Proteintech

RSPO1 Polyclonal Antibody

FIGURE: 1 / 1

RSPO1 Antibody (25348-1-AP) in WB

Human plasma tissue were subjected to SDS PAGE followed by western blot with 25348-1-AP ( RSPO1 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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Product Details

25348-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 5 publications 5 publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RSPO1 Fusion Protein Ag21858 (1-263 aa encoded by BC114966)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MRLGLCVVA LVLSWTHLTI SSRGIKGKRQ RRISAEGSQA CAKGCELCSE VNGCLKCSPK LFILLERNDI RQVGVCLPSC PPGYFDARNP DMNKCIKCKI EHCEACFSHN FCTKCKEGLY LHKGRCYPAC PEGSSAANGT MECSSPAQCE MSEWSPWGPC SKKQQLCGFR RGSEERTRRV LHAPVGDHAA CSDTKETRRC TVRRVPCPEG QKRRKGGQGR RENANRNLAR KESKEAGAGS RRRKGQQQQQ QQGTVGPLTS AGPA (1-263 aa encoded by BC114966)

Target Information

This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Functional analysis of the 1p34.3 risk locus implicates GNL2 in high-grade serous ovarian cancer.

American journal of human genetics

Nakamura K,Reid BM,Chen A,Chen Z,Goode EL,Permuth JB,Teer JK,Tyrer J,Yu X,Kanetsky PA,Pharoah PD,Gayther SA,Sellers TA,Lawrenson K,Karreth FA

Thu Jan 06 00:00:00 UTC 2022

Transit-amplifying cells control R-spondins in the mouse crypt to modulate intestinal stem cell proliferation.

The Journal of experimental medicine

Chaves-Pérez A,Santos-de-Frutos K,de la Rosa S,Herranz-Montoya I,Perna C,Djouder N

Mon Nov 07 00:00:00 UTC 2022

Transit-amplifying cells control R-spondins in the mouse crypt to modulate intestinal stem cell proliferation.

The Journal of experimental medicine

Chaves-Pérez A,Santos-de-Frutos K,de la Rosa S,Herranz-Montoya I,Perna C,Djouder N

Mon Nov 07 00:00:00 UTC 2022

Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis.

Cardiovascular research

Singla B,Lin HP,Chen A,Ahn W,Ghoshal P,Cherian-Shaw M,White J,Stansfield BK,Csányi G

Tue May 25 00:00:00 UTC 2021

A Novel Identified Long Non-coding RNA, lncRNA MEF2C-AS1, Inhibits Cervical Cancer via Regulation of miR-592/RSPO1.

Frontiers in molecular biosciences

Wang X,Zhang C,Gong M,Jiang C

Sat Jun 26 00:00:00 UTC 2021

N-Glycosylation of Human R-Spondin 1 Is Required for Efficient Secretion and Stability but Not for Its Heparin Binding Ability.

International journal of molecular sciences

Chang CF,Hsu LS,Weng CY,Chen CK,Wang SY,Chou YH,Liu YY,Yuan ZX,Huang WY,Lin H,Chen YH,Tsai JN

Tue Jun 14 00:00:00 UTC 2016

N-Glycosylation of Human R-Spondin 1 Is Required for Efficient Secretion and Stability but Not for Its Heparin Binding Ability.

International journal of molecular sciences

Chang CF,Hsu LS,Weng CY,Chen CK,Wang SY,Chou YH,Liu YY,Yuan ZX,Huang WY,Lin H,Chen YH,Tsai JN

Tue Jun 14 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: FLJ40906; hRspo1; R-spondin homolog; R-spondin-1; Roof plate-specific spondin-1; RP11-566C13.1

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Gene Aliases: CRISTIN3; RSPO; RSPO1

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UniProt ID: (Human) Q2MKA7

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Entrez Gene ID: (Human) 284654

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Function(s)

G-protein coupled receptor binding receptor binding protein binding heparin binding

Process(es)

positive regulation of protein phosphorylation regulation of receptor internalization Wnt signaling pathway positive regulation of Wnt signaling pathway positive regulation of canonical Wnt signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RSPO1 Polyclonal Antibody

RSPO1 Antibody (25348-1-AP) in WB

Product Details

25348-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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