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Invitrogen
RSK1/RSK2/RSK3 Polyclonal Antibody
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RSK1/RSK2/RSK3 Antibody (PA5-17680) in WB
Western Blot was performed using Anti-RSK1/RSK2/RSK3 Polyclonal Antibody (Product # PA5-17680) and a 80 kDa band corresponding to Ribosomal protein S6 kinase alpha-1 was observed. Whole cell extracts (30 µg lysate) of HEK-293 (Lane 1), HeLa (Lane 2), K-562 (Lane 3), A-431 (Lane 4), HEL 92.1.7 (Lane 5) and BJ (Lane 6) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001... View More
Product Details
PA5-17680
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues surrounding Asp659 of human p90RSK
Conjugate
Form
Liquid
Concentration
268 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10979767
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 90 kDa ribosomal protein S6 kinase 1; 90 kDa ribosomal protein S6 kinase 2; 90 kDa ribosomal protein S6 kinase 3; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1; MAP kinase-activated protein kinase 1a; MAP kinase-activated protein kinase 1b; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1; MAPK-activated protein kinase 1a; MAPK-activated protein kinase 1b; MAPK-activated protein kinase 1c; MAPKAP kinase 1; MAPKAP kinase 1a; MAPKAP kinase 1b; MAPKAP kinase 1C; MAPKAPK-1; MAPKAPK-1a; MAPKAPK-1b; MAPKAPK-1c; MAPKAPK1A; mitogen-activated protein kinase-activated protein kinase 1C; p90 rsk; p90-RSK; p90-RSK 1; p90-RSK 2; p90-RSK 3; p90RSK1; p90RSK2; p90S6K; pp90RSK1; pp90RSK2; pp90RSK3; Protein-tyrosine kinase Mpk-9; ribosomal protein S6 kinase 2; Ribosomal protein S6 kinase 2 alpha; ribosomal protein S6 kinase alpha 1; ribosomal protein S6 kinase alpha 2; Ribosomal protein S6 kinase alpha-1; Ribosomal protein S6 kinase alpha-2; Ribosomal protein S6 kinase alpha-3; Ribosomal protein S6 kinase II alpha; ribosomal protein S6 kinase polypeptide 1; ribosomal protein S6 kinase, 90kD, polypeptide 1; Ribosomal protein S6 kinase, 90kD, 1; ribosomal protein S6 kinase, 90kD, polypeptide 2; ribosomal protein S6 kinase, 90kDa, polypeptide 1; ribosomal protein S6 kinase, 90kDa, polypeptide 2; ribosomal protein S6 kinase, 90kDa, polypeptide 3; Ribosomal S6 kinase 1; Ribosomal S6 kinase 2; Ribosomal S6 kinase 3; RP11-393H10.3; RSK-1; RSK-2; RSK-3; S6 protein kinase (Rsk-1); S6K-alpha 1; S6K-alpha 2; S6K-alpha-1; S6K-alpha-2; S6K-alpha-3; S6KII-alpha
Gene Aliases: 90kDa; C130006E23; CLS; D17Wsu134e; HU-1; HU-2; HU-3; ISPK-1; ISPK1; Mapkapk-1a; MAPKAPK-1b; MAPKAPK1A; MAPKAPK1B; MAPKAPK1C; MPK-9; MRX19; p90-Rsk1; p90-RSK2; p90-RSK3; p90Rsk; p90Rsk1; p90RSK2; p90RSK3; p90S6K; pp90rsk; pp90RSK2; pp90RSK3; RGD1563860; RPS6KA; Rps6ka-rs1; RPS6KA1; RPS6KA2; RPS6KA3; RSK; Rsk-1; RSK1; RSK2; RSK3; S6K-alpha; S6K-alpha-1; S6K-alpha2; S6K-alpha3
UniProt ID: (Chicken) P18652, (Human) Q15418, (Human) Q15349, (Human) P51812, (Rat) Q63531, (Mouse) P18653, (Mouse) Q9WUT3, (Mouse) P18654
Entrez Gene ID: (Chicken) 386579, (Human) 6195, (Human) 6196, (Human) 6197, (Rat) 81771, (Mouse) 20111, (Mouse) 20112, (Rat) 117269, (Mouse) 110651, (Rat) 501560
magnesium ion binding
protein serine/threonine kinase activity
ATP binding
protein serine/threonine/tyrosine kinase activity
protein binding
kinase activity
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
ribosomal protein S6 kinase activity
protein kinase activity
protein kinase binding
transcription factor binding
nucleotide binding
transferase activity
transferase activity, transferring phosphorus-containing groups
molecular_function
toll-like receptor signaling pathway
regulation of translation
protein phosphorylation
cell cycle
phosphorylation
response to lipopolysaccharide
intracellular signal transduction
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of transcription from RNA polymerase II promoter
skeletal system development
apoptotic process
signal transduction
central nervous system development
positive regulation of cell growth
negative regulation of apoptotic process
regulation of translation in response to stress
regulation of DNA-templated transcription in response to stress
positive regulation of cell differentiation
oocyte maturation
brain renin-angiotensin system
heart development
negative regulation of cell proliferation
positive regulation of gene expression
cardiac muscle cell apoptotic process
peptidyl-serine phosphorylation
positive regulation of apoptotic process
negative regulation of cell cycle
negative regulation of meiotic nuclear division
heart contraction
regulation of protein processing
cellular response to carbohydrate stimulus
biological_process
hepatocyte proliferation
positive regulation of hepatic stellate cell activation
positive regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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