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Invitrogen
RSPO1 Polyclonal Antibody
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FIGURE: 1 / 8
RSPO1 Antibody (PA5-20749) in ICC/IF
Immunofluorescent analysis of 4% paraformaldehyde-fixed human spleen labeling RSPO1 with RSPO1 Polyclonal Antibody (Product # PA5-20749) at 5 µg/mL, followed by goat anti-rabbit IgG secondary antibody at 1:500 dilution (green) with Phylloidin staining (red) and DAPI staining (blue).
Product Details
PA5-20749
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 16 amino acid peptide from near the amino terminus of human RSPO1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11152354
Product Specific Information
A suggested positive control is rat spleen tissue lysate.
PA5-20749 can be used with blocking peptide PEP-0863.
Target Information
This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cristin-3; Cysteine-rich and single thrombospondin domain-containing protein 3; FLJ40906; hRspo1; mCristin-3; R-spondin homolog; R-spondin-1; Roof plate-specific spondin-1; RP11-566C13.1; thrombospondin type 1 domain containing gene Rspondin
Gene Aliases: CRISTIN3; R-spondin; RSPO; RSPO1; Rspondin
UniProt ID: (Human) Q2MKA7, (Mouse) Q3V1S3
Entrez Gene ID: (Human) 284654, (Mouse) 192199
positive regulation of protein phosphorylation
regulation of receptor internalization
Wnt signaling pathway
positive regulation of Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
male meiosis
regulation of gene expression
response to stimulus
canonical Wnt signaling pathway
positive regulation of non-canonical Wnt signaling pathway
regulation of male germ cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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