein; Radical S-adenosyl methionine domain-containing protein 2; RSAD2; S-adenosylmethionine-dependent nucleotide dehydratase RSAD2; SAND; Viperin; Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
Gene Aliases: 2510004L01Rik; cig33; CIG5; RSAD2; vig1
UniProt ID: (Human) Q8WXG1
Entrez Gene ID: (Human) 91543
response to virus
positive regulation of toll-like receptor 7 signaling pathway
positive regulation of toll-like receptor 9 signaling pathway
CD4-positive, alpha-beta T cell activation
CD4-positive, alpha-beta T cell differentiation
negative regulation of viral genome replication
negative regulation of protein secretion
defense response to virus
type I interferon signaling pathway
positive regulation of T-helper 2 cell cytokine production
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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